Job Opportunities at SBRC

  • Postdoctoral Position in Microfluidics to Study Biological Molecular Machines

    Description

    Postdoctoral position is available in laboratory of Rouslan Efremov at VIB-VUB Center for Structural Biology in Brussels (www.cryo-em.be). Our laboratory studies structure of proteins using single particle cryogenic electron microscopy with particular interest in the mechanisms of biological molecular machines. Our goal is to observe molecular machines in action at atomic resolution using cryogenic electron microscopy. The project aims at developing microfluidics-based approaches for rapid reaction initiation and quenching compatible with cryogenic electron microscopy to study fast dynamics in molecular machines.

    Profile

    ​The ideal candidates will have PhD in physics/engineering/biophysics or related discipline, have strong interest in structural biology, molecular machines in particular, and excellent experimentalists/engineering skills.

    Prior experience in microfluidics and one or more of the following: electronics, microfluidic actuators, microfabrication, fast mixing, optics, programming is essential. Previous experience with proteins, protein purification, structural biology or electron microscopy will be of an advantage.

    For further enquiries please contact Rouslan Efremov or visit the VIB job posting.

    We offer

    • Three-year postdoctoral position.
    • The candidate will have an opportunity to learn electron microscopy and methods for determining protein structures using single particle cryo-EM.

     

  • Postdoctoral Position in Microfluidics: Miniaturization of Protein Purification

    Description

    We are looking for a motivated postdoc with experience in microfluidics to join the laboratory of Rouslan Efremov at VIB-VUB Center for Structural Biology in Brussels (www.cryo-em.be). Our laboratory studies structure of proteins using single particle cryogenic electron microscopy with particular interest in the mechanisms of biological molecular machines and has experience in production, purification and structure determination of proteins as well as in engineering, programming, designing and building instruments. The focus of the project will be on miniaturizing sample preparation approaches, which will open opportunities for visualizing biological macromolecular complexes at atomic resolution using cryogenic electron microscopy.

    For further enquiries please contact Rouslan Efremov or see the VIB job posting.

    Profile

    ​The ideal candidate will have PhD in physics/biophysics/engineering or related discipline. Will be an excellent experimentalist/engineer and will be experienced in designing, fabricating and using microfluidic integrated devices, preferentially for biological applications and have a strong interest in structural biology.

    Previous experience with proteins, protein purification, structural biology or electron microscopy will be of an advantage.

    We offer

    • Three-year postdoctoral position.
    • The candidate will have an opportunity to learn electron microscopy and methods for determining protein structures using single particle cryo-EM.

     

  • Electron Microscopist to Manage Biological Cryo-EM Center

    Description

    VIB-VUB Center for Structural Biology is seeking an electron microscopist to manage our Biological High-Resolution Cryo-EM Facility that will serve to a large community of users including internal, Belgian and European users. The cryo-EM facility manager will be responsible for ensuring efficient operation of the center: assisting cryo-EM users with sample preparation for single particle and tomography experiments, data collection, user training and maintaining microscopes in the best conditions.

    VIB-VUB Center for Structural Biology is located in Brussels and houses research groups with strong expertize in protein biochemistry, X-ray crystallography, NMR, biophysics, nanobody technology and electron microscopy. Our department tightly collaborates with other VIB departments on cutting edge biological research problems ranging from human diseases to plant biotechnology. The department is establishing a state-of-the-art cryo-EM facility for high-resolution single particle cryo-EM and cryo-tomography. The facility will include a new generation JEOL cryoARM300 300 kV electron microscope equipped with direct electron detector and two JEOL JEM1400 120 kV electron microscopes for sample screening and imaging of negatively stained samples.

    For further enquiries please contact Rouslan Efremov or visit the VIB job posting.

    Profile

    • The candidate should have an extensive experience in transmission electron microscopy.
    • Preferred candidate will have experience in biological cryo-EM and will be familiar with structural biology methods.