Publications

Found 127 results
Filters: Author is Jan Steyaert  [Clear All Filters]
2016
Devree, B. T., Mahoney J. P., Vélez-Ruiz G. A., Rasmussen S. G. F., Kuszak A. J., Edwald E., Fung J-J., Manglik A., Masureel M., Du Y., et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Staus, D. P., Strachan R. T., Manglik A., Pani B., Kahsai A. W., Kim T. Hun, Wingler L. M., Ahn S., Chatterjee A., Masoudi A., et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Geertsma, E. R., Chang Y-N., Shaik F. R., Neldner Y., Pardon E., Steyaert J., and Dutzler R., "Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 23, issue 5, pp. 462, 2016 May 04.
Jiang, X., Smirnova I., Kasho V., Wu J., Hirata K., Ke M., Pardon E., Steyaert J., Yan N., and H Kaback R., "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 Nov 01.
Burger, D., Stihle M., Sharma A., Di Lello P., Benz J., D'Arcy B., Debulpaep M., Fry D., Huber W., Kremer T., et al., "Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.", J Biol Chem, vol. 291, issue 31, pp. 16292-306, 2016 Jul 29.
Peyrassol, X., Laeremans T., Gouwy M., Lahura V., Debulpaep M., Van Damme J., Steyaert J., Parmentier M., and Langer I., "Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.", J Immunol, vol. 196, issue 6, pp. 2893-901, 2016 Mar 15.
van der Woning, B., De Boeck G., Blanchetot C., Bobkov V., Klarenbeek A., Saunders M., Waelbroeck M., Laeremans T., Steyaert J., Hultberg A., et al., "DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops.", MAbs, vol. 8, issue 6, pp. 1126-35, 2016 Aug-Sep.
Wijckmans, E., Nys M., Debaveye S., Brams M., Pardon E., Willegems K., Bertrand D., Steyaert J., Efremov R. G., and Ulens C., "Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues.", PLoS One, vol. 11, issue 3, pp. e0151183, 2016.
Ismail, S., Gherardi M-J., Froese A., Zanoun M., Gigoux V., Clerc P., Gaits-Iacovoni F., Steyaert J., Nikolaev V. O., and Fourmy D., "Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.", Biochem Pharmacol, vol. 120, pp. 33-45, 2016 Nov 15.
Claes, K., Vandewalle K., Laukens B., Laeremans T., Vosters O., Langer I., Parmentier M., Steyaert J., and Callewaert N., "Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.", ACS Synth Biol, vol. 5, issue 10, pp. 1070-1075, 2016 Oct 21.
Massa, S., Vikani N., Betti C., Ballet S., Vanderhaegen S., Steyaert J., Descamps B., Vanhove C., Bunschoten A., van Leeuwen F. W. B., et al., "Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.", Contrast Media Mol Imaging, vol. 11, issue 5, pp. 328-339, 2016 Sep.
Hariharan, P., Andersson M., Jiang X., Pardon E., Steyaert J., H Kaback R., and Guan L., "Thermodynamics of Nanobody Binding to Lactose Permease.", Biochemistry, 2016 Oct 12.
Figueroa, M., Sleutel M., Vandevenne M., Parvizi G., Attout S., Jacquin O., Vandenameele J., Fischer A. W., Damblon C., Goormaghtigh E., et al., "The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.", J Struct Biol, vol. 195, issue 1, pp. 19-30, 2016 Jul.
2015
Lan, T-H., Liu Q., Li C., Wu G., Steyaert J., and Lambert N. A., "BRET evidence that β2 adrenergic receptors do not oligomerize in cells.", Sci Rep, vol. 5, pp. 10166, 2015 May 08.
Newman, J. A., Savitsky P., Allerston C. K., Bizard A. H., Özer Ö., Sarlós K., Liu Y., Pardon E., Steyaert J., Hickson I. D., et al., "Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.", Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
Sounier, R., Mas C., Steyaert J., Laeremans T., Manglik A., Huang W., Kobilka B. K., Déméné H., and Granier S., "Propagation of conformational changes during μ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
Huang, W., Manglik A., Venkatakrishnan A. J., Laeremans T., Feinberg E. N., Sanborn A. L., Kato H. E., Livingston K. E., Thorsen T. S., Kling R. C., et al., "Structural insights into µ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 315-21, 2015 Aug 20.
Rostislavleva, K., Soler N., Ohashi Y., Zhang L., Pardon E., Burke J. E., Masson G. R., Johnson C., Steyaert J., Ktistakis N. T., et al., "Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.", Science, vol. 350, issue 6257, pp. aac7365, 2015 Oct 09.
Geertsma, E. R., Chang Y-N., Shaik F. R., Neldner Y., Pardon E., Steyaert J., and Dutzler R., "Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 22, issue 10, pp. 803-8, 2015 Oct.
Smirnova, I., Kasho V., Jiang X., Pardon E., Steyaert J., and H Kaback R., "Transient conformers of LacY are trapped by nanobodies.", Proc Natl Acad Sci U S A, vol. 112, issue 45, pp. 13839-44, 2015 Nov 10.

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