Publications

Found 159 results
Filters: Keyword is Binding Sites  [Clear All Filters]
2018
Singh, R. Kumar, A. Feller, M. Roovers, D. Van Elder, L. Wauters, L. Droogmans, and W. Versées, "Structural and biochemical analysis of the dual-specificity Trm10 enzyme from prompts reconsideration of its catalytic mechanism.", RNA, vol. 24, issue 8, pp. 1080-1092, 2018 08.
Lee, S., J. Choi, J. Mohanty, L. P. Sousa, F. Tome, E. Pardon, J. Steyaert, M. A. Lemmon, I. Lax, and J. Schlessinger, "Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.", Nature, vol. 553, issue 7689, pp. 501-505, 2018 01 25.
2017
Barros-Álvarez, X., K. M. Kerchner, C. Yeow Koh, S. Turley, E. Pardon, J. Steyaert, R. M. Ranade, R. J Gillespie, Z. Zhang, C. L. M. J. Verlinde, et al., "Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.", Biochimie, vol. 138, pp. 124-136, 2017 Jul.
Vandervelde, A., I. Drobnak, S. Hadži, Y. G. - J. Sterckx, T. Welte, H. De Greve, D. Charlier, R. G. Efremov, R. Loris, and J. Lah, "Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon.", Nucleic Acids Res, vol. 45, issue 6, pp. 2937-2950, 2017 Apr 07.
Wohlkonig, A., H. Remaut, M. Moune, A. Tanina, F. Meyer, M. Desroses, J. Steyaert, N. Willand, A. R. Baulard, and R. Wintjens, "Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.", Biochem Biophys Res Commun, vol. 487, issue 2, pp. 403-408, 2017 05 27.
Schubert, A. F., C. Gladkova, E. Pardon, J. L. Wagstaff, S. M. V. Freund, J. Steyaert, S. L. Maslen, and D. Komander, "Structure of PINK1 in complex with its substrate ubiquitin.", Nature, vol. 552, issue 7683, pp. 51-56, 2017 12 07.
2016
Jiang, X., I. Smirnova, V. Kasho, J. Wu, K. Hirata, M. Ke, E. Pardon, J. Steyaert, N. Yan, and R. H Kaback, "Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.", Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
Egea-Jimenez, A. Luis, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. Maria Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau, and P. Zimmermann, "Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.", Nat Commun, vol. 7, pp. 12101, 2016 07 08.
Fischer, B., K. Lüthy, J. Paesmans, C. De Koninck, I. Maes, J. Swerts, S. Kuenen, V. Uytterhoeven, P. Verstreken, and W. Versées, "Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.", Nat Struct Mol Biol, vol. 23, issue 11, pp. 965-973, 2016 Nov.
Moonens, K., P. Gideonsson, S. Subedi, J. Bugaytsova, E. Romão, M. Mendez, J. Nordén, M. Fallah, L. Rakhimova, A. Shevtsova, et al., "Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori.", Cell Host Microbe, vol. 19, issue 1, pp. 55-66, 2016 Jan 13.
Lafaye, C., I. Van Molle, V. Tamu Dufe, K. Wahni, A. Boudier, P. Leroy, J-F. Collet, and J. Messens, "Sulfur Denitrosylation by an Engineered Trx-like DsbG Enzyme Identifies Nucleophilic Cysteine Hydrogen Bonds as Key Functional Determinant.", J Biol Chem, vol. 291, issue 29, pp. 15020-8, 2016 07 15.
2015
Sounier, R., C. Mas, J. Steyaert, T. Laeremans, A. Manglik, W. Huang, B. K. Kobilka, H. Déméné, and S. Granier, "Propagation of conformational changes during μ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
Moonens, K., I. Van den Broeck, M. De Kerpel, F. Deboeck, H. Raymaekers, H. Remaut, and H. De Greve, "Structural and functional insight into the carbohydrate receptor binding of F4 fimbriae-producing enterotoxigenic Escherichia coli.", J Biol Chem, vol. 290, issue 13, pp. 8409-19, 2015 Mar 27.
Huang, W., A. Manglik, A. J. Venkatakrishnan, T. Laeremans, E. N. Feinberg, A. L. Sanborn, H. E. Kato, K. E. Livingston, T. S. Thorsen, R. C. Kling, et al., "Structural insights into µ-opioid receptor activation.", Nature, vol. 524, issue 7565, pp. 315-21, 2015 Aug 20.
2014
Van Laer, K., M. Oliveira, K. Wahni, and J. Messens, "The concerted action of a positive charge and hydrogen bonds dynamically regulates the pKa of the nucleophilic cysteine in the NrdH-redoxin family.", Protein Sci, vol. 23, issue 2, pp. 238-42, 2014 Feb.
Ehrnstorfer, I. A., E. R. Geertsma, E. Pardon, J. Steyaert, and R. Dutzler, "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.", Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
Meusch, D., C. Gatsogiannis, R. G. Efremov, A. E. Lang, O. Hofnagel, I. R. Vetter, K. Aktories, and S. Raunser, "Mechanism of Tc toxin action revealed in molecular detail.", Nature, vol. 508, issue 7494, pp. 61-5, 2014 Apr 03.
Tompa, P., N. E. Davey, T. J. Gibson, and M. M Babu, "A million peptide motifs for the molecular biologist.", Mol Cell, vol. 55, issue 2, pp. 161-9, 2014 Jul 17.
Lo, A. W. H., K. Moonens, M. De Kerpel, L. Brys, E. Pardon, H. Remaut, and H. De Greve, "The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.", J Biol Chem, vol. 289, issue 36, pp. 25374-81, 2014 Sep 05.
Zorzini, V., L. Buts, M. Sleutel, A. Garcia-Pino, A. Talavera, S. Haesaerts, H. De Greve, A. Cheung, N. A. J. van Nuland, and R. Loris, "Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics.", Nucleic Acids Res, vol. 42, issue 10, pp. 6709-25, 2014 Jun.
2013
Kruse, A. C., A. M. Ring, A. Manglik, J. Hu, K. Hu, K. Eitel, H. Hübner, E. Pardon, C. Valant, P. M. Sexton, et al., "Activation and allosteric modulation of a muscarinic acetylcholine receptor.", Nature, vol. 504, issue 7478, pp. 101-6, 2013 Dec 05.
Rocaboy, M., R. Herman, E. Sauvage, H. Remaut, K. Moonens, M. Terrak, P. Charlier, and F. Kerff, "The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain.", Mol Microbiol, vol. 90, issue 2, pp. 267-77, 2013 Oct.
Drobnak, I., N. De Jonge, S. Haesaerts, G. Vesnaver, R. Loris, and J. Lah, "Energetic basis of uncoupling folding from binding for an intrinsically disordered protein.", J Am Chem Soc, vol. 135, issue 4, pp. 1288-94, 2013 Jan 30.
Song, N., T. Nguyen Duc, L. van Oeffelen, S. Muyldermans, E. Peeters, and D. Charlier, "Expanded target and cofactor repertoire for the transcriptional activator LysM from Sulfolobus.", Nucleic Acids Res, vol. 41, issue 5, pp. 2932-49, 2013 Mar 1.
Gelens, L., L. Hill, A. Vandervelde, J. Danckaert, and R. Loris, "A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli.", PLoS Comput Biol, vol. 9, issue 8, pp. e1003190, 2013.

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