Publications

Found 19 results
Filters: Keyword is Enzyme Inhibitors  [Clear All Filters]
2013
Sohier, J. S., C. Laurent, A. Chevigné, E. Pardon, V. Srinivasan, U. Wernery, P. Lassaux, J. Steyaert, and M. Galleni, "Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.", Biochem J, vol. 450, issue 3, pp. 477-86, 2013 Mar 15.
2011
Oyen, D., V. Srinivasan, J. Steyaert, and J. N. Barlow, "Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.", J Mol Biol, vol. 407, issue 1, pp. 138-48, 2011 Mar 18.
Azarkan, M., S. Martinez-Rodriguez, L. Buts, D. Baeyens-Volant, and A. Garcia-Pino, "The plasticity of the β-trefoil fold constitutes an evolutionary platform for protease inhibition.", J Biol Chem, vol. 286, issue 51, pp. 43726-34, 2011 Dec 23.
2010
Ogata, K., T. Isomura, S. Kawata, H. Yamashita, H. Kubodera, and S. J. Wodak, "Lead generation and optimization based on protein-ligand complementarity.", Molecules, vol. 15, issue 6, pp. 4382-400, 2010 Jun.
Vercheval, L., C. Bauvois, A. di Paolo, F. Borel, J-L. Ferrer, E. Sauvage, A. Matagne, J-M. Frère, P. Charlier, M. Galleni, et al., "Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70.", Biochem J, vol. 432, issue 3, pp. 495-504, 2010 Dec 15.
Yuan, J., Y. Sterckx, L. A. Mitchenall, A. Maxwell, R. Loris, and M. K. Waldor, "Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors.", J Biol Chem, vol. 285, issue 51, pp. 40397-408, 2010 Dec 17.
2009
Versées, W., A. Goeminne, M. Berg, A. Vandemeulebroucke, A. Haemers, K. Augustyns, and J. Steyaert, "Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.", Biochim Biophys Acta, vol. 1794, issue 6, pp. 953-60, 2009 Jun.
Beck, J., L. Vercheval, C. Bebrone, A. Herteg-Fernea, P. Lassaux, and J. Marchand-Brynaert, "Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate.", Bioorg Med Chem Lett, vol. 19, issue 13, pp. 3593-7, 2009 Jul 1.
Berg, M., G. Bal, A. Goeminne, P. Van der Veken, W. Versées, J. Steyaert, A. Haemers, and K. Augustyns, "Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors.", ChemMedChem, vol. 4, issue 2, pp. 249-60, 2009 Feb.
2008
Kiss, R., D. Kovacs, P. Tompa, and A. Perczel, "Local structural preferences of calpastatin, the intrinsically unstructured protein inhibitor of calpain.", Biochemistry, vol. 47, issue 26, pp. 6936-45, 2008 Jul 1.
Goeminne, A., M. Berg, M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, et al., "N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase.", Bioorg Med Chem, vol. 16, issue 14, pp. 6752-63, 2008 Jul 15.
Goeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, and K. Augustyns, "Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.", Eur J Med Chem, vol. 43, issue 2, pp. 315-26, 2008 Feb.
2007
Goeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, S. Apers, A. Haemers, et al., "1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.", Bioorg Med Chem Lett, vol. 17, issue 9, pp. 2523-6, 2007 May 1.
2003
Loverix, S., and J. Steyaert, "Ribonucleases: from prototypes to therapeutic targets?", Curr Med Chem, vol. 10, issue 9, pp. 779-85, 2003 May.
2002
Messens, J., J. C. Martins, E. Brosens, K. Van Belle, D. M. Jacobs, R. Willem, and L. Wyns, "Kinetics and active site dynamics of Staphylococcus aureus arsenate reductase.", J Biol Inorg Chem, vol. 7, issue 1-2, pp. 146-56, 2002 Jan.
1998
Transue, T. R., E. De Genst, M. A. Ghahroudi, L. Wyns, and S. Muyldermans, "Camel single-domain antibody inhibits enzyme by mimicking carbohydrate substrate.", Proteins, vol. 32, issue 4, pp. 515-22, 1998 Sep 1.
Dao-Thi, M-H., L. Wyns, F. Poortmans, E. M. Bahassi, M. Couturier, and R. Loris, "Crystallization of ccdB.", Acta Crystallogr D Biol Crystallogr, vol. 54, issue Pt 5, pp. 975-81, 1998 Sep 1.
Lauwereys, M., A. M Ghahroudi, A. Desmyter, J. Kinne, W. Hölzer, E. De Genst, L. Wyns, and S. Muyldermans, "Potent enzyme inhibitors derived from dromedary heavy-chain antibodies.", EMBO J, vol. 17, issue 13, pp. 3512-20, 1998 Jul 1.
1995
Kajava, A. V., G. Vassart, and S. J. Wodak, "Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats.", Structure, vol. 3, issue 9, pp. 867-77, 1995 Sep 15.