Publications

Found 62 results
Filters: Author is Pardon, Els  [Clear All Filters]
2017
Schacherl, M., Gompert M., Pardon E., Lamkemeyer T., Steyaert J., and Baumann U., "Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.", Biochim Biophys Acta, vol. 1859, issue 10, pp. 1859-1871, 2017 10.
Schenck, S., Kunz L., Sahlender D., Pardon E., Geertsma E. R., Savtchouk I., Suzuki T., Neldner Y., Štefanić S., Steyaert J., et al., "Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.", Biochemistry, vol. 56, issue 30, pp. 3962-3971, 2017 Aug 01.
Barros-Álvarez, X., Kerchner K. M., Koh C. Yeow, Turley S., Pardon E., Steyaert J., Ranade R. M., J Gillespie R., Zhang Z., Verlinde C. L. M. J., et al., "Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.", Biochimie, vol. 138, pp. 124-136, 2017 Jul.
Martin, C., Moors S. L. C., Danielsen M., Betti C., Fabris C., Pedersen D. Sejer, Pardon E., Peyressatre M., Fehér K., Martins J. C., et al., "Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands.", Chemistry, vol. 23, issue 40, pp. 9632-9640, 2017 Jul 18.
Raimondi, S., Porcari R., P Mangione P., Verona G., Marcoux J., Giorgetti S., Taylor G. W., Ellmerich S., Ballico M., Zanini S., et al., "A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.", Sci Rep, vol. 7, pp. 46711, 2017 Apr 21.
Miller, P. S., Scott S., Masiulis S., De Colibus L., Pardon E., Steyaert J., and A Aricescu R., "Structural basis for GABAA receptor potentiation by neurosteroids.", Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
Perez, C., Köhler M., Janser D., Pardon E., Steyaert J., Zenobi R., and Locher K. P., "Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.", Sci Rep, vol. 7, pp. 46641, 2017 Apr 19.
2016
Devree, B. T., Mahoney J. P., Vélez-Ruiz G. A., Rasmussen S. G. F., Kuszak A. J., Edwald E., Fung J-J., Manglik A., Masureel M., Du Y., et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Staus, D. P., Strachan R. T., Manglik A., Pani B., Kahsai A. W., Kim T. Hun, Wingler L. M., Ahn S., Chatterjee A., Masoudi A., et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Geertsma, E. R., Chang Y-N., Shaik F. R., Neldner Y., Pardon E., Steyaert J., and Dutzler R., "Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 23, issue 5, pp. 462, 2016 May 04.
Jiang, X., Smirnova I., Kasho V., Wu J., Hirata K., Ke M., Pardon E., Steyaert J., Yan N., and H Kaback R., "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 Nov 01.
Wijckmans, E., Nys M., Debaveye S., Brams M., Pardon E., Willegems K., Bertrand D., Steyaert J., Efremov R. G., and Ulens C., "Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues.", PLoS One, vol. 11, issue 3, pp. e0151183, 2016.
Hariharan, P., Andersson M., Jiang X., Pardon E., Steyaert J., H Kaback R., and Guan L., "Thermodynamics of Nanobody Binding to Lactose Permease.", Biochemistry, vol. 55, issue 42, pp. 5917-5926, 2016 Oct 25.
Figueroa, M., Sleutel M., Vandevenne M., Parvizi G., Attout S., Jacquin O., Vandenameele J., Fischer A. W., Damblon C., Goormaghtigh E., et al., "The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.", J Struct Biol, vol. 195, issue 1, pp. 19-30, 2016 Jul.
2015
Newman, J. A., Savitsky P., Allerston C. K., Bizard A. H., Özer Ö., Sarlós K., Liu Y., Pardon E., Steyaert J., Hickson I. D., et al., "Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.", Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
Moonens, K., Van den Broeck I., Okello E., Pardon E., De Kerpel M., Remaut H., and De Greve H., "Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.", Vet Res, vol. 46, pp. 14, 2015 Feb 24.
Rostislavleva, K., Soler N., Ohashi Y., Zhang L., Pardon E., Burke J. E., Masson G. R., Johnson C., Steyaert J., Ktistakis N. T., et al., "Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.", Science, vol. 350, issue 6257, pp. aac7365, 2015 Oct 09.
Geertsma, E. R., Chang Y-N., Shaik F. R., Neldner Y., Pardon E., Steyaert J., and Dutzler R., "Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 22, issue 10, pp. 803-8, 2015 Oct.
Smirnova, I., Kasho V., Jiang X., Pardon E., Steyaert J., and H Kaback R., "Transient conformers of LacY are trapped by nanobodies.", Proc Natl Acad Sci U S A, vol. 112, issue 45, pp. 13839-44, 2015 Nov 10.
2014
Ehrnstorfer, I. A., Geertsma E. R., Pardon E., Steyaert J., and Dutzler R., "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.", Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
Pathare, G. Ramnath, Nagy I., Śledź P., Anderson D. J., Zhou H-J., Pardon E., Steyaert J., Förster F., Bracher A., and Baumeister W., "Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.", Proc Natl Acad Sci U S A, vol. 111, issue 8, pp. 2984-9, 2014 Feb 25.
Pardon, E., Laeremans T., Triest S., Rasmussen S. G. F., Wohlkonig A., Ruf A., Muyldermans S., Hol W. G. J., Kobilka B. K., and Steyaert J., "A general protocol for the generation of Nanobodies for structural biology.", Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
Nunes-Silva, S., Gangnard S., Vidal M., Vuchelen A., Dechavanne S., Chan S., Pardon E., Steyaert J., Ramboarina S., Chêne A., et al., "Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.", Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
Lo, A. W. H., Moonens K., De Kerpel M., Brys L., Pardon E., Remaut H., and De Greve H., "The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.", J Biol Chem, vol. 289, issue 36, pp. 25374-81, 2014 Sep 05.
Moonens, K., De Kerpel M., Coddens A., Cox E., Pardon E., Remaut H., and De Greve H., "Nanobody mediated inhibition of attachment of F18 Fimbriae expressing Escherichia coli.", PLoS One, vol. 9, issue 12, pp. e114691, 2014.

Pages