Publications

Found 195 results
Filters: Keyword is Protein Binding  [Clear All Filters]
2019
Talavera, A., H. Tamman, A. Ainelo, A. Konijnenberg, S. Hadži, F. Sobott, A. Garcia-Pino, R. Hõrak, and R. Loris, "A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT.", Nat Commun, vol. 10, issue 1, pp. 972, 2019 02 27.
Tsytlonok, M., H. Sanabria, Y. Wang, S. Felekyan, K. Hemmen, A. H. Phillips, M-K. Yun, B. M Waddell, C-G. Park, S. Vaithiyalingam, et al., "Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation.", Nat Commun, vol. 10, issue 1, pp. 1676, 2019 04 11.
Szabo, B., T. Horvath, E. Schad, N. Murvai, Á. Tantos, L. Kalmar, L. Beatriz Chemes, K-H. Han, and P. Tompa, "Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains.", Int J Mol Sci, vol. 20, issue 9, 2019 Apr 29.
2018
Pancsa, R., F. Zsolyomi, and P. Tompa, "Co-Evolution of Intrinsically Disordered Proteins with Folded Partners Witnessed by Evolutionary Couplings.", Int J Mol Sci, vol. 19, issue 11, 2018 Oct 25.
Henry, N., E-M. Krammer, F. Stengel, Q. Adams, F. Van Liefferinge, E. Hubin, R. Chaves, R. Efremov, R. Aebersold, G. Vandenbussche, et al., "Lipidated apolipoprotein E4 structure and its receptor binding mechanism determined by a combined cross-linking coupled to mass spectrometry and molecular dynamics approach.", PLoS Comput Biol, vol. 14, issue 6, pp. e1006165, 2018 06.
Talavera, A., J. Hendrix, W. Versées, D. Jurenas, K. Van Nerom, N. Vandenberk, R. Kumar Singh, A. Konijnenberg, S. De Gieter, D. Castro-Roa, et al., "Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.", Sci Adv, vol. 4, issue 3, pp. eaap9714, 2018 03.
Zavrtanik, U., J. Lukan, R. Loris, J. Lah, and S. Hadži, "Structural Basis of Epitope Recognition by Heavy-Chain Camelid Antibodies.", J Mol Biol, vol. 430, issue 21, pp. 4369-4386, 2018 10 19.
Lee, S., J. Choi, J. Mohanty, L. P. Sousa, F. Tome, E. Pardon, J. Steyaert, M. A. Lemmon, I. Lax, and J. Schlessinger, "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
2017
Nguyen, H. Huy, M. Varadi, P. Tompa, and K. Pauwels, "Affinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin.", PLoS One, vol. 12, issue 3, pp. e0174125, 2017.
Schacherl, M., M. Gompert, E. Pardon, T. Lamkemeyer, J. Steyaert, and U. Baumann, "Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.", Biochim Biophys Acta Biomembr, vol. 1859, issue 10, pp. 1859-1871, 2017 Oct.
Contreras-Martos, S., A. Piai, S. Kosol, M. Varadi, A. Bekesi, P. Lebrun, A. N. Volkov, K. Gevaert, R. Pierattelli, I. C. Felli, et al., "Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.", Sci Rep, vol. 7, issue 1, pp. 4676, 2017 07 05.
Vandervelde, A., I. Drobnak, S. Hadži, Y. G. - J. Sterckx, T. Welte, H. De Greve, D. Charlier, R. G. Efremov, R. Loris, and J. Lah, "Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.", Nucleic Acids Res, vol. 45, issue 6, pp. 2937-2950, 2017 Apr 07.
Manglik, A., B. K. Kobilka, and J. Steyaert, "Nanobodies to Study G Protein-Coupled Receptor Structure and Function.", Annu Rev Pharmacol Toxicol, vol. 57, pp. 19-37, 2017 01 06.
Talavera, A., H. Tamman, A. Ainelo, S. Hadǽi, A. Garcia-Pino, R. Hõrak, A. Konijnenberg, and R. Loris, "Production, biophysical characterization and crystallization of Pseudomonas putida GraA and its complexes with GraT and the graTA operator.", Acta Crystallogr F Struct Biol Commun, vol. 73, issue Pt 8, pp. 455-462, 2017 Aug 01.
Hadži, S., A. Garcia-Pino, S. Haesaerts, D. Jurenas, K. Gerdes, J. Lah, and R. Loris, "Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a β-strand sliding mechanism.", Nucleic Acids Res, vol. 45, issue 8, pp. 4972-4983, 2017 May 05.
Wohlkonig, A., H. Remaut, M. Moune, A. Tanina, F. Meyer, M. Desroses, J. Steyaert, N. Willand, A. R. Baulard, and R. Wintjens, "Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.", Biochem Biophys Res Commun, vol. 487, issue 2, pp. 403-408, 2017 05 27.
Miller, P. S., S. Scott, S. Masiulis, L. De Colibus, E. Pardon, J. Steyaert, and R. A Aricescu, "Structural basis for GABA receptor potentiation by neurosteroids.", Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
Hadži, S., A. Mernik, Č. Podlipnik, R. Loris, and J. Lah, "The Thermodynamic Basis of the Fuzzy Interaction of an Intrinsically Disordered Protein.", Angew Chem Int Ed Engl, vol. 56, issue 46, pp. 14494-14497, 2017 11 13.
2016
Devree, B. T., J. P. Mahoney, G. A. Vélez-Ruiz, S. G. F. Rasmussen, A. J. Kuszak, E. Edwald, J-J. Fung, A. Manglik, M. Masureel, Y. Du, et al., "Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.", Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
Antonik, P. M., A. N. Volkov, U. N. Broder, D. Lo Re, N. A. J. van Nuland, and P. B. Crowley, "Anomer-Specific Recognition and Dynamics in a Fucose-Binding Lectin.", Biochemistry, vol. 55, issue 8, pp. 1195-203, 2016 Mar 01.
Jiang, X., I. Smirnova, V. Kasho, J. Wu, K. Hirata, M. Ke, E. Pardon, J. Steyaert, N. Yan, and R. H Kaback, "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
Cho, K. Joon, B. Schepens, K. Moonens, L. Deng, W. Fiers, H. Remaut, and X. Saelens, "Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.", J Virol, vol. 90, issue 1, pp. 611-5, 2016 01 01.
Guharoy, M., P. Bhowmick, and P. Tompa, "Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.", J Biol Chem, vol. 291, issue 13, pp. 6723-31, 2016 Mar 25.
Peyrassol, X., T. Laeremans, M. Gouwy, V. Lahura, M. Debulpaep, J. Van Damme, J. Steyaert, M. Parmentier, and I. Langer, "Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.", J Immunol, vol. 196, issue 6, pp. 2893-901, 2016 Mar 15.
Egea-Jimenez, A. Luis, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. Maria Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau, and P. Zimmermann, "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.", Nat Commun, vol. 7, pp. 12101, 2016 07 08.

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