Publications

Found 20 results
Filters: Keyword is Models, Molecular and Author is Wim Versées  [Clear All Filters]
2014
Somme, J., B. Van Laer, M. Roovers, J. Steyaert, W. Versées, and L. Droogmans, "Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates.", RNA, vol. 20, issue 8, pp. 1257-71, 2014 Aug.
2013
Vanderhaegen, S., M. Fislage, K. Domanska, W. Versées, E. Pardon, V. Bellotti, and J. Steyaert, "Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis.", Protein Sci, vol. 22, issue 10, pp. 1349-57, 2013 Oct.
2012
Fislage, M., M. Roovers, I. Tuszynska, J. M. Bujnicki, L. Droogmans, and W. Versées, "Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life.", Nucleic Acids Res, vol. 40, issue 11, pp. 5149-61, 2012 Jun.
2009
Versées, W., A. Goeminne, M. Berg, A. Vandemeulebroucke, A. Haemers, K. Augustyns, and J. Steyaert, "Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.", Biochim Biophys Acta, vol. 1794, issue 6, pp. 953-60, 2009 Jun.
Meyer, S., A. Wittinghofer, and W. Versées, "G-domain dimerization orchestrates the tRNA wobble modification reaction in the MnmE/GidA complex.", J Mol Biol, vol. 392, issue 4, pp. 910-22, 2009 Oct 2.
Berg, M., G. Bal, A. Goeminne, P. Van der Veken, W. Versées, J. Steyaert, A. Haemers, and K. Augustyns, "Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors.", ChemMedChem, vol. 4, issue 2, pp. 249-60, 2009 Feb.
2008
Meyer, S., A. Scrima, W. Versées, and A. Wittinghofer, "Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate.", J Mol Biol, vol. 380, issue 3, pp. 532-47, 2008 Jul 11.
Vandemeulebroucke, A., S. De Vos, E. Van Holsbeke, J. Steyaert, and W. Versées, "A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax.", J Biol Chem, vol. 283, issue 32, pp. 22272-82, 2008 Aug 8.
Goeminne, A., M. Berg, M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, et al., "N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase.", Bioorg Med Chem, vol. 16, issue 14, pp. 6752-63, 2008 Jul 15.
Goeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, and K. Augustyns, "Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.", Eur J Med Chem, vol. 43, issue 2, pp. 315-26, 2008 Feb.
2007
Versées, W., S. Spaepen, J. Vanderleyden, and J. Steyaert, "The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanism.", FEBS J, vol. 274, issue 9, pp. 2363-75, 2007 May.
Cordeiro, A. T., A. J. Cáceres, D. Vertommen, J. Luis Concepción, P. A. M. Michels, and W. Versées, "The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes.", J Mol Biol, vol. 372, issue 5, pp. 1215-26, 2007 Oct 5.
Versées, W., S. Spaepen, M. D. H. Wood, F. J. Leeper, J. Vanderleyden, and J. Steyaert, "Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.", J Biol Chem, vol. 282, issue 48, pp. 35269-78, 2007 Nov 30.
2006
Muzzolini, L., W. Versées, P. Tornaghi, E. Van Holsbeke, J. Steyaert, and M. Degano, "New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product.", Biochemistry, vol. 45, issue 3, pp. 773-82, 2006 Jan 24.
Buts, L., A. Garcia-Pino, A. Imberty, N. Amiot, G-J. Boons, S. Beeckmans, W. Versées, L. Wyns, and R. Loris, "Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin.", FEBS J, vol. 273, issue 11, pp. 2407-20, 2006 Jun.
Versées, W., J. Barlow, and J. Steyaert, "Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.", J Mol Biol, vol. 359, issue 2, pp. 331-46, 2006 Jun 2.
2005
Loverix, S., P. Geerlings, M. McNaughton, K. Augustyns, A. Vandemeulebroucke, J. Steyaert, and W. Versées, "Substrate-assisted leaving group activation in enzyme-catalyzed N-glycosidic bond cleavage.", J Biol Chem, vol. 280, issue 15, pp. 14799-802, 2005 Apr 15.
2004
Versées, W., S. Loverix, A. Vandemeulebroucke, P. Geerlings, and J. Steyaert, "Leaving group activation by aromatic stacking: an alternative to general acid catalysis.", J Mol Biol, vol. 338, issue 1, pp. 1-6, 2004 Apr 16.
2002
Versées, W., K. Decanniere, E. Van Holsbeke, N. Devroede, and J. Steyaert, "Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.", J Biol Chem, vol. 277, issue 18, pp. 15938-46, 2002 May 3.
2001
Versées, W., K. Decanniere, R. Pellé, J. Depoorter, E. Brosens, D. W. Parkin, and J. Steyaert, "Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.", J Mol Biol, vol. 307, issue 5, pp. 1363-79, 2001 Apr 13.