Publications

Found 73 results
Filters: Author is Pardon, Els  [Clear All Filters]
2015
Newman, J. A., P. Savitsky, C. K. Allerston, A. H. Bizard, Ö. Özer, K. Sarlós, Y. Liu, E. Pardon, J. Steyaert, I. D. Hickson, et al., "Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.", Nucleic Acids Res, vol. 43, issue 10, pp. 5221-35, 2015 May 26.
Moonens, K., I. Van den Broeck, E. Okello, E. Pardon, M. De Kerpel, H. Remaut, and H. De Greve, "Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies.", Vet Res, vol. 46, pp. 14, 2015 Feb 24.
Rostislavleva, K., N. Soler, Y. Ohashi, L. Zhang, E. Pardon, J. E. Burke, G. R. Masson, C. Johnson, J. Steyaert, N. T. Ktistakis, et al., "Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.", Science, vol. 350, issue 6257, pp. aac7365, 2015 Oct 09.
Geertsma, E. R., Y-N. Chang, F. R. Shaik, Y. Neldner, E. Pardon, J. Steyaert, and R. Dutzler, "Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family.", Nat Struct Mol Biol, vol. 22, issue 10, pp. 803-8, 2015 Oct.
Smirnova, I., V. Kasho, X. Jiang, E. Pardon, J. Steyaert, and R. H Kaback, "Transient conformers of LacY are trapped by nanobodies.", Proc Natl Acad Sci U S A, vol. 112, issue 45, pp. 13839-44, 2015 Nov 10.
2014
Ehrnstorfer, I. A., E. R. Geertsma, E. Pardon, J. Steyaert, and R. Dutzler, "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport.", Nat Struct Mol Biol, vol. 21, issue 11, pp. 990-6, 2014 Nov.
Pathare, G. Ramnath, I. Nagy, P. Śledź, D. J. Anderson, H-J. Zhou, E. Pardon, J. Steyaert, F. Förster, A. Bracher, and W. Baumeister, "Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11.", Proc Natl Acad Sci U S A, vol. 111, issue 8, pp. 2984-9, 2014 Feb 25.
Pardon, E., T. Laeremans, S. Triest, S. G. F. Rasmussen, A. Wohlkonig, A. Ruf, S. Muyldermans, W. G. J. Hol, B. K. Kobilka, and J. Steyaert, "A general protocol for the generation of Nanobodies for structural biology.", Nat Protoc, vol. 9, issue 3, pp. 674-93, 2014 Mar.
Nunes-Silva, S., S. Gangnard, M. Vidal, A. Vuchelen, S. Dechavanne, S. Chan, E. Pardon, J. Steyaert, S. Ramboarina, A. Chêne, et al., "Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.", Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
Lo, A. W. H., K. Moonens, M. De Kerpel, L. Brys, E. Pardon, H. Remaut, and H. De Greve, "The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain.", J Biol Chem, vol. 289, issue 36, pp. 25374-81, 2014 Sep 05.
Moonens, K., M. De Kerpel, A. Coddens, E. Cox, E. Pardon, H. Remaut, and H. De Greve, "Nanobody mediated inhibition of attachment of F18 Fimbriae expressing Escherichia coli.", PLoS One, vol. 9, issue 12, pp. e114691, 2014.
Smirnova, I., V. Kasho, X. Jiang, E. Pardon, J. Steyaert, and R. H Kaback, "Outward-facing conformers of LacY stabilized by nanobodies.", Proc Natl Acad Sci U S A, vol. 111, issue 52, pp. 18548-53, 2014 Dec 30.
Abskharon, R. N. N., G. Giachin, A. Wohlkonig, S. H. Soror, E. Pardon, G. Legname, and J. Steyaert, "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
Triest, S., A. Wohlkonig, E. Pardon, and J. Steyaert, "Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 11, pp. 1504-7, 2014 Nov.
Staus, D. P., L. M. Wingler, R. T. Strachan, S. G. F. Rasmussen, E. Pardon, S. Ahn, J. Steyaert, B. K. Kobilka, and R. J. Lefkowitz, "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.
Fislage, M., E. Brosens, E. Deyaert, A. Spilotros, E. Pardon, R. Loris, J. Steyaert, A. Garcia-Pino, and W. Versées, "SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization.", Nucleic Acids Res, vol. 42, issue 9, pp. 5978-92, 2014 May.
2013
Kruse, A. C., A. M. Ring, A. Manglik, J. Hu, K. Hu, K. Eitel, H. Hübner, E. Pardon, C. Valant, P. M. Sexton, et al., "Activation and allosteric modulation of a muscarinic acetylcholine receptor.", Nature, vol. 504, issue 7478, pp. 101-6, 2013 Dec 05.
Sohier, J. S., C. Laurent, A. Chevigné, E. Pardon, V. Srinivasan, U. Wernery, P. Lassaux, J. Steyaert, and M. Galleni, "Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.", Biochem J, vol. 450, issue 3, pp. 477-86, 2013 Mar 15.
Guilliams, T., F. El-Turk, A. K. Buell, E. M. O'Day, F. A. Aprile, E. K. Esbjörner, M. Vendruscolo, N. Cremades, E. Pardon, L. Wyns, et al., "Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.", J Mol Biol, vol. 425, issue 14, pp. 2397-411, 2013 Jul 24.
De Genst, E., P-H. Chan, E. Pardon, S-T. D. Hsu, J. R. Kumita, J. Christodoulou, L. Menzer, D. Y. Chirgadze, C. V. Robinson, S. Muyldermans, et al., "A nanobody binding to non-amyloidogenic regions of the protein human lysozyme enhances partial unfolding but inhibits amyloid fibril formation.", J Phys Chem B, vol. 117, issue 42, pp. 13245-58, 2013 Oct 24.
Löw, C., Y. Hoe Yau, E. Pardon, C. Jegerschöld, L. Wåhlin, E. M. Quistgaard, P. Moberg, S. Geifman-Shochat, J. Steyaert, and P. Nordlund, "Nanobody mediated crystallization of an archeal mechanosensitive channel.", PLoS One, vol. 8, issue 10, pp. e77984, 2013.
Vuchelen, A., E. Pardon, J. Steyaert, B. Gamain, R. Loris, N. A. J. van Nuland, and S. Ramboarina, "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein. Corrigendum.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 11, pp. 1312, 2013 Nov.
Vuchelen, A., E. Pardon, J. Steyaert, B. Gamain, R. Loris, N. A. J. van Nuland, and S. Ramboarina, "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 3, pp. 270-4, 2013 Mar 1.
Rivera-Calzada, A., R. Fronzes, C. G. Savva, V. Chandran, P. W. Lian, T. Laeremans, E. Pardon, J. Steyaert, H. Remaut, G. Waksman, et al., "Structure of a bacterial type IV secretion core complex at subnanometre resolution.", EMBO J, vol. 32, issue 8, pp. 1195-204, 2013 Apr 17.
Vanderhaegen, S., M. Fislage, K. Domanska, W. Versées, E. Pardon, V. Bellotti, and J. Steyaert, "Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis.", Protein Sci, vol. 22, issue 10, pp. 1349-57, 2013 Oct.

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