Publications

Found 130 results
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2016
Vandervelde, A., Loris R., Danckaert J., and Gelens L., "Computational Methods to Model Persistence.", Methods Mol Biol, vol. 1333, pp. 207-40, 2016.
Egea-Jimenez, A. Luis, Gallardo R., Garcia-Pino A., Ivarsson Y., Wawrzyniak A. Maria, Kashyap R., Loris R., Schymkowitz J., Rousseau F., and Zimmermann P., "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.", Nat Commun, vol. 7, pp. 12101, 2016 Jul 08.
Garcia-Pino, A., De Gieter S., Talavera A., De Greve H., Efremov R. G., and Loris R., "An intrinsically disordered entropic switch determines allostery in Phd-Doc regulation.", Nat Chem Biol, vol. 12, issue 7, pp. 490-6, 2016 Jul.
Blanchetot, C., De Jonge N., Desmyter A., Ongenae N., Hofman E., Klarenbeek A., Sadi A., Hultberg A., Kretz-Rommel A., Spinelli S., et al., "Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.", J Biol Chem, vol. 291, issue 26, pp. 13846-54, 2016 Jun 24.
Zorzini, V., Mernik A., Lah J., Sterckx Y. G. J., De Jonge N., Garcia-Pino A., De Greve H., Versées W., and Loris R., "Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.", J Biol Chem, vol. 291, issue 21, pp. 10950-60, 2016 May 20.
Sterckx, Y. G. - J., Jové T., Shkumatov A. V., Garcia-Pino A., Geerts L., De Kerpel M., Lah J., De Greve H., Van Melderen L., and Loris R., "A unique hetero-hexadecameric architecture displayed by the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex.", J Mol Biol, vol. 428, issue 8, pp. 1589-603, 2016 Apr 24.
2015
Haesaerts, S., Buitrago J. Alexander, Loris R., Baeyens-Volant D., and Azarkan M., "Crystallization and preliminary X-ray analysis of four cysteine proteases from Ficus carica latex.", Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 4, pp. 459-65, 2015 Apr.
Hadži, S., Garcia-Pino A., Gerdes K., Lah J., and Loris R., "Crystallization of two operator complexes from the Vibrio cholerae HigBA2 toxin-antitoxin module.", Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 2, pp. 226-33, 2015 Feb.
Sterckx, Y. G. - J., De Gieter S., Zorzini V., Hadži S., Haesaerts S., Loris R., and Garcia-Pino A., "An efficient method for the purification of proteins from four distinct toxin-antitoxin modules.", Protein Expr Purif, vol. 108, pp. 30-40, 2015 Apr.
Zorzini, V., Buts L., Schrank E., Sterckx Y. G. J., Respondek M., Engelberg-Kulka H., Loris R., Zangger K., and van Nuland N. A. J., "Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding.", Nucleic Acids Res, vol. 43, issue 2, pp. 1241-56, 2015 Jan.
2014
Sterckx, Y. G. J., Haesaerts S., Van Melderen L., and Loris R., "Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 9, pp. 1284-91, 2014 Sep.
Loris, R., and Garcia-Pino A., "Disorder- and dynamics-based regulatory mechanisms in toxin-antitoxin modules.", Chem Rev, vol. 114, issue 13, pp. 6933-47, 2014 Jul 09.
De Gieter, S., Konijnenberg A., Talavera A., Butterer A., Haesaerts S., De Greve H., Sobott F., Loris R., and Garcia-Pino A., "The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.", J Biol Chem, vol. 289, issue 49, pp. 34013-23, 2014 Dec 05.
Garcia-Pino, A., Zenkin N., and Loris R., "The many faces of Fic: structural and functional aspects of Fic enzymes.", Trends Biochem Sci, vol. 39, issue 3, pp. 121-9, 2014 Mar.
Bethuyne, J., De Gieter S., Zwaenepoel O., Garcia-Pino A., Durinck K., Verhelle A., Hassanzadeh-Ghassabeh G., Speleman F., Loris R., and Gettemans J., "A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.", Nucleic Acids Res, vol. 42, issue 20, pp. 12928-38, 2014 Nov 10.
Fislage, M., Brosens E., Deyaert E., Spilotros A., Pardon E., Loris R., Steyaert J., Garcia-Pino A., and Versées W., "SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization.", Nucleic Acids Res, vol. 42, issue 9, pp. 5978-92, 2014 May.
Sterckx, Y. G. J., Volkov A.. N., Vranken W. F., Kragelj J., Jensen M. Ringkjøbi, Buts L., Garcia-Pino A., Jové T., Van Melderen L., Blackledge M., et al., "Small-angle X-ray scattering- and nuclear magnetic resonance-derived conformational ensemble of the highly flexible antitoxin PaaA2.", Structure, vol. 22, issue 6, pp. 854-65, 2014 Jun 10.
Zorzini, V., Buts L., Sleutel M., Garcia-Pino A., Talavera A., Haesaerts S., De Greve H., Cheung A., van Nuland N. A. J., and Loris R., "Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics.", Nucleic Acids Res, vol. 42, issue 10, pp. 6709-25, 2014 Jun.
2013
De Gieter, S., Loris R., van Nuland N. A. J., and Garcia-Pino A., "(1)H, (13)C, and (15)N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state.", Biomol NMR Assign, 2013 Feb 19.
Ghequire, M. G. K., De Canck E., Wattiau P., Van Winge I., Loris R., Coenye T., and De Mot R., "Antibacterial activity of a lectin-like Burkholderia cenocepacia protein.", Microbiologyopen, vol. 2, issue 4, pp. 566-75, 2013 Aug.
Hadži, S., Garcia-Pino A., Martinez-Rodriguez S., Verschueren K., Christensen-Dalsgaard M., Gerdes K., Lah J., and Loris R., "Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 9, pp. 1052-9, 2013 Sep.
Drobnak, I., De Jonge N., Haesaerts S., Vesnaver G., Loris R., and Lah J., "Energetic basis of uncoupling folding from binding for an intrinsically disordered protein.", J Am Chem Soc, vol. 135, issue 4, pp. 1288-94, 2013 Jan 30.
Castro-Roa, D., Garcia-Pino A., De Gieter S., van Nuland N. A. J., Loris R., and Zenkin N., "The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu.", Nat Chem Biol, vol. 9, issue 12, pp. 811-7, 2013 Dec.
Gelens, L., Hill L., Vandervelde A., Danckaert J., and Loris R., "A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli.", PLoS Comput Biol, vol. 9, issue 8, pp. e1003190, 2013.
Vuchelen, A., Pardon E., Steyaert J., Gamain B., Loris R., van Nuland N. A. J., and Ramboarina S., "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein. Corrigendum.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 11, pp. 1312, 2013 Nov.

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