Publications
Found 60 results
Filters: Keyword is Models, Molecular and Author is Steyaert, Jan [Clear All Filters]
"Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.",
Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
"Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.",
Biochemistry, vol. 56, issue 30, pp. 3962-3971, 2017 08 01.
"Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.",
Biochimie, vol. 138, pp. 124-136, 2017 Jul.
"Structural basis for GABA receptor potentiation by neurosteroids.",
Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
"Structure of PINK1 in complex with its substrate ubiquitin.",
Nature, vol. 552, issue 7683, pp. 51-56, 2017 12 07.
"Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.",
Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
"Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.",
Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
"Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.",
Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
"Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.",
Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
"Propagation of conformational changes during μ-opioid receptor activation.",
Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
"Structural insights into µ-opioid receptor activation.",
Nature, vol. 524, issue 7565, pp. 315-21, 2015 Aug 20.
"Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.",
Nat Struct Mol Biol, vol. 22, issue 10, pp. 803-8, 2015 Oct.
"Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.",
RNA, vol. 20, issue 8, pp. 1257-71, 2014 Aug.
"Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.",
Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
"Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.",
Proc Natl Acad Sci U S A, vol. 111, issue 8, pp. 2984-9, 2014 Feb 25.
"A general protocol for the generation of Nanobodies for structural biology.",
Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
"Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.",
J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
"Activation and allosteric modulation of a muscarinic acetylcholine receptor.",
Nature, vol. 504, issue 7478, pp. 101-6, 2013 Dec 05.
"Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.",
Biochem J, vol. 450, issue 3, pp. 477-86, 2013 Mar 15.
"Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.",
Acta Crystallogr D Biol Crystallogr, vol. 69, issue Pt 6, pp. 1124-37, 2013 Jun.
"Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.",
Biochim Biophys Acta, vol. 1834, issue 10, pp. 2147-57, 2013 Oct.
"Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein.",
Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 3, pp. 270-4, 2013 Mar 1.
"Structure of a bacterial type IV secretion core complex at subnanometre resolution.",
EMBO J, vol. 32, issue 8, pp. 1195-204, 2013 Apr 17.
"Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis.",
Protein Sci, vol. 22, issue 10, pp. 1349-57, 2013 Oct.
"Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.",
Proc Natl Acad Sci U S A, vol. 110, issue 33, pp. 13386-91, 2013 Aug 13.