Publications
Found 58 results
Filters: Keyword is Structure-Activity Relationship [Clear All Filters]
"Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains.",
Int J Mol Sci, vol. 20, issue 9, 2019 Apr 29.
"Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.",
J Med Chem, vol. 60, issue 17, pp. 7371-7392, 2017 Sep 14.
"Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.",
Biochem Biophys Res Commun, vol. 487, issue 2, pp. 403-408, 2017 05 27.
"Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism.",
Adv Exp Med Biol, vol. 981, pp. 179-204, 2017.
"Coding Regions of Intrinsic Disorder Accommodate Parallel Functions.",
Trends Biochem Sci, vol. 41, issue 11, pp. 898-906, 2016 Nov.
"Propagation of conformational changes during μ-opioid receptor activation.",
Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
"Structural insights into µ-opioid receptor activation.",
Nature, vol. 524, issue 7565, pp. 315-21, 2015 Aug 20.
"Deciphering fine molecular details of proteins' structure and function with a Protein Surface Topography (PST) method.",
J Chem Inf Model, vol. 54, issue 4, pp. 1189-99, 2014 Apr 28.
"Introducing protein intrinsic disorder.",
Chem Rev, vol. 114, issue 13, pp. 6561-88, 2014 Jul 09.
"Mechanism of Tc toxin action revealed in molecular detail.",
Nature, vol. 508, issue 7494, pp. 61-5, 2014 Apr 03.
"Synonymous constraint elements show a tendency to encode intrinsically disordered protein segments.",
PLoS Comput Biol, vol. 10, issue 5, pp. e1003607, 2014 May.
"Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.",
Cancer Cell, vol. 23, issue 4, pp. 489-501, 2013 Apr 15.
"Novel therapy based on camelid nanobodies.",
Ther Deliv, vol. 4, issue 10, pp. 1321-36, 2013 Oct.
"Structural determinants for activity and specificity of the bacterial toxin LlpA.",
PLoS Pathog, vol. 9, issue 2, pp. e1003199, 2013 Feb.
"The coupling mechanism of respiratory complex I - a structural and evolutionary perspective.",
Biochim Biophys Acta, vol. 1817, issue 10, pp. 1785-95, 2012 Oct.
"The architecture of respiratory complex I.",
Nature, vol. 465, issue 7297, pp. 441-5, 2010 May 27.
"Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity.",
J Med Chem, vol. 53, issue 15, pp. 5690-5, 2010 Aug 12.
"Lead generation and optimization based on protein-ligand complementarity.",
Molecules, vol. 15, issue 6, pp. 4382-400, 2010 Jun.
"Power law distribution defines structural disorder as a structural element directly linked with function.",
J Mol Biol, vol. 403, issue 3, pp. 346-50, 2010 Oct 29.
"Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei.",
Biochemistry, vol. 49, issue 41, pp. 8999-9010, 2010 Oct 19.
"Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases.",
Biochemistry, vol. 48, issue 47, pp. 11252-63, 2009 Dec 1.
"Empirical estimation of the energetic contribution of individual interface residues in structures of protein-protein complexes.",
J Comput Aided Mol Des, vol. 23, issue 9, pp. 645-54, 2009 Sep.
"N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase.",
Bioorg Med Chem, vol. 16, issue 14, pp. 6752-63, 2008 Jul 15.
"Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r.",
Mol Immunol, vol. 45, issue 6, pp. 1752-60, 2008 Mar.
"Role of the amino acid sequence in domain swapping of the B1 domain of protein G.",
Proteins, vol. 72, issue 1, pp. 88-104, 2008 Jul.