Publications

Found 131 results
Filters: Author is Jan Steyaert  [Clear All Filters]
2011
Rasmussen, S. G. F., B. T. Devree, Y. Zou, A. C. Kruse, K. Young Chung, T. Sun Kobilka, F. Sun Thian, P. Seok Chae, E. Pardon, D. Calinski, et al., "Crystal structure of the β2 adrenergic receptor-Gs protein complex.", Nature, vol. 477, issue 7366, pp. 549-55, 2011 Sep 29.
Vercruysse, T., S. Pawar, W. De Borggraeve, E. Pardon, G. N. Pavlakis, C. Pannecouque, J. Steyaert, J. Balzarini, and D. Daelemans, "Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer.", RNA Biol, vol. 8, issue 2, pp. 316-24, 2011 Mar-Apr.
Steyaert, J., and B. K. Kobilka, "Nanobody stabilization of G protein-coupled receptor conformational states.", Curr Opin Struct Biol, vol. 21, issue 4, pp. 567-72, 2011 Aug.
Korotkov, K. V., T. L. Johnson, M. G. Jobling, J. Pruneda, E. Pardon, A. Héroux, S. Turley, J. Steyaert, R. K. Holmes, M. Sandkvist, et al., "Structural and functional studies on the interaction of GspC and GspD in the type II secretion system.", PLoS Pathog, vol. 7, issue 9, pp. e1002228, 2011 Sep.
Westfield, G. H., S. G. F. Rasmussen, M. Su, S. Dutta, B. T. Devree, K. Young Chung, D. Calinski, G. Velez-Ruiz, A. N. Oleskie, E. Pardon, et al., "Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.", Proc Natl Acad Sci U S A, vol. 108, issue 38, pp. 16086-91, 2011 Sep 20.
Rasmussen, S. G. F., H-J. Choi, J. Jose Fung, E. Pardon, P. Casarosa, P. Seok Chae, B. T. Devree, D. M. Rosenbaum, F. Sun Thian, T. Sun Kobilka, et al., "Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.", Nature, vol. 469, issue 7329, pp. 175-80, 2011 Jan 13.
Wu, M., Y-J. Park, E. Pardon, S. Turley, A. Hayhurst, J. Deng, J. Steyaert, and W. G. J. Hol, "Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.", J Struct Biol, vol. 174, issue 1, pp. 124-36, 2011 Apr.
2010
Abskharon, R. N. N., S. H. Soror, E. Pardon, H. El Hassan, G. Legname, J. Steyaert, and A. Wohlkonig, "Crystallization and preliminary X-ray diffraction analysis of a specific VHH domain against mouse prion protein.", Acta Crystallogr Sect F Struct Biol Cryst Commun, vol. 66, issue Pt 12, pp. 1644-6, 2010 Dec 1.
Vercruysse, T., E. Pardon, E. Vanstreels, J. Steyaert, and D. Daelemans, "An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.", J Biol Chem, vol. 285, issue 28, pp. 21768-80, 2010 Jul 9.
Ryckaert, S., E. Pardon, J. Steyaert, and N. Callewaert, "Isolation of antigen-binding camelid heavy chain antibody fragments (nanobodies) from an immune library displayed on the surface of Pichia pastoris.", J Biotechnol, vol. 145, issue 2, pp. 93-8, 2010 Jan 15.
Van den Abbeele, A., S. De Clercq, A. De Ganck, V. De Corte, B. Van Loo, S. Hamdy Soror, V. Srinivasan, J. Steyaert, J. Vandekerckhove, and J. Gettemans, "A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction.", Cell Mol Life Sci, vol. 67, issue 9, pp. 1519-35, 2010 May.
De Genst, E., T. Guilliams, J. Wellens, E. M. O'Day, C. A. Waudby, S. Meehan, M. Dumoulin, S-T. D. Hsu, N. Cremades, K. H. G. Verschueren, et al., "Structure and properties of a complex of α-synuclein and a single-domain camelid antibody.", J Mol Biol, vol. 402, issue 2, pp. 326-43, 2010 Sep 17.
2009
Korotkov, K. V., E. Pardon, J. Steyaert, and W. G. J. Hol, "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", Structure, vol. 17, issue 2, pp. 255-65, 2009 Feb 13.
Lam, A. Y., E. Pardon, K. V. Korotkov, W. G. J. Hol, and J. Steyaert, "Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus.", J Struct Biol, vol. 166, issue 1, pp. 8-15, 2009 Apr.
Barlow, J. N., K. Conrath, and J. Steyaert, "Substrate-dependent modulation of enzyme activity by allosteric effector antibodies.", Biochim Biophys Acta, vol. 1794, issue 8, pp. 1259-68, 2009 Aug.
2008
Goeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, and K. Augustyns, "Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.", Eur J Med Chem, vol. 43, issue 2, pp. 315-26, 2008 Feb.
2007
Goeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, S. Apers, A. Haemers, et al., "1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.", Bioorg Med Chem Lett, vol. 17, issue 9, pp. 2523-6, 2007 May 1.
Barlow, J. N., and J. Steyaert, "Examination of the mechanism and energetic contribution of leaving group activation in the purine-specific nucleoside hydrolase from Trypanosoma vivax.", Biochim Biophys Acta, vol. 1774, issue 11, pp. 1451-61, 2007 Nov.
2006
Versées, W., J. Barlow, and J. Steyaert, "Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.", J Mol Biol, vol. 359, issue 2, pp. 331-46, 2006 Jun 2.
2005
Huysmans, G., A. Ranquin, L. Wyns, J. Steyaert, and P. Van Gelder, "Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules.", J Control Release, vol. 102, issue 1, pp. 171-9, 2005 Jan 20.
Mignon, P., S. Loverix, J. Steyaert, and P. Geerlings, "Influence of the pi-pi interaction on the hydrogen bonding capacity of stacked DNA/RNA bases.", Nucleic Acids Res, vol. 33, issue 6, pp. 1779-89, 2005.
2003
Loverix, S., and J. Steyaert, "Ribonucleases: from prototypes to therapeutic targets?", Curr Med Chem, vol. 10, issue 9, pp. 779-85, 2003 May.
2002
Mignon, P., J. Steyaert, R. Loris, P. Geerlings, and S. Loverix, "A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study.", J Biol Chem, vol. 277, issue 39, pp. 36770-4, 2002 Sep 27.
2001
Deswarte, J., S. De Vos, U. Langhorst, J. Steyaert, and R. Loris, "The contribution of metal ions to the conformational stability of ribonuclease T1: crystal versus solution.", Eur J Biochem, vol. 268, issue 14, pp. 3993-4000, 2001 Jul.
De Vos, S., J. Backmann, M. Prévost, J. Steyaert, and R. Loris, "Hydrophobic core manipulations in ribonuclease T1.", Biochemistry, vol. 40, issue 34, pp. 10140-9, 2001 Aug 28.

Pages