Publications

Found 33 results
Filters: Keyword is Humans and Author is Jan Steyaert  [Clear All Filters]
2018
Lee, S., J. Choi, J. Mohanty, L. P. Sousa, F. Tome, E. Pardon, J. Steyaert, M. A. Lemmon, I. Lax, and J. Schlessinger, "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
2017
Ayoub, M. Akli, P. Crépieux, M. Koglin, M. Parmentier, J-P. Pin, A. Poupon, E. Reiter, M. Smit, J. Steyaert, H. Watier, et al., "Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges.", MAbs, vol. 9, issue 5, pp. 735-741, 2017 07.
Joncour, A., N. Desroy, C. Housseman, X. Bock, N. Bienvenu, L. Cherel, V. Labeguere, C. Peixoto, D. Annoot, L. Lepissier, et al., "Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.", J Med Chem, vol. 60, issue 17, pp. 7371-7392, 2017 Sep 14.
Schenck, S., L. Kunz, D. Sahlender, E. Pardon, E. R. Geertsma, I. Savtchouk, T. Suzuki, Y. Neldner, S. Štefanić, J. Steyaert, et al., "Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.", Biochemistry, vol. 56, issue 30, pp. 3962-3971, 2017 08 01.
Barros-Álvarez, X., K. M. Kerchner, C. Yeow Koh, S. Turley, E. Pardon, J. Steyaert, R. M. Ranade, R. J Gillespie, Z. Zhang, C. L. M. J. Verlinde, et al., "Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.", Biochimie, vol. 138, pp. 124-136, 2017 Jul.
Manglik, A., B. K. Kobilka, and J. Steyaert, "Nanobodies to Study G Protein-Coupled Receptor Structure and Function.", Annu Rev Pharmacol Toxicol, vol. 57, pp. 19-37, 2017 01 06.
Abskharon, R., J. Dang, A. Elfarash, Z. Wang, P. Shen, L. S. Zou, S. Hassan, F. Wang, H. Fujioka, J. Steyaert, et al., "Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors.", Microb Cell Fact, vol. 16, issue 1, pp. 170, 2017 Oct 04.
Miller, P. S., S. Scott, S. Masiulis, L. De Colibus, E. Pardon, J. Steyaert, and R. A Aricescu, "Structural basis for GABA receptor potentiation by neurosteroids.", Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
2016
Devree, B. T., J. P. Mahoney, G. A. Vélez-Ruiz, S. G. F. Rasmussen, A. J. Kuszak, E. Edwald, J-J. Fung, A. Manglik, M. Masureel, Y. Du, et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Staus, D. P., R. T. Strachan, A. Manglik, B. Pani, A. W. Kahsai, T. Hun Kim, L. M. Wingler, S. Ahn, A. Chatterjee, A. Masoudi, et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Peyrassol, X., T. Laeremans, M. Gouwy, V. Lahura, M. Debulpaep, J. Van Damme, J. Steyaert, M. Parmentier, and I. Langer, "Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.", J Immunol, vol. 196, issue 6, pp. 2893-901, 2016 Mar 15.
Ismail, S., M-J. Gherardi, A. Froese, M. Zanoun, V. Gigoux, P. Clerc, F. Gaits-Iacovoni, J. Steyaert, V. O. Nikolaev, and D. Fourmy, "Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.", Biochem Pharmacol, vol. 120, pp. 33-45, 2016 Nov 15.
Zhan, Y-A., R. Abskharon, Y. Li, J. Yuan, L. Zeng, J. Dang, M. Camacho Martinez, Z. Wang, J. Mikol, S. Lehmann, et al., "Quiescin-sulfhydryl oxidase inhibits prion formation .", Aging (Albany NY), vol. 8, issue 12, pp. 3419-3429, 2016 12 11.
Massa, S., N. Vikani, C. Betti, S. Ballet, S. Vanderhaegen, J. Steyaert, B. Descamps, C. Vanhove, A. Bunschoten, F. W. B. van Leeuwen, et al., "Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.", Contrast Media Mol Imaging, vol. 11, issue 5, pp. 328-339, 2016 09.
2015
Lan, T-H., Q. Liu, C. Li, G. Wu, J. Steyaert, and N. A. Lambert, "BRET evidence that β2 adrenergic receptors do not oligomerize in cells.", Sci Rep, vol. 5, pp. 10166, 2015 May 08.
2014
Ehrnstorfer, I. A., E. R. Geertsma, E. Pardon, J. Steyaert, and R. Dutzler, "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.", Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
Nunes-Silva, S., S. Gangnard, M. Vidal, A. Vuchelen, S. Dechavanne, S. Chan, E. Pardon, J. Steyaert, S. Ramboarina, A. Chêne, et al., "Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.", Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
Abskharon, R. N. N., G. Giachin, A. Wohlkonig, S. H. Soror, E. Pardon, G. Legname, and J. Steyaert, "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
Triest, S., A. Wohlkonig, E. Pardon, and J. Steyaert, "Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 11, pp. 1504-7, 2014 Nov.
Staus, D. P., L. M. Wingler, R. T. Strachan, S. G. F. Rasmussen, E. Pardon, S. Ahn, J. Steyaert, B. K. Kobilka, and R. J. Lefkowitz, "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.
2013
Kruse, A. C., A. M. Ring, A. Manglik, J. Hu, K. Hu, K. Eitel, H. Hübner, E. Pardon, C. Valant, P. M. Sexton, et al., "Activation and allosteric modulation of a muscarinic acetylcholine receptor.", Nature, vol. 504, issue 7478, pp. 101-6, 2013 Dec 05.
Irannejad, R., J. C. Tomshine, J. R. Tomshine, M. Chevalier, J. P. Mahoney, J. Steyaert, S. G. F. Rasmussen, R. K. Sunahara, H. El-Samad, B. Huang, et al., "Conformational biosensors reveal GPCR signalling from endosomes.", Nature, vol. 495, issue 7442, pp. 534-8, 2013 Mar 28.
Vercruysse, T., E. Boons, T. Venken, E. Vanstreels, A. Voet, J. Steyaert, M. De Maeyer, and D. Daelemans, "Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.", PLoS One, vol. 8, issue 4, pp. e60259, 2013.
Banner, D. W., B. Gsell, J. Benz, J. Bertschinger, D. Burger, S. Brack, S. Cuppuleri, M. Debulpaep, A. Gast, D. Grabulovski, et al., "Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.", Acta Crystallogr D Biol Crystallogr, vol. 69, issue Pt 6, pp. 1124-37, 2013 Jun.
2012
Abskharon, R. N. N., S. Ramboarina, H. El Hassan, W. Gad, M. I. Apostol, G. Giachin, G. Legname, J. Steyaert, J. Messens, S. H. Soror, et al., "A novel expression system for production of soluble prion proteins in E. coli.", Microb Cell Fact, vol. 11, pp. 6, 2012 Jan 10.

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