Publications

Found 25 results
Filters: Keyword is Crystallography, X-Ray and Author is Wim Versées  [Clear All Filters]
2018
Singh, R. Kumar, A. Feller, M. Roovers, D. Van Elder, L. Wauters, L. Droogmans, and W. Versées, "Structural and biochemical analysis of the dual-specificity Trm10 enzyme from prompts reconsideration of its catalytic mechanism.", RNA, vol. 24, issue 8, pp. 1080-1092, 2018 08.
2017
Rosado, L. Astolfi, K. Wahni, G. Degiacomi, B. Pedre, D. Young, A. G. de la Rubia, F. Boldrin, E. Martens, L. Marcos-Pascual, E. Sancho-Vaello, et al., "The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of .", J Biol Chem, vol. 292, issue 32, pp. 13097-13110, 2017 08 11.
Deyaert, E., A. Kortholt, and W. Versées, "The LRR-Roc-COR module of the Chlorobium tepidum Roco protein: crystallization and X-ray crystallographic analysis.", Acta Crystallogr F Struct Biol Commun, vol. 73, issue Pt 9, pp. 520-524, 2017 Sep 01.
Gkekas, S., R. Kumar Singh, A. V. Shkumatov, J. Messens, M. Fauvart, N. Verstraeten, J. Michiels, and W. Versées, "Structural and biochemical analysis of ObgE, a central regulator of bacterial persistence.", J Biol Chem, vol. 292, issue 14, pp. 5871-5883, 2017 04 07.
Singh, R. Kumar, J. Steyaert, and W. Versées, "Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis.", Protein Sci, vol. 26, issue 5, pp. 985-996, 2017 05.
2016
Fischer, B., K. Lüthy, J. Paesmans, C. De Koninck, I. Maes, J. Swerts, S. Kuenen, V. Uytterhoeven, P. Verstreken, and W. Versées, "Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.", Nat Struct Mol Biol, vol. 23, issue 11, pp. 965-973, 2016 Nov.
Van Laer, B., M. Roovers, L. Wauters, J. M. Kasprzak, M. Dyzma, E. Deyaert, R. Kumar Singh, A. Feller, J. M. Bujnicki, L. Droogmans, et al., "Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue.", Nucleic Acids Res, vol. 44, issue 2, pp. 940-53, 2016 Jan 29.
Guaitoli, G., F. Raimondi, B. K. Gilsbach, Y. Gómez-Llorente, E. Deyaert, F. Renzi, X. Li, A. Schaffner, P. Kumar Anku Jagtap, K. Boldt, et al., "Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.", Proc Natl Acad Sci U S A, vol. 113, issue 30, pp. E4357-66, 2016 07 26.
Zorzini, V., A. Mernik, J. Lah, Y. G. J. Sterckx, N. De Jonge, A. Garcia-Pino, H. De Greve, W. Versées, and R. Loris, "Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.", J Biol Chem, vol. 291, issue 21, pp. 10950-60, 2016 May 20.
2013
Van Laer, K., A. M. Dziewulska, M. Fislage, K. Wahni, A. Hbeddou, J-F. Collet, W. Versées, L. M. Mateos, V. Tamu Dufe, and J. Messens, "NrdH-redoxin of Mycobacterium tuberculosis and Corynebacterium glutamicum dimerizes at high protein concentration and exclusively receives electrons from thioredoxin reductase.", J Biol Chem, vol. 288, issue 11, pp. 7942-55, 2013 Mar 15.
Vanderhaegen, S., M. Fislage, K. Domanska, W. Versées, E. Pardon, V. Bellotti, and J. Steyaert, "Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis.", Protein Sci, vol. 22, issue 10, pp. 1349-57, 2013 Oct.
2012
Fislage, M., M. Roovers, I. Tuszynska, J. M. Bujnicki, L. Droogmans, and W. Versées, "Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life.", Nucleic Acids Res, vol. 40, issue 11, pp. 5149-61, 2012 Jun.
2011
Fislage, M., M. Roovers, S. Münnich, L. Droogmans, and W. Versées, "Crystallization and preliminary X-ray crystallographic analysis of putative tRNA-modification enzymes from Pyrococcus furiosus and Thermus thermophilus.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 67, issue Pt 11, pp. 1432-5, 2011 Nov 01.
2010
Vandemeulebroucke, A., C. Minici, I. Bruno, L. Muzzolini, P. Tornaghi, D. W. Parkin, W. Versées, J. Steyaert, and M. Degano, "Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei.", Biochemistry, vol. 49, issue 41, pp. 8999-9010, 2010 Oct 19.
2009
Versées, W., A. Goeminne, M. Berg, A. Vandemeulebroucke, A. Haemers, K. Augustyns, and J. Steyaert, "Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.", Biochim Biophys Acta, vol. 1794, issue 6, pp. 953-60, 2009 Jun.
2008
Meyer, S., A. Scrima, W. Versées, and A. Wittinghofer, "Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate.", J Mol Biol, vol. 380, issue 3, pp. 532-47, 2008 Jul 11.
2007
Versées, W., S. Spaepen, J. Vanderleyden, and J. Steyaert, "The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanism.", FEBS J, vol. 274, issue 9, pp. 2363-75, 2007 May.
Cordeiro, A. T., A. J. Cáceres, D. Vertommen, J. Luis Concepción, P. A. M. Michels, and W. Versées, "The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes.", J Mol Biol, vol. 372, issue 5, pp. 1215-26, 2007 Oct 05.
Versées, W., S. Spaepen, M. D. H. Wood, F. J. Leeper, J. Vanderleyden, and J. Steyaert, "Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.", J Biol Chem, vol. 282, issue 48, pp. 35269-78, 2007 Nov 30.
2006
Muzzolini, L., W. Versées, P. Tornaghi, E. Van Holsbeke, J. Steyaert, and M. Degano, "New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product.", Biochemistry, vol. 45, issue 3, pp. 773-82, 2006 Jan 24.
Versées, W., J. Barlow, and J. Steyaert, "Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.", J Mol Biol, vol. 359, issue 2, pp. 331-46, 2006 Jun 2.
2004
Versées, W., S. Loverix, A. Vandemeulebroucke, P. Geerlings, and J. Steyaert, "Leaving group activation by aromatic stacking: an alternative to general acid catalysis.", J Mol Biol, vol. 338, issue 1, pp. 1-6, 2004 Apr 16.
2003
Versées, W., E. Van Holsbeke, S. De Vos, K. Decanniere, I. Zegers, and J. Steyaert, "Cloning, preliminary characterization and crystallization of nucleoside hydrolases from Caenorhabditis elegans and Campylobacter jejuni.", Acta Crystallogr D Biol Crystallogr, vol. 59, issue Pt 6, pp. 1087-9, 2003 Jun.
2002
Versées, W., K. Decanniere, E. Van Holsbeke, N. Devroede, and J. Steyaert, "Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.", J Biol Chem, vol. 277, issue 18, pp. 15938-46, 2002 May 03.
2001
Versées, W., K. Decanniere, R. Pellé, J. Depoorter, E. Brosens, D. W. Parkin, and J. Steyaert, "Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.", J Mol Biol, vol. 307, issue 5, pp. 1363-79, 2001 Apr 13.