Publications

Found 54 results
Filters: Keyword is Single-Domain Antibodies  [Clear All Filters]
2016
Staus, D. P., Strachan R. T., Manglik A., Pani B., Kahsai A. W., Kim T. Hun, Wingler L. M., Ahn S., Chatterjee A., Masoudi A., et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Peyrassol, X., Laeremans T., Gouwy M., Lahura V., Debulpaep M., Van Damme J., Steyaert J., Parmentier M., and Langer I., "Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.", J Immunol, vol. 196, issue 6, pp. 2893-901, 2016 Mar 15.
Wijckmans, E., Nys M., Debaveye S., Brams M., Pardon E., Willegems K., Bertrand D., Steyaert J., Efremov R. G., and Ulens C., "Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues.", PLoS One, vol. 11, issue 3, pp. e0151183, 2016.
Ismail, S., Gherardi M-J., Froese A., Zanoun M., Gigoux V., Clerc P., Gaits-Iacovoni F., Steyaert J., Nikolaev V. O., and Fourmy D., "Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.", Biochem Pharmacol, vol. 120, pp. 33-45, 2016 Nov 15.
Claes, K., Vandewalle K., Laukens B., Laeremans T., Vosters O., Langer I., Parmentier M., Steyaert J., and Callewaert N., "Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.", ACS Synth Biol, vol. 5, issue 10, pp. 1070-1075, 2016 10 21.
Hariharan, P., Andersson M., Jiang X., Pardon E., Steyaert J., H Kaback R., and Guan L., "Thermodynamics of Nanobody Binding to Lactose Permease.", Biochemistry, vol. 55, issue 42, pp. 5917-5926, 2016 Oct 25.
2014
Pathare, G. Ramnath, Nagy I., Śledź P., Anderson D. J., Zhou H-J., Pardon E., Steyaert J., Förster F., Bracher A., and Baumeister W., "Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.", Proc Natl Acad Sci U S A, vol. 111, issue 8, pp. 2984-9, 2014 Feb 25.
Pardon, E., Laeremans T., Triest S., Rasmussen S. G. F., Wohlkonig A., Ruf A., Muyldermans S., Hol W. G. J., Kobilka B. K., and Steyaert J., "A general protocol for the generation of Nanobodies for structural biology.", Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
Hendrickx, M. L. V., Zatloukalova M., Hassanzadeh-Ghassabeh G., Muyldermans S., Gils A., and Declerck P. J., "Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application.", J Thromb Haemost, vol. 12, issue 2, pp. 229-36, 2014 Feb.
Lemaire, M., D'Huyvetter M., Lahoutte T., Van Valckenborgh E., Menu E., De Bruyne E., Kronenberger P., Wernery U., Muyldermans S., Devoogdt N., et al., "Imaging and radioimmunotherapy of multiple myeloma with anti-idiotypic Nanobodies.", Leukemia, vol. 28, issue 2, pp. 444-7, 2014 Feb.
Oyen, D., Steyaert J., and Barlow J. N., "Inhibition of ligand exchange kinetics via active-site trapping with an antibody fragment.", Biochemistry, vol. 53, issue 12, pp. 1879-81, 2014 Apr 01.
Nunes-Silva, S., Gangnard S., Vidal M., Vuchelen A., Dechavanne S., Chan S., Pardon E., Steyaert J., Ramboarina S., Chêne A., et al., "Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.", Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
Zheng, F., Put S., Bouwens L., Lahoutte T., Matthys P., Muyldermans S., De Baetselier P., Devoogdt N., Raes G., and Schoonooghe S., "Molecular imaging with macrophage CRIg-targeting nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis.", J Nucl Med, vol. 55, issue 5, pp. 824-9, 2014 May.
Lo, A. W. H., Moonens K., De Kerpel M., Brys L., Pardon E., Remaut H., and De Greve H., "The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.", J Biol Chem, vol. 289, issue 36, pp. 25374-81, 2014 Sep 05.
Moonens, K., De Kerpel M., Coddens A., Cox E., Pardon E., Remaut H., and De Greve H., "Nanobody mediated inhibition of attachment of F18 Fimbriae expressing Escherichia coli.", PLoS One, vol. 9, issue 12, pp. e114691, 2014.
Bethuyne, J., De Gieter S., Zwaenepoel O., Garcia-Pino A., Durinck K., Verhelle A., Hassanzadeh-Ghassabeh G., Speleman F., Loris R., and Gettemans J., "A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.", Nucleic Acids Res, vol. 42, issue 20, pp. 12928-38, 2014 Nov 10.
De Meyer, T., Muyldermans S., and Depicker A., "Nanobody-based products as research and diagnostic tools.", Trends Biotechnol, vol. 32, issue 5, pp. 263-70, 2014 May.
Abskharon, R. N. N., Giachin G., Wohlkonig A., Soror S. H., Pardon E., Legname G., and Steyaert J., "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
Triest, S., Wohlkonig A., Pardon E., and Steyaert J., "Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 11, pp. 1504-7, 2014 Nov.
Staus, D. P., Wingler L. M., Strachan R. T., Rasmussen S. G. F., Pardon E., Ahn S., Steyaert J., Kobilka B. K., and Lefkowitz R. J., "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.

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