Publications
Found 24 results
Filters: Author is Dirk Saerens [Clear All Filters]
"Dual beneficial effect of interloop disulfide bond for single domain antibody fragments.",
J Biol Chem, vol. 287, issue 3, pp. 1970-9, 2012 Jan 13.
"Nanobody-based chromatin immunoprecipitation.",
Methods Mol Biol, vol. 911, pp. 491-505, 2012.
"Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII scorpion toxin.",
Protein Eng Des Sel, vol. 24, issue 9, pp. 727-35, 2011 Sep.
"Generation of anti-infectome/anti-proteome nanobodies.",
Methods Mol Biol, vol. 790, pp. 239-59, 2011.
"High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.",
PLoS Pathog, vol. 7, issue 6, pp. e1002072, 2011 Jun.
"A simple quantitative affinity capturing assay of poliovirus antigens and subviral particles by single-domain antibodies using magnetic beads.",
J Virol Methods, vol. 173, issue 2, pp. 300-5, 2011 May.
"A bispecific nanobody to provide full protection against lethal scorpion envenoming.",
FASEB J, vol. 24, issue 9, pp. 3479-89, 2010 Sep.
"Nanobodies®: proficient tools in diagnostics.",
Expert Rev Mol Diagn, vol. 10, issue 6, pp. 777-85, 2010 Sep.
"Camelid immunoglobulins and nanobody technology.",
Vet Immunol Immunopathol, vol. 128, issue 1-3, pp. 178-83, 2009 Mar 15.
"General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold.",
J Biol Chem, vol. 284, issue 5, pp. 3273-84, 2009 Jan 30.
"Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom.",
Biochem J, vol. 424, issue 2, pp. 263-72, 2009 Dec 1.
"Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis.",
Int J Parasitol, vol. 39, issue 5, pp. 625-33, 2009 Apr.
"Antibody technology in proteomics.",
Brief Funct Genomic Proteomic, vol. 7, issue 4, pp. 275-82, 2008 Jul.
"Disulfide bond introduction for general stabilization of immunoglobulin heavy-chain variable domains.",
J Mol Biol, vol. 377, issue 2, pp. 478-88, 2008 Mar 21.
"Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.",
Biochemistry, vol. 47, issue 42, pp. 11041-54, 2008 Oct 21.
"Parallel selection of multiple anti-infectome Nanobodies without access to purified antigens.",
J Immunol Methods, vol. 329, issue 1-2, pp. 138-50, 2008 Jan 1.
"Single-domain antibodies as building blocks for novel therapeutics.",
Curr Opin Pharmacol, vol. 8, issue 5, pp. 600-8, 2008 Oct.
"VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'.",
Mol Immunol, vol. 45, issue 14, pp. 3847-56, 2008 Aug.
"Antibody repertoire development in camelids.",
Dev Comp Immunol, vol. 30, issue 1-2, pp. 187-98, 2006.
"Engineering camel single-domain antibodies and immobilization chemistry for human prostate-specific antigen sensing.",
Anal Chem, vol. 77, issue 23, pp. 7547-55, 2005 Dec 1.
"Identification of a universal VHH framework to graft non-canonical antigen-binding loops of camel single-domain antibodies.",
J Mol Biol, vol. 352, issue 3, pp. 597-607, 2005 Sep 23.
"Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays.",
Biosens Bioelectron, vol. 21, issue 3, pp. 483-90, 2005 Sep 15.
"Single domain antibodies derived from dromedary lymph node and peripheral blood lymphocytes sensing conformational variants of prostate-specific antigen.",
J Biol Chem, vol. 279, issue 50, pp. 51965-72, 2004 Dec 10.
"An S-layer heavy chain camel antibody fusion protein for generation of a nanopatterned sensing layer to detect the prostate-specific antigen by surface plasmon resonance technology.",
Bioconjug Chem, vol. 15, issue 3, pp. 664-71, 2004 May-Jun.