Publications

Found 28 results
Filters: Keyword is Single-Domain Antibodies and Author is Jan Steyaert  [Clear All Filters]
2016
Staus, D. P., R. T. Strachan, A. Manglik, B. Pani, A. W. Kahsai, T. Hun Kim, L. M. Wingler, S. Ahn, A. Chatterjee, A. Masoudi, et al., "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.", Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
Jiang, X., I. Smirnova, V. Kasho, J. Wu, K. Hirata, M. Ke, E. Pardon, J. Steyaert, N. Yan, and R. H Kaback, "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
Peyrassol, X., T. Laeremans, M. Gouwy, V. Lahura, M. Debulpaep, J. Van Damme, J. Steyaert, M. Parmentier, and I. Langer, "Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.", J Immunol, vol. 196, issue 6, pp. 2893-901, 2016 Mar 15.
Wijckmans, E., M. Nys, S. Debaveye, M. Brams, E. Pardon, K. Willegems, D. Bertrand, J. Steyaert, R. G. Efremov, and C. Ulens, "Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues.", PLoS One, vol. 11, issue 3, pp. e0151183, 2016.
Ismail, S., M-J. Gherardi, A. Froese, M. Zanoun, V. Gigoux, P. Clerc, F. Gaits-Iacovoni, J. Steyaert, V. O. Nikolaev, and D. Fourmy, "Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes.", Biochem Pharmacol, vol. 120, pp. 33-45, 2016 Nov 15.
Claes, K., K. Vandewalle, B. Laukens, T. Laeremans, O. Vosters, I. Langer, M. Parmentier, J. Steyaert, and N. Callewaert, "Modular Integrated Secretory System Engineering in Pichia pastoris To Enhance G-Protein Coupled Receptor Expression.", ACS Synth Biol, vol. 5, issue 10, pp. 1070-1075, 2016 10 21.
Massa, S., N. Vikani, C. Betti, S. Ballet, S. Vanderhaegen, J. Steyaert, B. Descamps, C. Vanhove, A. Bunschoten, F. W. B. van Leeuwen, et al., "Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.", Contrast Media Mol Imaging, vol. 11, issue 5, pp. 328-339, 2016 09.
Hariharan, P., M. Andersson, X. Jiang, E. Pardon, J. Steyaert, R. H Kaback, and L. Guan, "Thermodynamics of Nanobody Binding to Lactose Permease.", Biochemistry, vol. 55, issue 42, pp. 5917-5926, 2016 Oct 25.
2014
Pathare, G. Ramnath, I. Nagy, P. Śledź, D. J. Anderson, H-J. Zhou, E. Pardon, J. Steyaert, F. Förster, A. Bracher, and W. Baumeister, "Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.", Proc Natl Acad Sci U S A, vol. 111, issue 8, pp. 2984-9, 2014 Feb 25.
Pardon, E., T. Laeremans, S. Triest, S. G. F. Rasmussen, A. Wohlkonig, A. Ruf, S. Muyldermans, W. G. J. Hol, B. K. Kobilka, and J. Steyaert, "A general protocol for the generation of Nanobodies for structural biology.", Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
Oyen, D., J. Steyaert, and J. N. Barlow, "Inhibition of ligand exchange kinetics via active-site trapping with an antibody fragment.", Biochemistry, vol. 53, issue 12, pp. 1879-81, 2014 Apr 01.
Nunes-Silva, S., S. Gangnard, M. Vidal, A. Vuchelen, S. Dechavanne, S. Chan, E. Pardon, J. Steyaert, S. Ramboarina, A. Chêne, et al., "Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.", Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
Abskharon, R. N. N., G. Giachin, A. Wohlkonig, S. H. Soror, E. Pardon, G. Legname, and J. Steyaert, "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
Triest, S., A. Wohlkonig, E. Pardon, and J. Steyaert, "Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 11, pp. 1504-7, 2014 Nov.
Staus, D. P., L. M. Wingler, R. T. Strachan, S. G. F. Rasmussen, E. Pardon, S. Ahn, J. Steyaert, B. K. Kobilka, and R. J. Lefkowitz, "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.

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