Publications

Found 294 results
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2017
Nguyen, H. Huy, Varadi M., Tompa P., and Pauwels K., "Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin.", PLoS One, vol. 12, issue 3, pp. e0174125, 2017.
Joncour, A., Desroy N., Housseman C., Bock X., Bienvenu N., Cherel L., Labeguere V., Peixoto C., Annoot D., Lepissier L., et al., "Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.", J Med Chem, vol. 60, issue 17, pp. 7371-7392, 2017 Sep 14.
Schenck, S., Kunz L., Sahlender D., Pardon E., Geertsma E. R., Savtchouk I., Suzuki T., Neldner Y., Štefanić S., Steyaert J., et al., "Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.", Biochemistry, vol. 56, issue 30, pp. 3962-3971, 2017 Aug 01.
Barros-Álvarez, X., Kerchner K. M., Koh C. Yeow, Turley S., Pardon E., Steyaert J., Ranade R. M., J Gillespie R., Zhang Z., Verlinde C. L. M. J., et al., "Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.", Biochimie, vol. 138, pp. 124-136, 2017 Jul.
Boeynaems, S., Bogaert E., Kovacs D., Konijnenberg A., Timmerman E., Volkov A., Guharoy M., De Decker M., Jaspers T., Ryan V. H., et al., "Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.", Mol Cell, vol. 65, issue 6, pp. 1044-1055.e5, 2017 Mar 16.
Miller, P. S., Scott S., Masiulis S., De Colibus L., Pardon E., Steyaert J., and A Aricescu R., "Structural basis for GABAA receptor potentiation by neurosteroids.", Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
Pauwels, K., Lebrun P., and Tompa P., "To be disordered or not to be disordered: is that still a question for proteins in the cell?", Cell Mol Life Sci, vol. 74, issue 17, pp. 3185-3204, 2017 Sep.
2016
Devree, B. T., Mahoney J. P., Vélez-Ruiz G. A., Rasmussen S. G. F., Kuszak A. J., Edwald E., Fung J-J., Manglik A., Masureel M., Du Y., et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Staus, D. P., Strachan R. T., Manglik A., Pani B., Kahsai A. W., Kim T. Hun, Wingler L. M., Ahn S., Chatterjee A., Masoudi A., et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Odongo, S., Sterckx Y. G. J., Stijlemans B., Pillay D., Baltz T., Muyldermans S., and Magez S., "An Anti-proteome Nanobody Library Approach Yields a Specific Immunoassay for Trypanosoma congolense Diagnosis Targeting Glycosomal Aldolase.", PLoS Negl Trop Dis, vol. 10, issue 2, pp. e0004420, 2016 Feb.
Messens, J., "Bioplastic hydroxyl radical trapping.", Nat Chem Biol, vol. 12, issue 5, pp. 307-8, 2016 May.
Pancsa, R., and Tompa P., "Coding Regions of Intrinsic Disorder Accommodate Parallel Functions.", Trends Biochem Sci, vol. 41, issue 11, pp. 898-906, 2016 Nov.
Vandervelde, A., Loris R., Danckaert J., and Gelens L., "Computational Methods to Model Persistence.", Methods Mol Biol, vol. 1333, pp. 207-40, 2016.
Hubin, E., Vanschoenwinkel B., Broersen K., De Deyn P. P., Koedam N., Van Nuland N. A., and Pauwels K., "Could ecosystem management provide a new framework for Alzheimer's disease?", Alzheimers Dement, vol. 12, issue 1, pp. 65-74.e1, 2016 Jan.
Guharoy, M., Bhowmick P., and Tompa P., "Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.", J Biol Chem, vol. 291, issue 13, pp. 6723-31, 2016 Mar 25.
Peyrassol, X., Laeremans T., Gouwy M., Lahura V., Debulpaep M., Van Damme J., Steyaert J., Parmentier M., and Langer I., "Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.", J Immunol, vol. 196, issue 6, pp. 2893-901, 2016 Mar 15.
Ismail, S., Gherardi M-J., Froese A., Zanoun M., Gigoux V., Clerc P., Gaits-Iacovoni F., Steyaert J., Nikolaev V. O., and Fourmy D., "Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.", Biochem Pharmacol, vol. 120, pp. 33-45, 2016 Nov 15.
Fislage, M., Wauters L., and Versées W., "Invited review: MnmE, a GTPase that drives a complex tRNA modification reaction.", Biopolymers, vol. 105, issue 8, pp. 568-79, 2016 Aug.
Piai, A., Calçada E. O., Tarenzi T., Del Grande A., Varadi M., Tompa P., Felli I. C., and Pierattelli R., "Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy.", Biophys J, vol. 110, issue 2, pp. 372-81, 2016 Jan 19.
Fischer, B., Lüthy K., Paesmans J., De Koninck C., Maes I., Swerts J., Kuenen S., Uytterhoeven V., Verstreken P., and Versées W., "Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.", Nat Struct Mol Biol, vol. 23, issue 11, pp. 965-973, 2016 Nov.
Moonens, K., Gideonsson P., Subedi S., Bugaytsova J., Romão E., Mendez M., Nordén J., Fallah M., Rakhimova L., Shevtsova A., et al., "Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.", Cell Host Microbe, vol. 19, issue 1, pp. 55-66, 2016 Jan 13.
Blanchetot, C., De Jonge N., Desmyter A., Ongenae N., Hofman E., Klarenbeek A., Sadi A., Hultberg A., Kretz-Rommel A., Spinelli S., et al., "Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.", J Biol Chem, vol. 291, issue 26, pp. 13846-54, 2016 Jun 24.
Guharoy, M., Bhowmick P., Sallam M., and Tompa P., "Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system.", Nat Commun, vol. 7, pp. 10239, 2016 Jan 06.

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