Publications

Found 155 results
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2014
Oyen, D., J. Steyaert, and J. N. Barlow, "Inhibition of ligand exchange kinetics via active-site trapping with an antibody fragment.", Biochemistry, vol. 53, issue 12, pp. 1879-81, 2014 Apr 01.
Nunes-Silva, S., S. Gangnard, M. Vidal, A. Vuchelen, S. Dechavanne, S. Chan, E. Pardon, J. Steyaert, S. Ramboarina, A. Chêne, et al., "Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain.", Sci Rep, vol. 4, pp. 7373, 2014 Dec 09.
Smirnova, I., V. Kasho, X. Jiang, E. Pardon, J. Steyaert, and R. H Kaback, "Outward-facing conformers of LacY stabilized by nanobodies.", Proc Natl Acad Sci U S A, vol. 111, issue 52, pp. 18548-53, 2014 Dec 30.
Abskharon, R. N. N., G. Giachin, A. Wohlkonig, S. H. Soror, E. Pardon, G. Legname, and J. Steyaert, "Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.", J Am Chem Soc, vol. 136, issue 3, pp. 937-44, 2014 Jan 22.
Triest, S., A. Wohlkonig, E. Pardon, and J. Steyaert, "Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody.", Acta Crystallogr F Struct Biol Commun, vol. 70, issue Pt 11, pp. 1504-7, 2014 Nov.
Staus, D. P., L. M. Wingler, R. T. Strachan, S. G. F. Rasmussen, E. Pardon, S. Ahn, J. Steyaert, B. K. Kobilka, and R. J. Lefkowitz, "Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.", Mol Pharmacol, vol. 85, issue 3, pp. 472-81, 2014 Mar.
Fislage, M., E. Brosens, E. Deyaert, A. Spilotros, E. Pardon, R. Loris, J. Steyaert, A. Garcia-Pino, and W. Versées, "SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization.", Nucleic Acids Res, vol. 42, issue 9, pp. 5978-92, 2014 May.
2013
Kruse, A. C., A. M. Ring, A. Manglik, J. Hu, K. Hu, K. Eitel, H. Hübner, E. Pardon, C. Valant, P. M. Sexton, et al., "Activation and allosteric modulation of a muscarinic acetylcholine receptor.", Nature, vol. 504, issue 7478, pp. 101-6, 2013 Dec 05.
Sohier, J. S., C. Laurent, A. Chevigné, E. Pardon, V. Srinivasan, U. Wernery, P. Lassaux, J. Steyaert, and M. Galleni, "Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody.", Biochem J, vol. 450, issue 3, pp. 477-86, 2013 Mar 15.
Irannejad, R., J. C. Tomshine, J. R. Tomshine, M. Chevalier, J. P. Mahoney, J. Steyaert, S. G. F. Rasmussen, R. K. Sunahara, H. El-Samad, B. Huang, et al., "Conformational biosensors reveal GPCR signalling from endosomes.", Nature, vol. 495, issue 7442, pp. 534-8, 2013 Mar 28.
Vercruysse, T., E. Boons, T. Venken, E. Vanstreels, A. Voet, J. Steyaert, M. De Maeyer, and D. Daelemans, "Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein Rev.", PLoS One, vol. 8, issue 4, pp. e60259, 2013.
Banner, D. W., B. Gsell, J. Benz, J. Bertschinger, D. Burger, S. Brack, S. Cuppuleri, M. Debulpaep, A. Gast, D. Grabulovski, et al., "Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.", Acta Crystallogr D Biol Crystallogr, vol. 69, issue Pt 6, pp. 1124-37, 2013 Jun.
Oyen, D., R. Wechselberger, V. Srinivasan, J. Steyaert, and J. N. Barlow, "Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihydrofolate reductase of Escherichia coli.", Biochim Biophys Acta, vol. 1834, issue 10, pp. 2147-57, 2013 Oct.
Guilliams, T., F. El-Turk, A. K. Buell, E. M. O'Day, F. A. Aprile, E. K. Esbjörner, M. Vendruscolo, N. Cremades, E. Pardon, L. Wyns, et al., "Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages.", J Mol Biol, vol. 425, issue 14, pp. 2397-411, 2013 Jul 24.
Löw, C., Y. Hoe Yau, E. Pardon, C. Jegerschöld, L. Wåhlin, E. M. Quistgaard, P. Moberg, S. Geifman-Shochat, J. Steyaert, and P. Nordlund, "Nanobody mediated crystallization of an archeal mechanosensitive channel.", PLoS One, vol. 8, issue 10, pp. e77984, 2013.
Vuchelen, A., E. Pardon, J. Steyaert, B. Gamain, R. Loris, N. A. J. van Nuland, and S. Ramboarina, "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein. Corrigendum.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 11, pp. 1312, 2013 Nov.
Vuchelen, A., E. Pardon, J. Steyaert, B. Gamain, R. Loris, N. A. J. van Nuland, and S. Ramboarina, "Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 69, issue Pt 3, pp. 270-4, 2013 Mar 1.
Yuan, J., Y-A. Zhan, R. Abskharon, X. Xiao, M. Camacho Martinez, X. Zhou, G. Kneale, J. Mikol, S. Lehmann, W. K. Surewicz, et al., "Recombinant human prion protein inhibits prion propagation in vitro.", Sci Rep, vol. 3, pp. 2911, 2013.
Rivera-Calzada, A., R. Fronzes, C. G. Savva, V. Chandran, P. W. Lian, T. Laeremans, E. Pardon, J. Steyaert, H. Remaut, G. Waksman, et al., "Structure of a bacterial type IV secretion core complex at subnanometre resolution.", EMBO J, vol. 32, issue 8, pp. 1195-204, 2013 Apr 17.
Vanderhaegen, S., M. Fislage, K. Domanska, W. Versées, E. Pardon, V. Bellotti, and J. Steyaert, "Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis.", Protein Sci, vol. 22, issue 10, pp. 1349-57, 2013 Oct.
Khamrui, S., S. Turley, E. Pardon, J. Steyaert, E. Fan, C. L. M. J. Verlinde, L. W. Bergman, and W. G. J. Hol, "The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.", Mol Biochem Parasitol, vol. 190, issue 2, pp. 87-91, 2013 Aug.
Ward, A. B., P. Szewczyk, V. Grimard, C-W. Lee, L. Martinez, R. Doshi, A. Caya, M. Villaluz, E. Pardon, C. Cregger, et al., "Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.", Proc Natl Acad Sci U S A, vol. 110, issue 33, pp. 13386-91, 2013 Aug 13.
2012
Park, Y-J., E. Pardon, M. Wu, J. Steyaert, and W. G. J. Hol, "Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody.", Nucleic Acids Res, vol. 40, issue 4, pp. 1828-40, 2012 Feb.
Abskharon, R. N. N., S. Ramboarina, H. El Hassan, W. Gad, M. I. Apostol, G. Giachin, G. Legname, J. Steyaert, J. Messens, S. H. Soror, et al., "A novel expression system for production of soluble prion proteins in E. coli.", Microb Cell Fact, vol. 11, pp. 6, 2012 Jan 10.
Baranova, E., R. Fronzes, A. Garcia-Pino, N. Van Gerven, D. Papapostolou, G. Péhau-Arnaudet, E. Pardon, J. Steyaert, S. Howorka, and H. Remaut, "SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly.", Nature, vol. 487, issue 7405, pp. 119-22, 2012 Jul 5.

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