Publications

Found 34 results
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2018
Köhler, M., Neff C., Perez C., Brunner C., Pardon E., Steyaert J., Schneider G., Locher K. P., and Zenobi R., "Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry.", Anal Chem, vol. 90, issue 8, pp. 5306-5313, 2018 Apr 17.
Chevillard, F., Rimmer H., Betti C., Pardon E., Ballet S., van Hilten N., Steyaert J., Diederich W. E., and Kolb P., "Binding-Site Compatible Fragment Growing Applied to the Design of β-Adrenergic Receptor Ligands.", J Med Chem, vol. 61, issue 3, pp. 1118-1129, 2018 Feb 08.
Joncour, A., Desroy N., Housseman C., Bock X., Bienvenu N., Cherel L., Labeguere V., Peixoto C., Annoot D., Lepissier L., et al., "Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.", J Med Chem, vol. 61, issue 9, pp. 4270, 2018 May 10.
Kumar, H., Finer-Moore J. S., Jiang X., Smirnova I., Kasho V., Pardon E., Steyaert J., H Kaback R., and Stroud R. M., "Crystal Structure of a ligand-bound LacY-Nanobody Complex.", Proc Natl Acad Sci U S A, vol. 115, issue 35, pp. 8769-8774, 2018 08 28.
Monté, D., Clantin B., Dewitte F., Lens Z., Rucktooa P., Pardon E., Steyaert J., Verger A., and Villeret V., "Crystal structure of human Mediator subunit MED23.", Nat Commun, vol. 9, issue 1, pp. 3389, 2018 Aug 23.
Stoeber, M., Jullié D., Lobingier B. T., Laeremans T., Steyaert J., Schiller P. W., Manglik A., and von Zastrow M., "A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.", Neuron, vol. 98, issue 5, pp. 963-976.e5, 2018 Jun 06.
Szpakowska, M., Meyrath M., Reynders N., Counson M., Hanson J., Steyaert J., and Chevigné A., "Mutational analysis of the extracellular disulphide bridges of the atypical chemokine receptor ACKR3/CXCR7 uncovers multiple binding and activation modes for its chemokine and endogenous non-chemokine agonists.", Biochem Pharmacol, vol. 153, pp. 299-309, 2018 Jul.
Pardon, E., Betti C., Laeremans T., Chevillard F., Guillemyn K., Kolb P., Ballet S., and Steyaert J., "Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.", Angew Chem Int Ed Engl, vol. 57, issue 19, pp. 5292-5295, 2018 May 04.
Che, T., Majumdar S., Zaidi S. A., Ondachi P., McCorvy J. D., Wang S., Mosier P. D., Uprety R., Vardy E., Krumm B. E., et al., "Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.", Cell, vol. 172, issue 1-2, pp. 55-67.e15, 2018 Jan 11.
Lee, S., Choi J., Mohanty J., Sousa L. P., Tome F., Pardon E., Steyaert J., Lemmon M. A., Lax I., and Schlessinger J., "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
2017
Ayoub, M. Akli, Crépieux P., Koglin M., Parmentier M., Pin J-P., Poupon A., Reiter E., Smit M., Steyaert J., Watier H., et al., "Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges.", MAbs, vol. 9, issue 5, pp. 735-741, 2017 07.
Schacherl, M., Gompert M., Pardon E., Lamkemeyer T., Steyaert J., and Baumann U., "Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.", Biochim Biophys Acta Biomembr, vol. 1859, issue 10, pp. 1859-1871, 2017 Oct.
Joncour, A., Desroy N., Housseman C., Bock X., Bienvenu N., Cherel L., Labeguere V., Peixoto C., Annoot D., Lepissier L., et al., "Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.", J Med Chem, vol. 60, issue 17, pp. 7371-7392, 2017 Sep 14.
Cahill, T. J., Thomsen A. R. B., Tarrasch J. T., Plouffe B., Nguyen A. H., Yang F., Huang L-Y., Kahsai A. W., Bassoni D. L., Gavino B. J., et al., "Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.", Proc Natl Acad Sci U S A, vol. 114, issue 10, pp. 2562-2567, 2017 Mar 07.
Schenck, S., Kunz L., Sahlender D., Pardon E., Geertsma E. R., Savtchouk I., Suzuki T., Neldner Y., Štefanić S., Steyaert J., et al., "Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.", Biochemistry, vol. 56, issue 30, pp. 3962-3971, 2017 08 01.
Barros-Álvarez, X., Kerchner K. M., Koh C. Yeow, Turley S., Pardon E., Steyaert J., Ranade R. M., J Gillespie R., Zhang Z., Verlinde C. L. M. J., et al., "Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.", Biochimie, vol. 138, pp. 124-136, 2017 Jul.
Manglik, A., Kobilka B. K., and Steyaert J., "Nanobodies to Study G Protein-Coupled Receptor Structure and Function.", Annu Rev Pharmacol Toxicol, vol. 57, pp. 19-37, 2017 01 06.
Martin, C., Moors S. L. C., Danielsen M., Betti C., Fabris C., Pedersen D. Sejer, Pardon E., Peyressatre M., Fehér K., Martins J. C., et al., "Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β Adrenergic Receptor Ligands.", Chemistry, vol. 23, issue 40, pp. 9632-9640, 2017 Jul 18.
Abskharon, R., Dang J., Elfarash A., Wang Z., Shen P., Zou L. S., Hassan S., Wang F., Fujioka H., Steyaert J., et al., "Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors.", Microb Cell Fact, vol. 16, issue 1, pp. 170, 2017 Oct 04.
Raimondi, S., Porcari R., P Mangione P., Verona G., Marcoux J., Giorgetti S., Taylor G. W., Ellmerich S., Ballico M., Zanini S., et al., "A specific nanobody prevents amyloidogenesis of D76N β-microglobulin in vitro and modifies its tissue distribution in vivo.", Sci Rep, vol. 7, pp. 46711, 2017 Apr 21.
Wohlkonig, A., Remaut H., Moune M., Tanina A., Meyer F., Desroses M., Steyaert J., Willand N., Baulard A. R., and Wintjens R., "Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.", Biochem Biophys Res Commun, vol. 487, issue 2, pp. 403-408, 2017 05 27.
Singh, R. Kumar, Steyaert J., and Versées W., "Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis.", Protein Sci, vol. 26, issue 5, pp. 985-996, 2017 05.
Miller, P. S., Scott S., Masiulis S., De Colibus L., Pardon E., Steyaert J., and A Aricescu R., "Structural basis for GABA receptor potentiation by neurosteroids.", Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
Perez, C., Köhler M., Janser D., Pardon E., Steyaert J., Zenobi R., and Locher K. P., "Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.", Sci Rep, vol. 7, pp. 46641, 2017 Apr 19.
Schubert, A. F., Gladkova C., Pardon E., Wagstaff J. L., Freund S. M. V., Steyaert J., Maslen S. L., and Komander D., "Structure of PINK1 in complex with its substrate ubiquitin.", Nature, vol. 552, issue 7683, pp. 51-56, 2017 12 07.

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