Publications

Found 45 results
Filters: Keyword is Immunoglobulin Heavy Chains  [Clear All Filters]
2014
Obishakin, E., Stijlemans B., Santi-Rocca J., Vandenberghe I., Devreese B., Muldermans S., Bastin P., and Magez S., "Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes.", PLoS One, vol. 9, issue 12, pp. e115893, 2014.
Ditlev, S. B., Florea R., Nielsen M. A., Theander T. G., Magez S., Boeuf P., and Salanti A., "Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA.", PLoS One, vol. 9, issue 1, pp. e84981, 2014.
2013
Muyldermans, S., "Nanobodies: natural single-domain antibodies.", Annu Rev Biochem, vol. 82, pp. 775-97, 2013.
Butler, J. E., Wertz N., Sun X-Z., Lunney J. K., and Muyldermans S., "Resolution of an immunodiagnostic dilemma: heavy chain chimeric antibodies for species in which plasmocytomas are unknown.", Mol Immunol, vol. 53, issue 1-2, pp. 140-8, 2013 Jan.
2012
Govaert, J., Pellis M., Deschacht N., Vincke C., Conrath K., Muyldermans S., and Saerens D., "Dual beneficial effect of interloop disulfide bond for single domain antibody fragments.", J Biol Chem, vol. 287, issue 3, pp. 1970-9, 2012 Jan 13.
Vincke, C., Gutiérrez C., Wernery U., Devoogdt N., Hassanzadeh-Ghassabeh G., and Muyldermans S., "Generation of single domain antibody fragments derived from camelids and generation of manifold constructs.", Methods Mol Biol, vol. 907, pp. 145-76, 2012.
Vincke, C., and Muyldermans S., "Introduction to heavy chain antibodies and derived Nanobodies.", Methods Mol Biol, vol. 911, pp. 15-26, 2012.
2011
Flajnik, M. F., Deschacht N., and Muyldermans S., "A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?", PLoS Biol, vol. 9, issue 8, pp. e1001120, 2011 Aug.
Ben Abderrazek, R., Vincke C., Hmila I., Saerens D., Abidi N., Ayeb M. El, Muyldermans S., and Bouhaouala-Zahar B., "Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII scorpion toxin.", Protein Eng Des Sel, vol. 24, issue 9, pp. 727-35, 2011 Sep.
2010
Ryckaert, S., Pardon E., Steyaert J., and Callewaert N., "Isolation of antigen-binding camelid heavy chain antibody fragments (nanobodies) from an immune library displayed on the surface of Pichia pastoris.", J Biotechnol, vol. 145, issue 2, pp. 93-8, 2010 Jan 15.
Deschacht, N., De Groeve K., Vincke C., Raes G., De Baetselier P., and Muyldermans S., "A novel promiscuous class of camelid single-domain antibody contributes to the antigen-binding repertoire.", J Immunol, vol. 184, issue 10, pp. 5696-704, 2010 May 15.
2009
Conrath, K., Pereira A. S., Martins C. E., Timóteo C. G., Tavares P., Spinelli S., Kinne J., Flaudrops C., Cambillau C., Muyldermans S., et al., "Camelid nanobodies raised against an integral membrane enzyme, nitric oxide reductase.", Protein Sci, vol. 18, issue 3, pp. 619-28, 2009 Mar.
Korotkov, K. V., Pardon E., Steyaert J., and Hol W. G. J., "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", Structure, vol. 17, issue 2, pp. 255-65, 2009 Feb 13.
Lam, A. Y., Pardon E., Korotkov K. V., Hol W. G. J., and Steyaert J., "Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus.", J Struct Biol, vol. 166, issue 1, pp. 8-15, 2009 Apr.
2008
Saerens, D., Conrath K., Govaert J., and Muyldermans S., "Disulfide bond introduction for general stabilization of immunoglobulin heavy-chain variable domains.", J Mol Biol, vol. 377, issue 2, pp. 478-88, 2008 Mar 21.
2007
Roovers, R. C., Laeremans T., Huang L., De Taeye S., Verkleij A. J., Revets H., de Haard H. J., and Henegouwen P. M. P. van Be, "Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-EFGR Nanobodies.", Cancer Immunol Immunother, vol. 56, issue 3, pp. 303-317, 2007 Mar.
2006
De Genst, E., Saerens D., Muyldermans S., and Conrath K., "Antibody repertoire development in camelids.", Dev Comp Immunol, vol. 30, issue 1-2, pp. 187-98, 2006.
Baral, T. Nath, Magez S., Stijlemans B., Conrath K., Vanhollebeke B., Pays E., Muyldermans S., and De Baetselier P., "Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor.", Nat Med, vol. 12, issue 5, pp. 580-4, 2006 May.
Brüggemann, M., Smith J. A., Osborn M. J., Corcos D., Zou X., Nguyen V. Khong, and Muyldermans S., "Heavy-chain-only antibody expression and B-cell development in the mouse.", Crit Rev Immunol, vol. 26, issue 5, pp. 377-90, 2006.
De Genst, E., Silence K., Decanniere K., Conrath K., Loris R., Kinne J., Muyldermans S., and Wyns L., "Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.", Proc Natl Acad Sci U S A, vol. 103, issue 12, pp. 4586-91, 2006 Mar 21.
Rothbauer, U., Zolghadr K., Tillib S., Nowak D., Schermelleh L., Gahl A., Backmann N., Conrath K., Muyldermans S., M Cardoso C., et al., "Targeting and tracing antigens in live cells with fluorescent nanobodies.", Nat Methods, vol. 3, issue 11, pp. 887-9, 2006 Nov.
2005
Zou, X., Smith J. A., Nguyen V. Khong, Ren L., Luyten K., Muyldermans S., and Brüggemann M., "Expression of a dromedary heavy chain-only antibody and B cell development in the mouse.", J Immunol, vol. 175, issue 6, pp. 3769-79, 2005 Sep 15.
Saerens, D., Pellis M., Loris R., Pardon E., Dumoulin M., Matagne A., Wyns L., Muyldermans S., and Conrath K., "Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies.", J Mol Biol, vol. 352, issue 3, pp. 597-607, 2005 Sep 23.
De Genst, E., Silence K., Ghahroudi M. Arbabi, Decanniere K., Loris R., Kinne J., Wyns L., and Muyldermans S., "Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires.", J Biol Chem, vol. 280, issue 14, pp. 14114-21, 2005 Apr 8.
2004
Saerens, D., Kinne J., Bosmans E., Wernery U., Muyldermans S., and Conrath K., "Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen.", J Biol Chem, vol. 279, issue 50, pp. 51965-72, 2004 Dec 10.

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