Publications

Found 121 results
Filters: Author is Jan Steyaert  [Clear All Filters]
2016
Devree, B. T., Mahoney J. P., Vélez-Ruiz G. A., Rasmussen S. G. F., Kuszak A. J., Edwald E., Fung J-J., Manglik A., Masureel M., Du Y., et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Staus, D. P., Strachan R. T., Manglik A., Pani B., Kahsai A. W., Kim T. Hun, Wingler L. M., Ahn S., Chatterjee A., Masoudi A., et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Geertsma, E. R., Chang Y-N., Shaik F. R., Neldner Y., Pardon E., Steyaert J., and Dutzler R., "Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 23, issue 5, pp. 462, 2016 May 04.
Burger, D., Stihle M., Sharma A., Di Lello P., Benz J., D'Arcy B., Debulpaep M., Fry D., Huber W., Kremer T., et al., "Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.", J Biol Chem, vol. 291, issue 31, pp. 16292-306, 2016 Jul 29.
Peyrassol, X., Laeremans T., Gouwy M., Lahura V., Debulpaep M., Van Damme J., Steyaert J., Parmentier M., and Langer I., "Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.", J Immunol, vol. 196, issue 6, pp. 2893-901, 2016 Mar 15.
van der Woning, B., De Boeck G., Blanchetot C., Bobkov V., Klarenbeek A., Saunders M., Waelbroeck M., Laeremans T., Steyaert J., Hultberg A., et al., "DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops.", MAbs, vol. 8, issue 6, pp. 1126-35, 2016 Aug-Sep.
Figueroa, M., Sleutel M., Vandevenne M., Parvizi G., Attout S., Jacquin O., Vandenameele J., Fischer A. W., Damblon C., Goormaghtigh E., et al., "The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.", J Struct Biol, vol. 195, issue 1, pp. 19-30, 2016 Jul.
2015
Lan, T-H., Liu Q., Li C., Wu G., Steyaert J., and Lambert N. A., "BRET evidence that β2 adrenergic receptors do not oligomerize in cells.", Sci Rep, vol. 5, pp. 10166, 2015 May 08.
Newman, J. A., Savitsky P., Allerston C. K., Bizard A. H., Özer Ö., Sarlós K., Liu Y., Pardon E., Steyaert J., Hickson I. D., et al., "Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.", Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
Sounier, R., Mas C., Steyaert J., Laeremans T., Manglik A., Huang W., Kobilka B. K., Déméné H., and Granier S., "Propagation of conformational changes during μ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
Huang, W., Manglik A., Venkatakrishnan A. J., Laeremans T., Feinberg E. N., Sanborn A. L., Kato H. E., Livingston K. E., Thorsen T. S., Kling R. C., et al., "Structural insights into µ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 315-21, 2015 Aug 20.
Rostislavleva, K., Soler N., Ohashi Y., Zhang L., Pardon E., Burke J. E., Masson G. R., Johnson C., Steyaert J., Ktistakis N. T., et al., "Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.", Science, vol. 350, issue 6257, pp. aac7365, 2015 Oct 09.
Geertsma, E. R., Chang Y-N., Shaik F. R., Neldner Y., Pardon E., Steyaert J., and Dutzler R., "Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 22, issue 10, pp. 803-8, 2015 Oct.
Smirnova, I., Kasho V., Jiang X., Pardon E., Steyaert J., and H Kaback R., "Transient conformers of LacY are trapped by nanobodies.", Proc Natl Acad Sci U S A, vol. 112, issue 45, pp. 13839-44, 2015 Nov 10.
2014
Somme, J., Van Laer B., Roovers M., Steyaert J., Versées W., and Droogmans L., "Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.", RNA, vol. 20, issue 8, pp. 1257-71, 2014 Aug.
Ehrnstorfer, I. A., Geertsma E. R., Pardon E., Steyaert J., and Dutzler R., "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.", Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
Pathare, G. Ramnath, Nagy I., Śledź P., Anderson D. J., Zhou H-J., Pardon E., Steyaert J., Förster F., Bracher A., and Baumeister W., "Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.", Proc Natl Acad Sci U S A, vol. 111, issue 8, pp. 2984-9, 2014 Feb 25.
Pardon, E., Laeremans T., Triest S., Rasmussen S. G. F., Wohlkonig A., Ruf A., Muyldermans S., Hol W. G. J., Kobilka B. K., and Steyaert J., "A general protocol for the generation of Nanobodies for structural biology.", Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
Oyen, D., Steyaert J., and Barlow J. N., "Inhibition of ligand exchange kinetics via active-site trapping with an antibody fragment.", Biochemistry, vol. 53, issue 12, pp. 1879-81, 2014 Apr 01.
Nunes-Silva, S., Gangnard S., Vidal M., Vuchelen A., Dechavanne S., Chan S., Pardon E., Steyaert J., Ramboarina S., Chêne A., et al., "Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.", Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
Smirnova, I., Kasho V., Jiang X., Pardon E., Steyaert J., and H Kaback R., "Outward-facing conformers of LacY stabilized by nanobodies.", Proc Natl Acad Sci U S A, vol. 111, issue 52, pp. 18548-53, 2014 Dec 30.
Abskharon, R. N. N., Giachin G., Wohlkonig A., Soror S. H., Pardon E., Legname G., and Steyaert J., "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
Triest, S., Wohlkonig A., Pardon E., and Steyaert J., "Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 11, pp. 1504-7, 2014 Nov.
Staus, D. P., Wingler L. M., Strachan R. T., Rasmussen S. G. F., Pardon E., Ahn S., Steyaert J., Kobilka B. K., and Lefkowitz R. J., "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.
Fislage, M., Brosens E., Deyaert E., Spilotros A., Pardon E., Loris R., Steyaert J., Garcia-Pino A., and Versées W., "SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization.", Nucleic Acids Res, vol. 42, issue 9, pp. 5978-92, 2014 May.

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