Publications
Found 24 results
Filters: Keyword is Substrate Specificity and Author is Jan Steyaert [Clear All Filters]
"Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.",
Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
"Thermodynamics of Nanobody Binding to Lactose Permease.",
Biochemistry, vol. 55, issue 42, pp. 5917-5926, 2016 Oct 25.
"Propagation of conformational changes during μ-opioid receptor activation.",
Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
"Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.",
RNA, vol. 20, issue 8, pp. 1257-71, 2014 Aug.
"Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.",
Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
"Characterization of phenylpyruvate decarboxylase, involved in auxin production of Azospirillum brasilense.",
J Bacteriol, vol. 189, issue 21, pp. 7626-33, 2007 Nov.
"The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanism.",
FEBS J, vol. 274, issue 9, pp. 2363-75, 2007 May.
"Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.",
J Biol Chem, vol. 282, issue 48, pp. 35269-78, 2007 Nov 30.
"Multiple transients in the pre-steady-state of nucleoside hydrolase reveal complex substrate binding, product base release, and two apparent rates of chemistry.",
Biochemistry, vol. 45, issue 30, pp. 9307-18, 2006 Aug 1.
"Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules.",
J Control Release, vol. 102, issue 1, pp. 171-9, 2005 Jan 20.
"Substrate-assisted leaving group activation in enzyme-catalyzed N-glycosidic bond cleavage.",
J Biol Chem, vol. 280, issue 15, pp. 14799-802, 2005 Apr 15.
"Catalysis by nucleoside hydrolases.",
Curr Opin Struct Biol, vol. 13, issue 6, pp. 731-8, 2003 Dec.
"Pre-steady-state analysis of the nucleoside hydrolase of Trypanosoma vivax. Evidence for half-of-the-sites reactivity and rate-limiting product release.",
Biochemistry, vol. 42, issue 44, pp. 12902-8, 2003 Nov 11.
"Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.",
J Biol Chem, vol. 277, issue 18, pp. 15938-46, 2002 May 3.
"A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study.",
J Biol Chem, vol. 277, issue 39, pp. 36770-4, 2002 Sep 27.
"Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.",
J Mol Biol, vol. 307, issue 5, pp. 1363-79, 2001 Apr 13.
"An engineered ribonuclease preferring phosphorothioate RNA.",
Nat Struct Biol, vol. 5, issue 5, pp. 365-8, 1998 May.
"Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography.",
Nat Struct Biol, vol. 5, issue 4, pp. 280-3, 1998 Apr.
"A decade of protein engineering on ribonuclease T1--atomic dissection of the enzyme-substrate interactions.",
Eur J Biochem, vol. 247, issue 1, pp. 1-11, 1997 Jul 1.
"A two-binding-site kinetic model for the ribonuclease-T1-catalysed transesterification of dinucleoside phosphate substrates.",
Eur J Biochem, vol. 233, issue 1, pp. 140-4, 1995 Oct 1.
"Investigation of the functional interplay between the primary site and the subsite of RNase T1: kinetic analysis of single and multiple mutants for modified substrates.",
Proteins, vol. 18, issue 4, pp. 318-23, 1994 Apr.
"Quantitative analysis of the contribution of Glu46 and Asn98 to the guanosine specificity of ribonuclease T1.",
Biochemistry, vol. 30, issue 2, pp. 494-9, 1991 Jan 15.
"Subsite interactions of ribonuclease T1: Asn36 and Asn98 accelerate GpN transesterification through interactions with the leaving nucleoside N.",
Biochemistry, vol. 30, issue 35, pp. 8666-70, 1991 Sep 3.
"Subsite interactions of ribonuclease T1: viscosity effects indicate that the rate-limiting step of GpN transesterification depends on the nature of N.",
Biochemistry, vol. 30, issue 35, pp. 8661-5, 1991 Sep 3.