Publications

Found 49 results
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2019
Talavera, A., H. Tamman, A. Ainelo, A. Konijnenberg, S. Hadži, F. Sobott, A. Garcia-Pino, R. Hõrak, and R. Loris, "A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT.", Nat Commun, vol. 10, issue 1, pp. 972, 2019 02 27.
2018
Talavera, A., J. Hendrix, W. Versées, D. Jurenas, K. Van Nerom, N. Vandenberk, R. Kumar Singh, A. Konijnenberg, S. De Gieter, D. Castro-Roa, et al., "Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.", Sci Adv, vol. 4, issue 3, pp. eaap9714, 2018 03.
2017
Talavera, A., H. Tamman, A. Ainelo, S. Hadǽi, A. Garcia-Pino, R. Hõrak, A. Konijnenberg, and R. Loris, "Production, biophysical characterization and crystallization of Pseudomonas putida GraA and its complexes with GraT and the graTA operator.", Acta Crystallogr F Struct Biol Commun, vol. 73, issue Pt 8, pp. 455-462, 2017 Aug 01.
Hadži, S., A. Garcia-Pino, S. Haesaerts, D. Jurenas, K. Gerdes, J. Lah, and R. Loris, "Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism.", Nucleic Acids Res, vol. 45, issue 8, pp. 4972-4983, 2017 May 05.
2016
Egea-Jimenez, A. Luis, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. Maria Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau, and P. Zimmermann, "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.", Nat Commun, vol. 7, pp. 12101, 2016 07 08.
Garcia-Pino, A., S. De Gieter, A. Talavera, H. De Greve, R. G. Efremov, and R. Loris, "An intrinsically disordered entropic switch determines allostery in Phd-Doc regulation.", Nat Chem Biol, vol. 12, issue 7, pp. 490-6, 2016 07.
Zorzini, V., A. Mernik, J. Lah, Y. G. J. Sterckx, N. De Jonge, A. Garcia-Pino, H. De Greve, W. Versées, and R. Loris, "Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.", J Biol Chem, vol. 291, issue 21, pp. 10950-60, 2016 May 20.
Sterckx, Y. G. - J., T. Jové, A. V. Shkumatov, A. Garcia-Pino, L. Geerts, M. De Kerpel, J. Lah, H. De Greve, L. Van Melderen, and R. Loris, "A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex.", J Mol Biol, vol. 428, issue 8, pp. 1589-603, 2016 Apr 24.
2015
Hadži, S., A. Garcia-Pino, K. Gerdes, J. Lah, and R. Loris, "Crystallization of two operator complexes from the Vibrio cholerae HigBA2 toxin-antitoxin module.", Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 2, pp. 226-33, 2015 Feb.
Sterckx, Y. G. - J., S. De Gieter, V. Zorzini, S. Hadži, S. Haesaerts, R. Loris, and A. Garcia-Pino, "An efficient method for the purification of proteins from four distinct toxin-antitoxin modules.", Protein Expr Purif, vol. 108, pp. 30-40, 2015 Apr.
Huculeci, R., A. Garcia-Pino, L. Buts, T. Lenaerts, and N. van Nuland, "Structural insights into the intertwined dimer of fyn SH2.", Protein Sci, vol. 24, issue 12, pp. 1964-78, 2015 Dec.
2014
Loris, R., and A. Garcia-Pino, "Disorder- and dynamics-based regulatory mechanisms in toxin-antitoxin modules.", Chem Rev, vol. 114, issue 13, pp. 6933-47, 2014 Jul 09.
De Gieter, S., A. Konijnenberg, A. Talavera, A. Butterer, S. Haesaerts, H. De Greve, F. Sobott, R. Loris, and A. Garcia-Pino, "The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.", J Biol Chem, vol. 289, issue 49, pp. 34013-23, 2014 Dec 05.
Garcia-Pino, A., N. Zenkin, and R. Loris, "The many faces of Fic: structural and functional aspects of Fic enzymes.", Trends Biochem Sci, vol. 39, issue 3, pp. 121-9, 2014 Mar.
Bethuyne, J., S. De Gieter, O. Zwaenepoel, A. Garcia-Pino, K. Durinck, A. Verhelle, G. Hassanzadeh-Ghassabeh, F. Speleman, R. Loris, and J. Gettemans, "A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.", Nucleic Acids Res, vol. 42, issue 20, pp. 12928-38, 2014 Nov 10.
Fislage, M., E. Brosens, E. Deyaert, A. Spilotros, E. Pardon, R. Loris, J. Steyaert, A. Garcia-Pino, and W. Versées, "SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization.", Nucleic Acids Res, vol. 42, issue 9, pp. 5978-92, 2014 May.
Sterckx, Y. G. J., A. Volkov, W. F. Vranken, J. Kragelj, M. Ringkjøbi Jensen, L. Buts, A. Garcia-Pino, T. Jové, L. Van Melderen, M. Blackledge, et al., "Small-angle X-ray scattering- and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2.", Structure, vol. 22, issue 6, pp. 854-65, 2014 Jun 10.
Zorzini, V., L. Buts, M. Sleutel, A. Garcia-Pino, A. Talavera, S. Haesaerts, H. De Greve, A. Cheung, N. A. J. van Nuland, and R. Loris, "Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics.", Nucleic Acids Res, vol. 42, issue 10, pp. 6709-25, 2014 Jun.
M Ceregido, A., M. Spínola Amilibia, L. Buts, J. Rivera-Torres, A. Garcia-Pino, J. Bravo, and N. A. J. van Nuland, "The structure of TAX1BP1 UBZ1+2 provides insight into target specificity and adaptability.", J Mol Biol, vol. 426, issue 3, pp. 674-90, 2014 Feb 06.
Vanwetswinkel, S., A. Volkov, Y. G. J. Sterckx, A. Garcia-Pino, L. Buts, W. F. Vranken, J. Bouckaert, R. Roy, L. Wyns, and N. A. J. van Nuland, "Study of the structural and dynamic effects in the FimH adhesin upon α-d-heptyl mannose binding.", J Med Chem, vol. 57, issue 4, pp. 1416-27, 2014 Feb 27.
2013
De Gieter, S., R. Loris, N. A. J. van Nuland, and A. Garcia-Pino, "(1)H, (13)C, and (15)N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state.", Biomol NMR Assign, 2013 Feb 19.
Hadži, S., A. Garcia-Pino, S. Martinez-Rodriguez, K. Verschueren, M. Christensen-Dalsgaard, K. Gerdes, J. Lah, and R. Loris, "Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 9, pp. 1052-9, 2013 Sep.
Castro-Roa, D., A. Garcia-Pino, S. De Gieter, N. A. J. van Nuland, R. Loris, and N. Zenkin, "The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu.", Nat Chem Biol, vol. 9, issue 12, pp. 811-7, 2013 Dec.
Ceregido Pérez, M de los Á., A. Garcia-Pino, J. L. Ortega-Roldan, S. Casares, O. López Mayorga, J. Bravo, N. A. J. van Nuland, and A. I. Azuaga, "Multimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*.", FEBS J, vol. 280, issue 14, pp. 3399-415, 2013 Jul.
Ghequire, M. G. K., A. Garcia-Pino, E. K. M. Lebbe, S. Spaepen, R. Loris, and R. De Mot, "Structural determinants for activity and specificity of the bacterial toxin LlpA.", PLoS Pathog, vol. 9, issue 2, pp. e1003199, 2013 Feb.

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