Proteins are some of the most fascinating and complex macromolecules in living systems that play extraordinarily diverse roles in sustaining life. These roles are mediated through the interactions that proteins make both with other proteins and with different molecular constituents of the cell. The continuing focus of my research is on investigating the principles (structural, energetic and dynamic) that govern protein interactions. To that end I employ molecular simulation and modeling techniques to study protein-protein protein-DNA, and protein-ligand interactions at the atomic scale. I am furthermore keen on analyzing the properties of known protein structures and sequences in order to gain insight into how evolution has shaped the functional specificity of proteins. In parallel to these molecular level investigations I am actively engaged in developing quantitative and integrative computational approaches for analyzing physical and functional interactions between proteins, protein complexes and biochemical pathways at the cellular level. My research activities closely combine the development of analysis methods and software tools, with their application to important biological problems with relevance to human health.
- Protein Phase Separation: A New Phase in Cell Biology.
- Redox-regulated methionine oxidation of Arabidopsis thaliana glutathione transferase Phi9 induces H-site flexibility.
- Crystal structure of human Mediator subunit MED23.
- Phasing in on the cell cycle.
- Protein Promiscuity in HO Signaling.
- Crystal Structure of a ligand-bound LacY-Nanobody Complex.
- Molecular Motions and Interactions in Aqueous Solutions of Thymosin-β , Stabilin C-Terminal Domain (CTD) and Their 1:1 Complex Studied by H NMR Spectroscopy.
- Pathways crossing mammalian and plant sulfenomic landscapes.