Publications
Found 43 results
Filters: Keyword is Protein Conformation and Author is Steyaert, Jan [Clear All Filters]
"Nanobodies to Study G Protein-Coupled Receptor Structure and Function.",
Annu Rev Pharmacol Toxicol, vol. 57, pp. 19-37, 2017 01 06.
"Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.",
Biochem Biophys Res Commun, vol. 487, issue 2, pp. 403-408, 2017 05 27.
"Structural basis for GABA receptor potentiation by neurosteroids.",
Nat Struct Mol Biol, vol. 24, issue 11, pp. 986-992, 2017 Nov.
"Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.",
Nature, vol. 535, issue 7610, pp. 182-6, 2016 Jul 07.
"Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.",
Nature, vol. 535, issue 7612, pp. 448-52, 2016 Jul 21.
"Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation.",
Proc Natl Acad Sci U S A, vol. 113, issue 44, pp. 12420-12425, 2016 11 01.
"Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.",
Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
"Propagation of conformational changes during μ-opioid receptor activation.",
Nature, vol. 524, issue 7565, pp. 375-8, 2015 Aug 20.
"Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.",
Nat Struct Mol Biol, vol. 22, issue 10, pp. 803-8, 2015 Oct.
"Transient conformers of LacY are trapped by nanobodies.",
Proc Natl Acad Sci U S A, vol. 112, issue 45, pp. 13839-44, 2015 Nov 10.
"Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.",
RNA, vol. 20, issue 8, pp. 1257-71, 2014 Aug.
"Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.",
Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
"Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.",
Proc Natl Acad Sci U S A, vol. 111, issue 8, pp. 2984-9, 2014 Feb 25.
"A general protocol for the generation of Nanobodies for structural biology.",
Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
"Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.",
Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
"Conformational biosensors reveal GPCR signalling from endosomes.",
Nature, vol. 495, issue 7442, pp. 534-8, 2013 Mar 28.
"Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.",
PLoS One, vol. 8, issue 4, pp. e60259, 2013.
"Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.",
Acta Crystallogr D Biol Crystallogr, vol. 69, issue Pt 6, pp. 1124-37, 2013 Jun.
"Structure of a bacterial type IV secretion core complex at subnanometre resolution.",
EMBO J, vol. 32, issue 8, pp. 1195-204, 2013 Apr 17.
"Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.",
Proc Natl Acad Sci U S A, vol. 110, issue 33, pp. 13386-91, 2013 Aug 13.
"Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.",
J Mol Biol, vol. 407, issue 1, pp. 138-48, 2011 Mar 18.
"Nanobody stabilization of G protein-coupled receptor conformational states.",
Curr Opin Struct Biol, vol. 21, issue 4, pp. 567-72, 2011 Aug.
"Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.",
Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.
"Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.",
Nature, vol. 469, issue 7329, pp. 175-80, 2011 Jan 13.
"Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.",
Biochim Biophys Acta, vol. 1794, issue 6, pp. 953-60, 2009 Jun.