Publications

Found 30 results
Filters: Keyword is Protein Structure, Tertiary and Author is Wyns, Lode  [Clear All Filters]
2013
De Genst, E., P-H. Chan, E. Pardon, S-T. D. Hsu, J. R. Kumita, J. Christodoulou, L. Menzer, D. Y. Chirgadze, C. V. Robinson, S. Muyldermans, et al., "A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.", J Phys Chem B, vol. 117, issue 42, pp. 13245-58, 2013 Oct 24.
2011
Domanska, K., S. Vanderhaegen, V. Srinivasan, E. Pardon, F. Dupeux, J. A. Marquez, S. Giorgetti, M. Stoppini, L. Wyns, V. Bellotti, et al., "Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.", Proc Natl Acad Sci U S A, vol. 108, issue 4, pp. 1314-9, 2011 Jan 25.
2010
Garcia-Pino, A., S. Balasubramanian, L. Wyns, E. Gazit, H. De Greve, R. D. Magnuson, D. Charlier, N. A. J. van Nuland, and R. Loris, "Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.", Cell, vol. 142, issue 1, pp. 101-11, 2010 Jul 9.
2009
Garcia-Pino, A., S. Martinez-Rodriguez, K. Wahni, L. Wyns, R. Loris, and J. Messens, "Coupling of domain swapping to kinetic stability in a thioredoxin mutant.", J Mol Biol, vol. 385, issue 5, pp. 1590-9, 2009 Feb 6.
De Jonge, N., A. Garcia-Pino, L. Buts, S. Haesaerts, D. Charlier, K. Zangger, L. Wyns, H. De Greve, and R. Loris, "Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain.", Mol Cell, vol. 35, issue 2, pp. 154-63, 2009 Jul 31.
Respondek, M., L. Buts, N. De Jonge, S. Haesaerts, R. Loris, L. Van Melderen, L. Wyns, and K. Zangger, "Sequence-specific 1H, 15N and 13C resonance assignments of the 23.7-kDa homodimeric toxin CcdB from Vibrio fischeri.", Biomol NMR Assign, vol. 3, issue 1, pp. 145-7, 2009 Jun.
Van Molle, I., K. Moonens, A. Garcia-Pino, L. Buts, M. De Kerpel, L. Wyns, J. Bouckaert, and H. De Greve, "Structural and thermodynamic characterization of pre- and postpolymerization states in the F4 fimbrial subunit FaeG.", J Mol Biol, vol. 394, issue 5, pp. 957-67, 2009 Dec 18.
2008
Garcia-Pino, A., M. Christensen-Dalsgaard, L. Wyns, M. Yarmolinsky, R. David Magnuson, K. Gerdes, and R. Loris, "Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation.", J Biol Chem, vol. 283, issue 45, pp. 30821-7, 2008 Nov 7.
Tran, T., P. Büscher, G. Vandenbussche, L. Wyns, J. Messens, and H. De Greve, "Heterologous expression, purification and characterisation of the extracellular domain of trypanosome invariant surface glycoprotein ISG75.", J Biotechnol, vol. 135, issue 3, pp. 247-54, 2008 Jun 30.
Wellens, A., C. Garofalo, H. Nguyen, N. Van Gerven, R. Slättegård, J-P. Hernalsteens, L. Wyns, S. Oscarson, H. De Greve, S. Hultgren, et al., "Intervening with urinary tract infections using anti-adhesives based on the crystal structure of the FimH-oligomannose-3 complex.", PLoS One, vol. 3, issue 4, pp. e2040, 2008.
2007
Van Molle, I., J. J. Joensuu, L. Buts, S. Panjikar, M. Kotiaho, J. Bouckaert, L. Wyns, V. Niklander-Teeri, and H. De Greve, "Chloroplasts assemble the major subunit FaeG of Escherichia coli F4 (K88) fimbriae to strand-swapped dimers.", J Mol Biol, vol. 368, issue 3, pp. 791-9, 2007 May 4.
2006
De Genst, E., K. Silence, K. Decanniere, K. Conrath, R. Loris, J. Kinne, S. Muyldermans, and L. Wyns, "Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.", Proc Natl Acad Sci U S A, vol. 103, issue 12, pp. 4586-91, 2006 Mar 21.
2005
Conrath, K., C. Vincke, B. Stijlemans, J. Schymkowitz, K. Decanniere, L. Wyns, S. Muyldermans, and R. Loris, "Antigen binding and solubility effects upon the veneering of a camel VHH in framework-2 to mimic a VH.", J Mol Biol, vol. 350, issue 1, pp. 112-25, 2005 Jul 1.
Loris, R., A. Garcia-Pino, L. Buts, J. Bouckaert, S. Beeckmans, H. De Greve, and L. Wyns, "Crystallization and crystal manipulation of the Pterocarpus angolensis seed lectin.", Acta Crystallogr D Biol Crystallogr, vol. 61, issue Pt 6, pp. 685-9, 2005 Jun.
Buts, L., N. De Jonge, R. Loris, L. Wyns, and M-H. Dao-Thi, "Crystallization of the C-terminal domain of the addiction antidote CcdA in complex with its toxin CcdB.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 61, issue Pt 10, pp. 949-52, 2005 Oct 1.
Buts, L., A. Wellens, I. Van Molle, L. Wyns, R. Loris, M. Lahmann, S. Oscarson, H. De Greve, and J. Bouckaert, "Impact of natural variation in bacterial F17G adhesins on crystallization behaviour.", Acta Crystallogr D Biol Crystallogr, vol. 61, issue Pt 8, pp. 1149-59, 2005 Aug.
Dao-Thi, M-H., L. Van Melderen, E. De Genst, H. Afif, L. Buts, L. Wyns, and R. Loris, "Molecular basis of gyrase poisoning by the addiction toxin CcdB.", J Mol Biol, vol. 348, issue 5, pp. 1091-102, 2005 May 20.
Dumoulin, M., D. Canet, A. M. Last, E. Pardon, D. B. Archer, S. Muyldermans, L. Wyns, A. Matagne, C. V. Robinson, C. Redfield, et al., "Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.", J Mol Biol, vol. 346, issue 3, pp. 773-88, 2005 Feb 25.
De Genst, E., K. Silence, M. Arbabi Ghahroudi, K. Decanniere, R. Loris, J. Kinne, L. Wyns, and S. Muyldermans, "Strong in vivo maturation compensates for structurally restricted H3 loops in antibody repertoires.", J Biol Chem, vol. 280, issue 14, pp. 14114-21, 2005 Apr 8.
2004
De Genst, E., F. Handelberg, A. Van Meirhaeghe, S. Vynck, R. Loris, L. Wyns, and S. Muyldermans, "Chemical basis for the affinity maturation of a camel single domain antibody.", J Biol Chem, vol. 279, issue 51, pp. 53593-601, 2004 Dec 17.
Dao-Thi, M-H., L. Van Melderen, E. De Genst, L. Buts, A. Ranquin, L. Wyns, and R. Loris, "Crystallization of CcdB in complex with a GyrA fragment.", Acta Crystallogr D Biol Crystallogr, vol. 60, issue Pt 6, pp. 1132-4, 2004 Jun.
Stijlemans, B., K. Conrath, V. Cortez-Retamozo, H. Van Xong, L. Wyns, P. Senter, H. Revets, P. De Baetselier, S. Muyldermans, and S. Magez, "Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm.", J Biol Chem, vol. 279, issue 2, pp. 1256-61, 2004 Jan 9.
Messens, J., I. Van Molle, P. Vanhaesebrouck, K. Van Belle, K. Wahni, J. C. Martins, L. Wyns, and R. Loris, "The structure of a triple mutant of pI258 arsenate reductase from Staphylococcus aureus and its 5-thio-2-nitrobenzoic acid adduct.", Acta Crystallogr D Biol Crystallogr, vol. 60, issue Pt 6, pp. 1180-4, 2004 Jun.
2003
Dumoulin, M., A. M. Last, A. Desmyter, K. Decanniere, D. Canet, G. Larsson, A. Spencer, D. B. Archer, J. Sasse, S. Muyldermans, et al., "A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.", Nature, vol. 424, issue 6950, pp. 783-8, 2003 Aug 14.
Loris, R., I. Marianovsky, J. Lah, T. Laeremans, H. Engelberg-Kulka, G. Glaser, S. Muyldermans, and L. Wyns, "Crystal structure of the intrinsically flexible addiction antidote MazE.", J Biol Chem, vol. 278, issue 30, pp. 28252-7, 2003 Jul 25.

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