Publications

Found 155 results
Filters: Author is Jan Steyaert  [Clear All Filters]
2011
Domanska, K., S. Vanderhaegen, V. Srinivasan, E. Pardon, F. Dupeux, J. A. Marquez, S. Giorgetti, M. Stoppini, L. Wyns, V. Bellotti, et al., "Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant.", Proc Natl Acad Sci U S A, vol. 108, issue 4, pp. 1314-9, 2011 Jan 25.
Abskharon, R. N. N., S. H. Soror, E. Pardon, H. El Hassan, G. Legname, J. Steyaert, and A. Wohlkonig, "Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes.", Protein Eng Des Sel, vol. 24, issue 9, pp. 737-41, 2011 Sep.
Oyen, D., V. Srinivasan, J. Steyaert, and J. N. Barlow, "Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.", J Mol Biol, vol. 407, issue 1, pp. 138-48, 2011 Mar 18.
Rasmussen, S. G. F., B. T. Devree, Y. Zou, A. C. Kruse, K. Young Chung, T. Sun Kobilka, F. Sun Thian, P. Seok Chae, E. Pardon, D. Calinski, et al., "Crystal structure of the β2 adrenergic receptor-Gs protein complex.", Nature, vol. 477, issue 7366, pp. 549-55, 2011 Sep 29.
Vercruysse, T., S. Pawar, W. De Borggraeve, E. Pardon, G. N. Pavlakis, C. Pannecouque, J. Steyaert, J. Balzarini, and D. Daelemans, "Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer.", RNA Biol, vol. 8, issue 2, pp. 316-24, 2011 Mar-Apr.
Steyaert, J., and B. K. Kobilka, "Nanobody stabilization of G protein-coupled receptor conformational states.", Curr Opin Struct Biol, vol. 21, issue 4, pp. 567-72, 2011 Aug.
Korotkov, K. V., T. L. Johnson, M. G. Jobling, J. Pruneda, E. Pardon, A. Héroux, S. Turley, J. Steyaert, R. K. Holmes, M. Sandkvist, et al., "Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.", PLoS Pathog, vol. 7, issue 9, pp. e1002228, 2011 Sep.
Westfield, G. H., S. G. F. Rasmussen, M. Su, S. Dutta, B. T. Devree, K. Young Chung, D. Calinski, G. Velez-Ruiz, A. N. Oleskie, E. Pardon, et al., "Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.", Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.
Rasmussen, S. G. F., H-J. Choi, J. Jose Fung, E. Pardon, P. Casarosa, P. Seok Chae, B. T. Devree, D. M. Rosenbaum, F. Sun Thian, T. Sun Kobilka, et al., "Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.", Nature, vol. 469, issue 7329, pp. 175-80, 2011 Jan 13.
Wu, M., Y-J. Park, E. Pardon, S. Turley, A. Hayhurst, J. Deng, J. Steyaert, and W. G. J. Hol, "Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.", J Struct Biol, vol. 174, issue 1, pp. 124-36, 2011 Apr.
2010
Abskharon, R. N. N., S. H. Soror, E. Pardon, H. El Hassan, G. Legname, J. Steyaert, and A. Wohlkonig, "Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 66, issue Pt 12, pp. 1644-6, 2010 Dec 1.
Berg, M., L. Kohl, P. Van der Veken, J. Joossens, M. I. Al-Salabi, V. Castagna, F. Giannese, P. Cos, W. Versées, J. Steyaert, et al., "Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.", Antimicrob Agents Chemother, vol. 54, issue 5, pp. 1900-8, 2010 May.
Vercruysse, T., E. Pardon, E. Vanstreels, J. Steyaert, and D. Daelemans, "An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.", J Biol Chem, vol. 285, issue 28, pp. 21768-80, 2010 Jul 9.
Ryckaert, S., E. Pardon, J. Steyaert, and N. Callewaert, "Isolation of antigen-binding camelid heavy chain antibody fragments (nanobodies) from an immune library displayed on the surface of Pichia pastoris.", J Biotechnol, vol. 145, issue 2, pp. 93-8, 2010 Jan 15.
Van den Abbeele, A., S. De Clercq, A. De Ganck, V. De Corte, B. Van Loo, S. Hamdy Soror, V. Srinivasan, J. Steyaert, J. Vandekerckhove, and J. Gettemans, "A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction.", Cell Mol Life Sci, vol. 67, issue 9, pp. 1519-35, 2010 May.
De Vocht, C., A. Ranquin, J. Van Ginderachter, T. Vanhaecke, V. Rogiers, P. Van Gelder, W. Versées, and J. Steyaert, "Polymeric nanoreactors for enzyme replacement therapy of MNGIE.", J Control Release, vol. 148, issue 1, pp. e19-20, 2010 Nov 20.
Vandemeulebroucke, A., C. Minici, I. Bruno, L. Muzzolini, P. Tornaghi, D. W. Parkin, W. Versées, J. Steyaert, and M. Degano, "Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei.", Biochemistry, vol. 49, issue 41, pp. 8999-9010, 2010 Oct 19.
De Genst, E., T. Guilliams, J. Wellens, E. M. O'Day, C. A. Waudby, S. Meehan, M. Dumoulin, S-T. D. Hsu, N. Cremades, K. H. G. Verschueren, et al., "Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.", J Mol Biol, vol. 402, issue 2, pp. 326-43, 2010 Sep 17.
2009
De Vocht, C., A. Ranquin, R. Willaert, J. A. Van Ginderachter, T. Vanhaecke, V. Rogiers, W. Versées, P. Van Gelder, and J. Steyaert, "Assessment of stability, toxicity and immunogenicity of new polymeric nanoreactors for use in enzyme replacement therapy of MNGIE.", J Control Release, vol. 137, issue 3, pp. 246-54, 2009 Aug 4.
Korotkov, K. V., E. Pardon, J. Steyaert, and W. G. J. Hol, "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", Structure, vol. 17, issue 2, pp. 255-65, 2009 Feb 13.
Versées, W., A. Goeminne, M. Berg, A. Vandemeulebroucke, A. Haemers, K. Augustyns, and J. Steyaert, "Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.", Biochim Biophys Acta, vol. 1794, issue 6, pp. 953-60, 2009 Jun.
Lam, A. Y., E. Pardon, K. V. Korotkov, W. G. J. Hol, and J. Steyaert, "Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus.", J Struct Biol, vol. 166, issue 1, pp. 8-15, 2009 Apr.
Barlow, J. N., K. Conrath, and J. Steyaert, "Substrate-dependent modulation of enzyme activity by allosteric effector antibodies.", Biochim Biophys Acta, vol. 1794, issue 8, pp. 1259-68, 2009 Aug.
Berg, M., G. Bal, A. Goeminne, P. Van der Veken, W. Versées, J. Steyaert, A. Haemers, and K. Augustyns, "Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors.", ChemMedChem, vol. 4, issue 2, pp. 249-60, 2009 Feb.

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