Publications

Found 64 results
Filters: Keyword is Mutation  [Clear All Filters]
2018
Wauters, L., S. Terheyden, B. K. Gilsbach, M. Leemans, P. S. Athanasopoulos, G. Guaitoli, A. Wittinghofer, C. Johannes Gloeckner, W. Versées, and A. Kortholt, "Biochemical and kinetic properties of the complex Roco G-protein cycle.", Biol Chem, vol. 399, issue 12, pp. 1447-1456, 2018 11 27.
2017
Nguyen, H. Huy, M. Varadi, P. Tompa, and K. Pauwels, "Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin.", PLoS One, vol. 12, issue 3, pp. e0174125, 2017.
Deyaert, E., L. Wauters, G. Guaitoli, A. Konijnenberg, M. Leemans, S. Terheyden, A. Petrovic, R. Gallardo, L. M. Nederveen-Schippers, P. S. Athanasopoulos, et al., "A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.", Nat Commun, vol. 8, issue 1, pp. 1008, 2017 10 18.
Raimondi, D., G. Orlando, J. Messens, and W. F. Vranken, "Investigating the Molecular Mechanisms Behind Uncharacterized Cysteine Losses from Prediction of Their Oxidation State.", Hum Mutat, vol. 38, issue 1, pp. 86-94, 2017 01.
Willegems, K., and R. G. Efremov, "Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism.", Adv Exp Med Biol, vol. 981, pp. 179-204, 2017.
Schubert, A. F., C. Gladkova, E. Pardon, J. L. Wagstaff, S. M. V. Freund, J. Steyaert, S. L. Maslen, and D. Komander, "Structure of PINK1 in complex with its substrate ubiquitin.", Nature, vol. 552, issue 7683, pp. 51-56, 2017 12 07.
2016
Jiang, X., I. Smirnova, V. Kasho, J. Wu, K. Hirata, M. Ke, E. Pardon, J. Steyaert, N. Yan, and R. H Kaback, "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
Fischer, B., K. Lüthy, J. Paesmans, C. De Koninck, I. Maes, J. Swerts, S. Kuenen, V. Uytterhoeven, P. Verstreken, and W. Versées, "Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.", Nat Struct Mol Biol, vol. 23, issue 11, pp. 965-973, 2016 Nov.
Guaitoli, G., F. Raimondi, B. K. Gilsbach, Y. Gómez-Llorente, E. Deyaert, F. Renzi, X. Li, A. Schaffner, P. Kumar Anku Jagtap, K. Boldt, et al., "Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.", Proc Natl Acad Sci U S A, vol. 113, issue 30, pp. E4357-66, 2016 07 26.
2015
Newman, J. A., P. Savitsky, C. K. Allerston, A. H. Bizard, Ö. Özer, K. Sarlós, Y. Liu, E. Pardon, J. Steyaert, I. D. Hickson, et al., "Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.", Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
Moroz, Y. S., T. T. Dunston, O. V. Makhlynets, O. V. Moroz, Y. Wu, J. H. Yoon, A. B. Olsen, J. M. McLaughlin, K. L. Mack, P. M. Gosavi, et al., "New Tricks for Old Proteins: Single Mutations in a Nonenzymatic Protein Give Rise to Various Enzymatic Activities.", J Am Chem Soc, vol. 137, issue 47, pp. 14905-11, 2015 Dec 02.
2014
Somme, J., B. Van Laer, M. Roovers, J. Steyaert, W. Versées, and L. Droogmans, "Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.", RNA, vol. 20, issue 8, pp. 1257-71, 2014 Aug.
Smirnova, I., V. Kasho, X. Jiang, E. Pardon, J. Steyaert, and R. H Kaback, "Outward-facing conformers of LacY stabilized by nanobodies.", Proc Natl Acad Sci U S A, vol. 111, issue 52, pp. 18548-53, 2014 Dec 30.
2013
Moretti, R., S. J. Fleishman, R. Agius, M. Torchala, P. A. Bates, P. L. Kastritis, J. P. G. L. M. Rodrigues, M. Trellet, A. M. J. J. Bonvin, M. Cui, et al., "Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions.", Proteins, vol. 81, issue 11, pp. 1980-7, 2013 Nov.
Roldan, J. L. Ortega, S. Casares, M. Ringkjøbi Jensen, N. Cárdenes, J. Bravo, M. Blackledge, A. I. Azuaga, and N. A. J. van Nuland, "Distinct ubiquitin binding modes exhibited by SH3 domains: molecular determinants and functional implications.", PLoS One, vol. 8, issue 9, pp. e73018, 2013.
Castro-Roa, D., A. Garcia-Pino, S. De Gieter, N. A. J. van Nuland, R. Loris, and N. Zenkin, "The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu.", Nat Chem Biol, vol. 9, issue 12, pp. 811-7, 2013 Dec.
Vercruysse, T., E. Boons, T. Venken, E. Vanstreels, A. Voet, J. Steyaert, M. De Maeyer, and D. Daelemans, "Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.", PLoS One, vol. 8, issue 4, pp. e60259, 2013.
De Genst, E., P-H. Chan, E. Pardon, S-T. D. Hsu, J. R. Kumita, J. Christodoulou, L. Menzer, D. Y. Chirgadze, C. V. Robinson, S. Muyldermans, et al., "A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.", J Phys Chem B, vol. 117, issue 42, pp. 13245-58, 2013 Oct 24.
2012
Kint, C. I., N. Verstraeten, I. Wens, V. R. Liebens, J. Hofkens, W. Versées, M. Fauvart, and J. Michiels, "The Escherichia coli GTPase ObgE modulates hydroxyl radical levels in response to DNA replication fork arrest.", FEBS J, vol. 279, issue 19, pp. 3692-3704, 2012 Oct.
Eloy, N. B., N. Gonzalez, J. Van Leene, K. Maleux, H. Vanhaeren, L. De Milde, S. Dhondt, L. Vercruysse, E. Witters, R. Mercier, et al., "SAMBA, a plant-specific anaphase-promoting complex/cyclosome regulator is involved in early development and A-type cyclin stabilization.", Proc Natl Acad Sci U S A, vol. 109, issue 34, pp. 13853-8, 2012 Aug 21.
2011
Domanska, K., S. Vanderhaegen, V. Srinivasan, E. Pardon, F. Dupeux, J. A. Marquez, S. Giorgetti, M. Stoppini, L. Wyns, V. Bellotti, et al., "Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.", Proc Natl Acad Sci U S A, vol. 108, issue 4, pp. 1314-9, 2011 Jan 25.
Miśkiewicz, K., L. E. Jose, A. Bento-Abreu, M. Fislage, I. Taes, J. Kasprowicz, J. Swerts, S. Sigrist, W. Versées, W. Robberecht, et al., "ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot.", Neuron, vol. 72, issue 5, pp. 776-88, 2011 Dec 08.
Vercruysse, T., S. Pawar, W. De Borggraeve, E. Pardon, G. N. Pavlakis, C. Pannecouque, J. Steyaert, J. Balzarini, and D. Daelemans, "Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer.", RNA Biol, vol. 8, issue 2, pp. 316-24, 2011 Mar-Apr.
Almeida-Souza, L., B. Asselbergh, C. d'Ydewalle, K. Moonens, S. Goethals, V. de Winter, A. Azmi, J. Irobi, J-P. Timmermans, K. Gevaert, et al., "Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.", J Neurosci, vol. 31, issue 43, pp. 15320-8, 2011 Oct 26.
Korotkov, K. V., T. L. Johnson, M. G. Jobling, J. Pruneda, E. Pardon, A. Héroux, S. Turley, J. Steyaert, R. K. Holmes, M. Sandkvist, et al., "Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.", PLoS Pathog, vol. 7, issue 9, pp. e1002228, 2011 Sep.

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