Publications

Found 138 results
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2018
Talavera, A., J. Hendrix, W. Versées, D. Jurenas, K. Van Nerom, N. Vandenberk, R. Kumar Singh, A. Konijnenberg, S. De Gieter, D. Castro-Roa, et al., "Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.", Sci Adv, vol. 4, issue 3, pp. eaap9714, 2018 Mar.
Zavrtanik, U., J. Lukan, R. Loris, J. Lah, and S. Hadži, "Structural Basis of Epitope Recognition by Heavy Chain Camelid Antibodies.", J Mol Biol, 2018 Sep 08.
2017
Beirnaert, E., A. Desmyter, S. Spinelli, M. Lauwereys, L. Aarden, T. Dreier, R. Loris, K. Silence, C. Pollet, C. Cambillau, et al., "Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.", Front Immunol, vol. 8, pp. 867, 2017.
Burger, V. M., A. Vandervelde, J. Hendrix, A. Konijnenberg, F. Sobott, R. Loris, and C. M. Stultz, "Hidden States within Disordered Regions of the CcdA Antitoxin Protein.", J Am Chem Soc, vol. 139, issue 7, pp. 2693-2701, 2017 02 22.
Vandervelde, A., I. Drobnak, S. Hadži, Y. G. - J. Sterckx, T. Welte, H. De Greve, D. Charlier, R. G. Efremov, R. Loris, and J. Lah, "Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.", Nucleic Acids Res, vol. 45, issue 6, pp. 2937-2950, 2017 Apr 07.
Talavera, A., H. Tamman, A. Ainelo, S. Hadǽi, A. Garcia-Pino, R. Hõrak, A. Konijnenberg, and R. Loris, "Production, biophysical characterization and crystallization of Pseudomonas putida GraA and its complexes with GraT and the graTA operator.", Acta Crystallogr F Struct Biol Commun, vol. 73, issue Pt 8, pp. 455-462, 2017 Aug 01.
Hadži, S., A. Garcia-Pino, S. Haesaerts, D. Jurenas, K. Gerdes, J. Lah, and R. Loris, "Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism.", Nucleic Acids Res, vol. 45, issue 8, pp. 4972-4983, 2017 May 05.
Hadži, S., A. Mernik, Č. Podlipnik, R. Loris, and J. Lah, "The Thermodynamic Basis of the Fuzzy Interaction of an Intrinsically Disordered Protein.", Angew Chem Int Ed Engl, vol. 56, issue 46, pp. 14494-14497, 2017 Nov 13.
2016
Vandervelde, A., R. Loris, J. Danckaert, and L. Gelens, "Computational Methods to Model Persistence.", Methods Mol Biol, vol. 1333, pp. 207-40, 2016.
Egea-Jimenez, A. Luis, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. Maria Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau, and P. Zimmermann, "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.", Nat Commun, vol. 7, pp. 12101, 2016 07 08.
Garcia-Pino, A., S. De Gieter, A. Talavera, H. De Greve, R. G. Efremov, and R. Loris, "An intrinsically disordered entropic switch determines allostery in Phd-Doc regulation.", Nat Chem Biol, vol. 12, issue 7, pp. 490-6, 2016 07.
Blanchetot, C., N. De Jonge, A. Desmyter, N. Ongenae, E. Hofman, A. Klarenbeek, A. Sadi, A. Hultberg, A. Kretz-Rommel, S. Spinelli, et al., "Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.", J Biol Chem, vol. 291, issue 26, pp. 13846-54, 2016 Jun 24.
Zorzini, V., A. Mernik, J. Lah, Y. G. J. Sterckx, N. De Jonge, A. Garcia-Pino, H. De Greve, W. Versées, and R. Loris, "Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.", J Biol Chem, vol. 291, issue 21, pp. 10950-60, 2016 May 20.
Sterckx, Y. G. - J., T. Jové, A. V. Shkumatov, A. Garcia-Pino, L. Geerts, M. De Kerpel, J. Lah, H. De Greve, L. Van Melderen, and R. Loris, "A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex.", J Mol Biol, vol. 428, issue 8, pp. 1589-603, 2016 Apr 24.
2015
Haesaerts, S., J. Alexander Buitrago, R. Loris, D. Baeyens-Volant, and M. Azarkan, "Crystallization and preliminary X-ray analysis of four cysteine proteases from Ficus carica latex.", Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 4, pp. 459-65, 2015 Apr.
Hadži, S., A. Garcia-Pino, K. Gerdes, J. Lah, and R. Loris, "Crystallization of two operator complexes from the Vibrio cholerae HigBA2 toxin-antitoxin module.", Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 2, pp. 226-33, 2015 Feb.
Sterckx, Y. G. - J., S. De Gieter, V. Zorzini, S. Hadži, S. Haesaerts, R. Loris, and A. Garcia-Pino, "An efficient method for the purification of proteins from four distinct toxin-antitoxin modules.", Protein Expr Purif, vol. 108, pp. 30-40, 2015 Apr.
Zorzini, V., L. Buts, E. Schrank, Y. G. J. Sterckx, M. Respondek, H. Engelberg-Kulka, R. Loris, K. Zangger, and N. A. J. van Nuland, "Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding.", Nucleic Acids Res, vol. 43, issue 2, pp. 1241-56, 2015 Jan.
2014
Sterckx, Y. G. J., S. Haesaerts, L. Van Melderen, and R. Loris, "Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 9, pp. 1284-91, 2014 Sep.
Loris, R., and A. Garcia-Pino, "Disorder- and dynamics-based regulatory mechanisms in toxin-antitoxin modules.", Chem Rev, vol. 114, issue 13, pp. 6933-47, 2014 Jul 09.
De Gieter, S., A. Konijnenberg, A. Talavera, A. Butterer, S. Haesaerts, H. De Greve, F. Sobott, R. Loris, and A. Garcia-Pino, "The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.", J Biol Chem, vol. 289, issue 49, pp. 34013-23, 2014 Dec 05.
Garcia-Pino, A., N. Zenkin, and R. Loris, "The many faces of Fic: structural and functional aspects of Fic enzymes.", Trends Biochem Sci, vol. 39, issue 3, pp. 121-9, 2014 Mar.
Bethuyne, J., S. De Gieter, O. Zwaenepoel, A. Garcia-Pino, K. Durinck, A. Verhelle, G. Hassanzadeh-Ghassabeh, F. Speleman, R. Loris, and J. Gettemans, "A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.", Nucleic Acids Res, vol. 42, issue 20, pp. 12928-38, 2014 Nov 10.
Fislage, M., E. Brosens, E. Deyaert, A. Spilotros, E. Pardon, R. Loris, J. Steyaert, A. Garcia-Pino, and W. Versées, "SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization.", Nucleic Acids Res, vol. 42, issue 9, pp. 5978-92, 2014 May.
Sterckx, Y. G. J., A. Volkov, W. F. Vranken, J. Kragelj, M. Ringkjøbi Jensen, L. Buts, A. Garcia-Pino, T. Jové, L. Van Melderen, M. Blackledge, et al., "Small-angle X-ray scattering- and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2.", Structure, vol. 22, issue 6, pp. 854-65, 2014 Jun 10.

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