Publications

Found 70 results
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2018
Köhler, M., Neff C., Perez C., Brunner C., Pardon E., Steyaert J., Schneider G., Locher K. P., and Zenobi R., "Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry.", Anal Chem, vol. 90, issue 8, pp. 5306-5313, 2018 Apr 17.
Chevillard, F., Rimmer H., Betti C., Pardon E., Ballet S., van Hilten N., Steyaert J., Diederich W. E., and Kolb P., "Binding-Site Compatible Fragment Growing Applied to the Design of β-Adrenergic Receptor Ligands.", J Med Chem, vol. 61, issue 3, pp. 1118-1129, 2018 Feb 08.
Kumar, H., Finer-Moore J. S., Jiang X., Smirnova I., Kasho V., Pardon E., Steyaert J., H Kaback R., and Stroud R. M., "Crystal Structure of a ligand-bound LacY-Nanobody Complex.", Proc Natl Acad Sci U S A, vol. 115, issue 35, pp. 8769-8774, 2018 08 28.
Monté, D., Clantin B., Dewitte F., Lens Z., Rucktooa P., Pardon E., Steyaert J., Verger A., and Villeret V., "Crystal structure of human Mediator subunit MED23.", Nat Commun, vol. 9, issue 1, pp. 3389, 2018 Aug 23.
Pardon, E., Betti C., Laeremans T., Chevillard F., Guillemyn K., Kolb P., Ballet S., and Steyaert J., "Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.", Angew Chem Int Ed Engl, vol. 57, issue 19, pp. 5292-5295, 2018 May 04.
Che, T., Majumdar S., Zaidi S. A., Ondachi P., McCorvy J. D., Wang S., Mosier P. D., Uprety R., Vardy E., Krumm B. E., et al., "Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.", Cell, vol. 172, issue 1-2, pp. 55-67.e15, 2018 Jan 11.
Lee, S., Choi J., Mohanty J., Sousa L. P., Tome F., Pardon E., Steyaert J., Lemmon M. A., Lax I., and Schlessinger J., "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
2017
Schacherl, M., Gompert M., Pardon E., Lamkemeyer T., Steyaert J., and Baumann U., "Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.", Biochim Biophys Acta Biomembr, vol. 1859, issue 10, pp. 1859-1871, 2017 Oct.
Schenck, S., Kunz L., Sahlender D., Pardon E., Geertsma E. R., Savtchouk I., Suzuki T., Neldner Y., Štefanić S., Steyaert J., et al., "Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.", Biochemistry, vol. 56, issue 30, pp. 3962-3971, 2017 08 01.
Barros-Álvarez, X., Kerchner K. M., Koh C. Yeow, Turley S., Pardon E., Steyaert J., Ranade R. M., J Gillespie R., Zhang Z., Verlinde C. L. M. J., et al., "Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.", Biochimie, vol. 138, pp. 124-136, 2017 Jul.
Martin, C., Moors S. L. C., Danielsen M., Betti C., Fabris C., Pedersen D. Sejer, Pardon E., Peyressatre M., Fehér K., Martins J. C., et al., "Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β Adrenergic Receptor Ligands.", Chemistry, vol. 23, issue 40, pp. 9632-9640, 2017 Jul 18.
Raimondi, S., Porcari R., P Mangione P., Verona G., Marcoux J., Giorgetti S., Taylor G. W., Ellmerich S., Ballico M., Zanini S., et al., "A specific nanobody prevents amyloidogenesis of D76N β-microglobulin in vitro and modifies its tissue distribution in vivo.", Sci Rep, vol. 7, pp. 46711, 2017 Apr 21.
Miller, P. S., Scott S., Masiulis S., De Colibus L., Pardon E., Steyaert J., and A Aricescu R., "Structural basis for GABA receptor potentiation by neurosteroids.", Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
Perez, C., Köhler M., Janser D., Pardon E., Steyaert J., Zenobi R., and Locher K. P., "Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.", Sci Rep, vol. 7, pp. 46641, 2017 Apr 19.
Schubert, A. F., Gladkova C., Pardon E., Wagstaff J. L., Freund S. M. V., Steyaert J., Maslen S. L., and Komander D., "Structure of PINK1 in complex with its substrate ubiquitin.", Nature, vol. 552, issue 7683, pp. 51-56, 2017 12 07.
2016
Devree, B. T., Mahoney J. P., Vélez-Ruiz G. A., Rasmussen S. G. F., Kuszak A. J., Edwald E., Fung J-J., Manglik A., Masureel M., Du Y., et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Staus, D. P., Strachan R. T., Manglik A., Pani B., Kahsai A. W., Kim T. Hun, Wingler L. M., Ahn S., Chatterjee A., Masoudi A., et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Geertsma, E. R., Chang Y-N., Shaik F. R., Neldner Y., Pardon E., Steyaert J., and Dutzler R., "Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 23, issue 5, pp. 462, 2016 May 04.
Jiang, X., Smirnova I., Kasho V., Wu J., Hirata K., Ke M., Pardon E., Steyaert J., Yan N., and H Kaback R., "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
Wijckmans, E., Nys M., Debaveye S., Brams M., Pardon E., Willegems K., Bertrand D., Steyaert J., Efremov R. G., and Ulens C., "Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues.", PLoS One, vol. 11, issue 3, pp. e0151183, 2016.
Hariharan, P., Andersson M., Jiang X., Pardon E., Steyaert J., H Kaback R., and Guan L., "Thermodynamics of Nanobody Binding to Lactose Permease.", Biochemistry, vol. 55, issue 42, pp. 5917-5926, 2016 Oct 25.
Figueroa, M., Sleutel M., Vandevenne M., Parvizi G., Attout S., Jacquin O., Vandenameele J., Fischer A. W., Damblon C., Goormaghtigh E., et al., "The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.", J Struct Biol, vol. 195, issue 1, pp. 19-30, 2016 Jul.

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