Publications

Found 29 results
Filters: Keyword is Crystallography, X-Ray and Author is Pardon, Els  [Clear All Filters]
2018
Lee, S., J. Choi, J. Mohanty, L. P. Sousa, F. Tome, E. Pardon, J. Steyaert, M. A. Lemmon, I. Lax, and J. Schlessinger, "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
2017
Miller, P. S., S. Scott, S. Masiulis, L. De Colibus, E. Pardon, J. Steyaert, and R. A Aricescu, "Structural basis for GABA receptor potentiation by neurosteroids.", Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
Schubert, A. F., C. Gladkova, E. Pardon, J. L. Wagstaff, S. M. V. Freund, J. Steyaert, S. L. Maslen, and D. Komander, "Structure of PINK1 in complex with its substrate ubiquitin.", Nature, vol. 552, issue 7683, pp. 51-56, 2017 12 07.
2016
Staus, D. P., R. T. Strachan, A. Manglik, B. Pani, A. W. Kahsai, T. Hun Kim, L. M. Wingler, S. Ahn, A. Chatterjee, A. Masoudi, et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Jiang, X., I. Smirnova, V. Kasho, J. Wu, K. Hirata, M. Ke, E. Pardon, J. Steyaert, N. Yan, and R. H Kaback, "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
2015
Newman, J. A., P. Savitsky, C. K. Allerston, A. H. Bizard, Ö. Özer, K. Sarlós, Y. Liu, E. Pardon, J. Steyaert, I. D. Hickson, et al., "Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.", Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
Moonens, K., I. Van den Broeck, E. Okello, E. Pardon, M. De Kerpel, H. Remaut, and H. De Greve, "Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.", Vet Res, vol. 46, pp. 14, 2015 Feb 24.
Rostislavleva, K., N. Soler, Y. Ohashi, L. Zhang, E. Pardon, J. E. Burke, G. R. Masson, C. Johnson, J. Steyaert, N. T. Ktistakis, et al., "Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.", Science, vol. 350, issue 6257, pp. aac7365, 2015 Oct 09.
Geertsma, E. R., Y-N. Chang, F. R. Shaik, Y. Neldner, E. Pardon, J. Steyaert, and R. Dutzler, "Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 22, issue 10, pp. 803-8, 2015 Oct.
2014
Ehrnstorfer, I. A., E. R. Geertsma, E. Pardon, J. Steyaert, and R. Dutzler, "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.", Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
Lo, A. W. H., K. Moonens, M. De Kerpel, L. Brys, E. Pardon, H. Remaut, and H. De Greve, "The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.", J Biol Chem, vol. 289, issue 36, pp. 25374-81, 2014 Sep 05.
Abskharon, R. N. N., G. Giachin, A. Wohlkonig, S. H. Soror, E. Pardon, G. Legname, and J. Steyaert, "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
2013
De Genst, E., P-H. Chan, E. Pardon, S-T. D. Hsu, J. R. Kumita, J. Christodoulou, L. Menzer, D. Y. Chirgadze, C. V. Robinson, S. Muyldermans, et al., "A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.", J Phys Chem B, vol. 117, issue 42, pp. 13245-58, 2013 Oct 24.
Löw, C., Y. Hoe Yau, E. Pardon, C. Jegerschöld, L. Wåhlin, E. M. Quistgaard, P. Moberg, S. Geifman-Shochat, J. Steyaert, and P. Nordlund, "Nanobody mediated crystallization of an archeal mechanosensitive channel.", PLoS One, vol. 8, issue 10, pp. e77984, 2013.
Vuchelen, A., E. Pardon, J. Steyaert, B. Gamain, R. Loris, N. A. J. van Nuland, and S. Ramboarina, "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 3, pp. 270-4, 2013 Mar 1.
Vanderhaegen, S., M. Fislage, K. Domanska, W. Versées, E. Pardon, V. Bellotti, and J. Steyaert, "Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis.", Protein Sci, vol. 22, issue 10, pp. 1349-57, 2013 Oct.
2012
Park, Y-J., E. Pardon, M. Wu, J. Steyaert, and W. G. J. Hol, "Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody.", Nucleic Acids Res, vol. 40, issue 4, pp. 1828-40, 2012 Feb.
Baranova, E., R. Fronzes, A. Garcia-Pino, N. Van Gerven, D. Papapostolou, G. Péhau-Arnaudet, E. Pardon, J. Steyaert, S. Howorka, and H. Remaut, "SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly.", Nature, vol. 487, issue 7405, pp. 119-22, 2012 Jul 5.
2011
Domanska, K., S. Vanderhaegen, V. Srinivasan, E. Pardon, F. Dupeux, J. A. Marquez, S. Giorgetti, M. Stoppini, L. Wyns, V. Bellotti, et al., "Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.", Proc Natl Acad Sci U S A, vol. 108, issue 4, pp. 1314-9, 2011 Jan 25.
Abskharon, R. N. N., S. H. Soror, E. Pardon, H. El Hassan, G. Legname, J. Steyaert, and A. Wohlkonig, "Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes.", Protein Eng Des Sel, vol. 24, issue 9, pp. 737-41, 2011 Sep.
Rasmussen, S. G. F., B. T. Devree, Y. Zou, A. C. Kruse, K. Young Chung, T. Sun Kobilka, F. Sun Thian, P. Seok Chae, E. Pardon, D. Calinski, et al., "Crystal structure of the β2 adrenergic receptor-Gs protein complex.", Nature, vol. 477, issue 7366, pp. 549-55, 2011 Sep 29.
Westfield, G. H., S. G. F. Rasmussen, M. Su, S. Dutta, B. T. Devree, K. Young Chung, D. Calinski, G. Velez-Ruiz, A. N. Oleskie, E. Pardon, et al., "Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.", Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.
Rasmussen, S. G. F., H-J. Choi, J. Jose Fung, E. Pardon, P. Casarosa, P. Seok Chae, B. T. Devree, D. M. Rosenbaum, F. Sun Thian, T. Sun Kobilka, et al., "Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.", Nature, vol. 469, issue 7329, pp. 175-80, 2011 Jan 13.
Wu, M., Y-J. Park, E. Pardon, S. Turley, A. Hayhurst, J. Deng, J. Steyaert, and W. G. J. Hol, "Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.", J Struct Biol, vol. 174, issue 1, pp. 124-36, 2011 Apr.
2010
Abskharon, R. N. N., S. H. Soror, E. Pardon, H. El Hassan, G. Legname, J. Steyaert, and A. Wohlkonig, "Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 66, issue Pt 12, pp. 1644-6, 2010 Dec 1.

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