Publications
Found 19 results
Filters: Keyword is Enzyme Inhibitors [Clear All Filters]
"Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.",
Biochem J, vol. 450, issue 3, pp. 477-86, 2013 Mar 15.
"Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.",
J Mol Biol, vol. 407, issue 1, pp. 138-48, 2011 Mar 18.
"The plasticity of the β-trefoil fold constitutes an evolutionary platform for protease inhibition.",
J Biol Chem, vol. 286, issue 51, pp. 43726-34, 2011 Dec 23.
"Lead generation and optimization based on protein-ligand complementarity.",
Molecules, vol. 15, issue 6, pp. 4382-400, 2010 Jun.
"Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys70.",
Biochem J, vol. 432, issue 3, pp. 495-504, 2010 Dec 15.
"Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors.",
J Biol Chem, vol. 285, issue 51, pp. 40397-408, 2010 Dec 17.
"Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.",
Biochim Biophys Acta, vol. 1794, issue 6, pp. 953-60, 2009 Jun.
"Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate.",
Bioorg Med Chem Lett, vol. 19, issue 13, pp. 3593-7, 2009 Jul 1.
"Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors.",
ChemMedChem, vol. 4, issue 2, pp. 249-60, 2009 Feb.
"Local structural preferences of calpastatin, the intrinsically unstructured protein inhibitor of calpain.",
Biochemistry, vol. 47, issue 26, pp. 6936-45, 2008 Jul 1.
"N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase.",
Bioorg Med Chem, vol. 16, issue 14, pp. 6752-63, 2008 Jul 15.
"Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.",
Eur J Med Chem, vol. 43, issue 2, pp. 315-26, 2008 Feb.
"1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.",
Bioorg Med Chem Lett, vol. 17, issue 9, pp. 2523-6, 2007 May 1.
"Ribonucleases: from prototypes to therapeutic targets?",
Curr Med Chem, vol. 10, issue 9, pp. 779-85, 2003 May.
"Kinetics and active site dynamics of Staphylococcus aureus arsenate reductase.",
J Biol Inorg Chem, vol. 7, issue 1-2, pp. 146-56, 2002 Jan.
"Camel single-domain antibody inhibits enzyme by mimicking carbohydrate substrate.",
Proteins, vol. 32, issue 4, pp. 515-22, 1998 Sep 1.
"Crystallization of ccdB.",
Acta Crystallogr D Biol Crystallogr, vol. 54, issue Pt 5, pp. 975-81, 1998 Sep 1.
"Potent enzyme inhibitors derived from dromedary heavy-chain antibodies.",
EMBO J, vol. 17, issue 13, pp. 3512-20, 1998 Jul 1.
"Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats.",
Structure, vol. 3, issue 9, pp. 867-77, 1995 Sep 15.