Publications

Found 12 results
Filters: Author is Kobilka, Brian K  [Clear All Filters]
2017
Manglik, A., Kobilka B. K., and Steyaert J., "Nanobodies to Study G Protein-Coupled Receptor Structure and Function.", Annu Rev Pharmacol Toxicol, vol. 57, pp. 19-37, 2017 01 06.
2016
Devree, B. T., Mahoney J. P., Vélez-Ruiz G. A., Rasmussen S. G. F., Kuszak A. J., Edwald E., Fung J-J., Manglik A., Masureel M., Du Y., et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Staus, D. P., Strachan R. T., Manglik A., Pani B., Kahsai A. W., Kim T. Hun, Wingler L. M., Ahn S., Chatterjee A., Masoudi A., et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
2015
Sounier, R., Mas C., Steyaert J., Laeremans T., Manglik A., Huang W., Kobilka B. K., Déméné H., and Granier S., "Propagation of conformational changes during μ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
Huang, W., Manglik A., Venkatakrishnan A. J., Laeremans T., Feinberg E. N., Sanborn A. L., Kato H. E., Livingston K. E., Thorsen T. S., Kling R. C., et al., "Structural insights into µ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 315-21, 2015 Aug 20.
2014
Pardon, E., Laeremans T., Triest S., Rasmussen S. G. F., Wohlkonig A., Ruf A., Muyldermans S., Hol W. G. J., Kobilka B. K., and Steyaert J., "A general protocol for the generation of Nanobodies for structural biology.", Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
Staus, D. P., Wingler L. M., Strachan R. T., Rasmussen S. G. F., Pardon E., Ahn S., Steyaert J., Kobilka B. K., and Lefkowitz R. J., "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.
2013
Kruse, A. C., Ring A. M., Manglik A., Hu J., Hu K., Eitel K., Hübner H., Pardon E., Valant C., Sexton P. M., et al., "Activation and allosteric modulation of a muscarinic acetylcholine receptor.", Nature, vol. 504, issue 7478, pp. 101-6, 2013 Dec 05.
2011
Rasmussen, S. G. F., Devree B. T., Zou Y., Kruse A. C., Chung K. Young, Kobilka T. Sun, Thian F. Sun, Chae P. Seok, Pardon E., Calinski D., et al., "Crystal structure of the β2 adrenergic receptor-Gs protein complex.", Nature, vol. 477, issue 7366, pp. 549-55, 2011 Sep 29.
Steyaert, J., and Kobilka B. K., "Nanobody stabilization of G protein-coupled receptor conformational states.", Curr Opin Struct Biol, vol. 21, issue 4, pp. 567-72, 2011 Aug.
Westfield, G. H., Rasmussen S. G. F., Su M., Dutta S., Devree B. T., Chung K. Young, Calinski D., Velez-Ruiz G., Oleskie A. N., Pardon E., et al., "Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.", Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.
Rasmussen, S. G. F., Choi H-J., Fung J. Jose, Pardon E., Casarosa P., Chae P. Seok, Devree B. T., Rosenbaum D. M., Thian F. Sun, Kobilka T. Sun, et al., "Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.", Nature, vol. 469, issue 7329, pp. 175-80, 2011 Jan 13.