Publications
Found 36 results
Filters: Keyword is Catalytic Domain [Clear All Filters]
"Structural and biochemical analysis of the dual-specificity Trm10 enzyme from prompts reconsideration of its catalytic mechanism.",
RNA, vol. 24, issue 8, pp. 1080-1092, 2018 08.
"The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of .",
J Biol Chem, vol. 292, issue 32, pp. 13097-13110, 2017 08 11.
"Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.",
Biochimie, vol. 138, pp. 124-136, 2017 Jul.
"Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism.",
Nucleic Acids Res, vol. 45, issue 8, pp. 4972-4983, 2017 May 05.
"Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis.",
Protein Sci, vol. 26, issue 5, pp. 985-996, 2017 05.
"The active site architecture in peroxiredoxins: a case study on Mycobacterium tuberculosis AhpE.",
Chem Commun (Camb), vol. 52, issue 67, pp. 10293-6, 2016 Aug 11.
"Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue.",
Nucleic Acids Res, vol. 44, issue 2, pp. 940-53, 2016 Jan 29.
"Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.",
Proc Natl Acad Sci U S A, vol. 113, issue 30, pp. E4357-66, 2016 07 26.
"Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.",
J Biol Chem, vol. 291, issue 21, pp. 10950-60, 2016 May 20.
"Corynebacterium diphtheriae methionine sulfoxide reductase a exploits a unique mycothiol redox relay mechanism.",
J Biol Chem, vol. 290, issue 18, pp. 11365-75, 2015 May 01.
"The concerted action of a positive charge and hydrogen bonds dynamically regulates the pKa of the nucleophilic cysteine in the NrdH-redoxin family.",
Protein Sci, vol. 23, issue 2, pp. 238-42, 2014 Feb.
"Inhibition of ligand exchange kinetics via active-site trapping with an antibody fragment.",
Biochemistry, vol. 53, issue 12, pp. 1879-81, 2014 Apr 01.
"SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization.",
Nucleic Acids Res, vol. 42, issue 9, pp. 5978-92, 2014 May.
"Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.",
Biochem J, vol. 459, issue 1, pp. 59-69, 2014 Apr 1.
"Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.",
Biochem J, vol. 450, issue 3, pp. 477-86, 2013 Mar 15.
"The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain.",
Mol Microbiol, vol. 90, issue 2, pp. 267-77, 2013 Oct.
"Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.",
Acta Crystallogr D Biol Crystallogr, vol. 69, issue Pt 6, pp. 1124-37, 2013 Jun.
"Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.",
Biochim Biophys Acta, vol. 1834, issue 10, pp. 2147-57, 2013 Oct.
"NrdH-redoxin of Mycobacterium tuberculosis and Corynebacterium glutamicum dimerizes at high protein concentration and exclusively receives electrons from thioredoxin reductase.",
J Biol Chem, vol. 288, issue 11, pp. 7942-55, 2013 Mar 15.
"Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.",
Science, vol. 337, issue 6093, pp. 463-6, 2012 Jul 27.
"A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes.",
Nat Biotechnol, vol. 30, issue 12, pp. 1225-31, 2012 Dec.
"Mutational and structural analysis of L-N-carbamoylase reveals new insights into a peptidase M20/M25/M40 family member.",
J Bacteriol, vol. 194, issue 21, pp. 5759-68, 2012 Nov.
"Crystal structure of the β2 adrenergic receptor-Gs protein complex.",
Nature, vol. 477, issue 7366, pp. 549-55, 2011 Sep 29.
"The conserved active site tryptophan of thioredoxin has no effect on its redox properties.",
Protein Sci, vol. 19, issue 1, pp. 190-4, 2010 Jan.
"Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70.",
Biochem J, vol. 432, issue 3, pp. 495-504, 2010 Dec 15.