Publications
Found 17 results
Filters: Keyword is Trypanosoma vivax [Clear All Filters]
"Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax.",
Acta Crystallogr F Struct Biol Commun, vol. 71, issue Pt 5, pp. 577-85, 2015 May.
"Antibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor.",
Parasite Immunol, vol. 36, issue 6, pp. 271-6, 2014 Jun.
"A bacterial-two-hybrid selection system for one-step isolation of intracellularly functional Nanobodies.",
Arch Biochem Biophys, vol. 526, issue 2, pp. 114-23, 2012 Oct 15.
"Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.",
Biochim Biophys Acta, vol. 1794, issue 6, pp. 953-60, 2009 Jun.
"Substrate-dependent modulation of enzyme activity by allosteric effector antibodies.",
Biochim Biophys Acta, vol. 1794, issue 8, pp. 1259-68, 2009 Aug.
"A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax.",
J Biol Chem, vol. 283, issue 32, pp. 22272-82, 2008 Aug 08.
"N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase.",
Bioorg Med Chem, vol. 16, issue 14, pp. 6752-63, 2008 Jul 15.
"Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.",
Eur J Med Chem, vol. 43, issue 2, pp. 315-26, 2008 Feb.
"Examination of the mechanism and energetic contribution of leaving group activation in the purine-specific nucleoside hydrolase from Trypanosoma vivax.",
Biochim Biophys Acta, vol. 1774, issue 11, pp. 1451-61, 2007 Nov.
"Multiple transients in the pre-steady-state of nucleoside hydrolase reveal complex substrate binding, product base release, and two apparent rates of chemistry.",
Biochemistry, vol. 45, issue 30, pp. 9307-18, 2006 Aug 01.
"Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.",
J Mol Biol, vol. 359, issue 2, pp. 331-46, 2006 Jun 2.
"Substrate-assisted leaving group activation in enzyme-catalyzed N-glycosidic bond cleavage.",
J Biol Chem, vol. 280, issue 15, pp. 14799-802, 2005 Apr 15.
"Therapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system.",
Nano Lett, vol. 5, issue 11, pp. 2220-4, 2005 Nov.
"Leaving group activation by aromatic stacking: an alternative to general acid catalysis.",
J Mol Biol, vol. 338, issue 1, pp. 1-6, 2004 Apr 16.
"Pre-steady-state analysis of the nucleoside hydrolase of Trypanosoma vivax. Evidence for half-of-the-sites reactivity and rate-limiting product release.",
Biochemistry, vol. 42, issue 44, pp. 12902-8, 2003 Nov 11.
"Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.",
J Biol Chem, vol. 277, issue 18, pp. 15938-46, 2002 May 03.
"Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.",
J Mol Biol, vol. 307, issue 5, pp. 1363-79, 2001 Apr 13.