Publications

Found 61 results
Filters: Keyword is Substrate Specificity  [Clear All Filters]
2018
Singh, R. Kumar, A. Feller, M. Roovers, D. Van Elder, L. Wauters, L. Droogmans, and W. Versées, "Structural and biochemical analysis of the dual-specificity Trm10 enzyme from prompts reconsideration of its catalytic mechanism.", RNA, vol. 24, issue 8, pp. 1080-1092, 2018 08.
Lee, S., J. Choi, J. Mohanty, L. P. Sousa, F. Tome, E. Pardon, J. Steyaert, M. A. Lemmon, I. Lax, and J. Schlessinger, "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
2017
Rosado, L. Astolfi, K. Wahni, G. Degiacomi, B. Pedre, D. Young, A. G. de la Rubia, F. Boldrin, E. Martens, L. Marcos-Pascual, E. Sancho-Vaello, et al., "The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of .", J Biol Chem, vol. 292, issue 32, pp. 13097-13110, 2017 08 11.
2016
Guharoy, M., P. Bhowmick, and P. Tompa, "Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.", J Biol Chem, vol. 291, issue 13, pp. 6723-31, 2016 Mar 25.
Zorzini, V., A. Mernik, J. Lah, Y. G. J. Sterckx, N. De Jonge, A. Garcia-Pino, H. De Greve, W. Versées, and R. Loris, "Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.", J Biol Chem, vol. 291, issue 21, pp. 10950-60, 2016 May 20.
Hariharan, P., M. Andersson, X. Jiang, E. Pardon, J. Steyaert, R. H Kaback, and L. Guan, "Thermodynamics of Nanobody Binding to Lactose Permease.", Biochemistry, vol. 55, issue 42, pp. 5917-5926, 2016 Oct 25.
2015
Sounier, R., C. Mas, J. Steyaert, T. Laeremans, A. Manglik, W. Huang, B. K. Kobilka, H. Déméné, and S. Granier, "Propagation of conformational changes during μ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
2014
Somme, J., B. Van Laer, M. Roovers, J. Steyaert, W. Versées, and L. Droogmans, "Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.", RNA, vol. 20, issue 8, pp. 1257-71, 2014 Aug.
Ehrnstorfer, I. A., E. R. Geertsma, E. Pardon, J. Steyaert, and R. Dutzler, "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.", Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
Denoncin, K., D. Vertommen, I. S. Arts, C. V. Goemans, S. Rahuel-Clermont, J. Messens, and J-F. Collet, "A new role for Escherichia coli DsbC protein in protection against oxidative stress.", J Biol Chem, vol. 289, issue 18, pp. 12356-64, 2014 May 02.
Van Gerven, N., P. Goyal, G. Vandenbussche, M. De Kerpel, W. Jonckheere, H. De Greve, and H. Remaut, "Secretion and functional display of fusion proteins through the curli biogenesis pathway.", Mol Microbiol, vol. 91, issue 5, pp. 1022-35, 2014 Mar.
2013
Ghequire, M. G. K., A. Garcia-Pino, E. K. M. Lebbe, S. Spaepen, R. Loris, and R. De Mot, "Structural determinants for activity and specificity of the bacterial toxin LlpA.", PLoS Pathog, vol. 9, issue 2, pp. e1003199, 2013 Feb.
2012
De Jonge, N., M. Simic, L. Buts, S. Haesaerts, K. Roelants, A. Garcia-Pino, Y. Sterckx, H. De Greve, J. Lah, and R. Loris, "Alternative interactions define gyrase specificity in the CcdB family.", Mol Microbiol, vol. 84, issue 5, pp. 965-78, 2012 Jun.
Villadangos, A. F., H-L. Fu, J. A. Gil, J. Messens, B. P. Rosen, and L. M. Mateos, "Efflux permease CgAcr3-1 of Corynebacterium glutamicum is an arsenite-specific antiporter.", J Biol Chem, vol. 287, issue 1, pp. 723-35, 2012 Jan 02.
Zhu, J., J. Declercq, B. Roucourt, G. H. Ghassabeh, S. Meulemans, J. Kinne, G. David, A. J. M. Vermorken, W. J. M. Van de Ven, I. Lindberg, et al., "Generation and characterization of non-competitive furin-inhibiting nanobodies.", Biochem J, vol. 448, issue 1, pp. 73-82, 2012 Nov 15.
Martinez-Rodriguez, S., A. Garcia-Pino, F. Javier Las Heras-Vázquez, J. María Clemente-Jiménez, F. Rodríguez-Vico, J. M. García-Ruiz, R. Loris, and J. Antonio Gavira, "Mutational and structural analysis of L-N-carbamoylase reveals new insights into a peptidase M20/M25/M40 family member.", J Bacteriol, vol. 194, issue 21, pp. 5759-68, 2012 Nov.
2010
Kardos, J., A. Palló, A. Bencsura, and A. Simon, "Assessing structure, function and druggability of major inhibitory neurotransmitter gamma-aminobutyrate symporter subtypes.", Curr Med Chem, vol. 17, issue 20, pp. 2203-13, 2010.
2009
Ordóñez, E., K. Van Belle, G. Roos, S. De Galan, M. Letek, J. A. Gil, L. Wyns, L. M. Mateos, and J. Messens, "Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.", J Biol Chem, vol. 284, issue 22, pp. 15107-16, 2009 May 29.
Depuydt, M., S. E. Leonard, D. Vertommen, K. Denoncin, P. Morsomme, K. Wahni, J. Messens, K. S. Carroll, and J-F. Collet, "A periplasmic reducing system protects single cysteine residues from oxidation.", Science, vol. 326, issue 5956, pp. 1109-11, 2009 Nov 20.
2008
Kovacs, D., E. Kalmar, Z. Torok, and P. Tompa, "Chaperone activity of ERD10 and ERD14, two disordered stress-related plant proteins.", Plant Physiol, vol. 147, issue 1, pp. 381-90, 2008 May.
Meyer, S., A. Scrima, W. Versées, and A. Wittinghofer, "Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate.", J Mol Biol, vol. 380, issue 3, pp. 532-47, 2008 Jul 11.
Wellens, A., C. Garofalo, H. Nguyen, N. Van Gerven, R. Slättegård, J-P. Hernalsteens, L. Wyns, S. Oscarson, H. De Greve, S. Hultgren, et al., "Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.", PLoS One, vol. 3, issue 4, pp. e2040, 2008.
Rodriguez, S. Martinez, S. Panjikar, K. Van Belle, L. Wyns, J. Messens, and R. Loris, "Nonspecific base recognition mediated by water bridges and hydrophobic stacking in ribonuclease I from Escherichia coli.", Protein Sci, vol. 17, issue 4, pp. 681-90, 2008 Apr.
2007
Spaepen, S., W. Versées, D. Gocke, M. Pohl, J. Steyaert, and J. Vanderleyden, "Characterization of phenylpyruvate decarboxylase, involved in auxin production of Azospirillum brasilense.", J Bacteriol, vol. 189, issue 21, pp. 7626-33, 2007 Nov.
Versées, W., S. Spaepen, J. Vanderleyden, and J. Steyaert, "The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanism.", FEBS J, vol. 274, issue 9, pp. 2363-75, 2007 May.

Pages