Publications
Found 48 results
Filters: Keyword is Models, Molecular and Author is Jan Steyaert [Clear All Filters]
"The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2.",
Nucleic Acids Res, vol. 40, issue 14, pp. 6966-77, 2012 Aug.
"Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.",
Proc Natl Acad Sci U S A, vol. 108, issue 4, pp. 1314-9, 2011 Jan 25.
"Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.",
J Mol Biol, vol. 407, issue 1, pp. 138-48, 2011 Mar 18.
"Crystal structure of the β2 adrenergic receptor-Gs protein complex.",
Nature, vol. 477, issue 7366, pp. 549-55, 2011 Sep 29.
"Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.",
Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.
"Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.",
Nature, vol. 469, issue 7329, pp. 175-80, 2011 Jan 13.
"A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction.",
Cell Mol Life Sci, vol. 67, issue 9, pp. 1519-35, 2010 May.
"Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.",
J Mol Biol, vol. 402, issue 2, pp. 326-43, 2010 Sep 17.
"Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.",
Structure, vol. 17, issue 2, pp. 255-65, 2009 Feb 13.
"Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus.",
J Struct Biol, vol. 166, issue 1, pp. 8-15, 2009 Apr.
"Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.",
Eur J Med Chem, vol. 43, issue 2, pp. 315-26, 2008 Feb.
"Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.",
J Mol Biol, vol. 359, issue 2, pp. 331-46, 2006 Jun 2.
"A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study.",
J Biol Chem, vol. 277, issue 39, pp. 36770-4, 2002 Sep 27.
"Hydrophobic core manipulations in ribonuclease T1.",
Biochemistry, vol. 40, issue 34, pp. 10140-9, 2001 Aug 28.
"Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.",
J Mol Biol, vol. 307, issue 5, pp. 1363-79, 2001 Apr 13.
"Analysis of a water mediated protein-protein interactions within RNase T1.",
Biochemistry, vol. 39, issue 22, pp. 6586-93, 2000 Jun 6.
"Mechanism of RNase T1: concerted triester-like phosphoryl transfer via a catalytic three-centered hydrogen bond.",
Chem Biol, vol. 7, issue 8, pp. 651-8, 2000 Aug.
"Conserved water molecules in a large family of microbial ribonucleases.",
Proteins, vol. 36, issue 1, pp. 117-34, 1999 Jul 1.
"Dissection of the structural and functional role of a conserved hydration site in RNase T1.",
Protein Sci, vol. 8, issue 4, pp. 722-30, 1999 Apr.
"Dissecting histidine interactions of ribonuclease T1 with asparagine and glutamine replacements: analysis of double mutant cycles at one position.",
J Mol Biol, vol. 275, issue 4, pp. 651-61, 1998 Jan 30.
"An engineered ribonuclease preferring phosphorothioate RNA.",
Nat Struct Biol, vol. 5, issue 5, pp. 365-8, 1998 May.
"Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallography.",
Nat Struct Biol, vol. 5, issue 4, pp. 280-3, 1998 Apr.
"Additivity of protein-guanine interactions in ribonuclease T1.",
J Biol Chem, vol. 272, issue 15, pp. 9635-9, 1997 Apr 11.