Publications

Found 155 results
Filters: Author is Jan Steyaert  [Clear All Filters]
2008
Vandemeulebroucke, A., S. De Vos, E. Van Holsbeke, J. Steyaert, and W. Versées, "A flexible loop as a functional element in the catalytic mechanism of nucleoside hydrolase from Trypanosoma vivax.", J Biol Chem, vol. 283, issue 32, pp. 22272-82, 2008 Aug 8.
Goeminne, A., M. Berg, M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, et al., "N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase.", Bioorg Med Chem, vol. 16, issue 14, pp. 6752-63, 2008 Jul 15.
Goeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, A. Haemers, and K. Augustyns, "Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors.", Eur J Med Chem, vol. 43, issue 2, pp. 315-26, 2008 Feb.
2007
Goeminne, A., M. McNaughton, G. Bal, G. Surpateanu, P. Van der Veken, S. De Prol, W. Versées, J. Steyaert, S. Apers, A. Haemers, et al., "1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.", Bioorg Med Chem Lett, vol. 17, issue 9, pp. 2523-6, 2007 May 1.
Spaepen, S., W. Versées, D. Gocke, M. Pohl, J. Steyaert, and J. Vanderleyden, "Characterization of phenylpyruvate decarboxylase, involved in auxin production of Azospirillum brasilense.", J Bacteriol, vol. 189, issue 21, pp. 7626-33, 2007 Nov.
Versées, W., S. Spaepen, J. Vanderleyden, and J. Steyaert, "The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 A resolution. Implications for its catalytic and regulatory mechanism.", FEBS J, vol. 274, issue 9, pp. 2363-75, 2007 May.
Barlow, J. N., and J. Steyaert, "Examination of the mechanism and energetic contribution of leaving group activation in the purine-specific nucleoside hydrolase from Trypanosoma vivax.", Biochim Biophys Acta, vol. 1774, issue 11, pp. 1451-61, 2007 Nov.
Versées, W., S. Spaepen, M. D. H. Wood, F. J. Leeper, J. Vanderleyden, and J. Steyaert, "Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.", J Biol Chem, vol. 282, issue 48, pp. 35269-78, 2007 Nov 30.
2006
Vandemeulebroucke, A., W. Versées, J. Steyaert, and J. N. Barlow, "Multiple transients in the pre-steady-state of nucleoside hydrolase reveal complex substrate binding, product base release, and two apparent rates of chemistry.", Biochemistry, vol. 45, issue 30, pp. 9307-18, 2006 Aug 1.
Muzzolini, L., W. Versées, P. Tornaghi, E. Van Holsbeke, J. Steyaert, and M. Degano, "New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product.", Biochemistry, vol. 45, issue 3, pp. 773-82, 2006 Jan 24.
Versées, W., J. Barlow, and J. Steyaert, "Transition-state complex of the purine-specific nucleoside hydrolase of T. vivax: enzyme conformational changes and implications for catalysis.", J Mol Biol, vol. 359, issue 2, pp. 331-46, 2006 Jun 2.
2005
Huysmans, G., A. Ranquin, L. Wyns, J. Steyaert, and P. Van Gelder, "Encapsulation of therapeutic nucleoside hydrolase in functionalised nanocapsules.", J Control Release, vol. 102, issue 1, pp. 171-9, 2005 Jan 20.
Mignon, P., S. Loverix, J. Steyaert, and P. Geerlings, "Influence of the pi-pi interaction on the hydrogen bonding capacity of stacked DNA/RNA bases.", Nucleic Acids Res, vol. 33, issue 6, pp. 1779-89, 2005.
Loverix, S., P. Geerlings, M. McNaughton, K. Augustyns, A. Vandemeulebroucke, J. Steyaert, and W. Versées, "Substrate-assisted leaving group activation in enzyme-catalyzed N-glycosidic bond cleavage.", J Biol Chem, vol. 280, issue 15, pp. 14799-802, 2005 Apr 15.
Ranquin, A., W. Versées, W. Meier, J. Steyaert, and P. Van Gelder, "Therapeutic nanoreactors: combining chemistry and biology in a novel triblock copolymer drug delivery system.", Nano Lett, vol. 5, issue 11, pp. 2220-4, 2005 Nov.
2004
Versées, W., S. Loverix, A. Vandemeulebroucke, P. Geerlings, and J. Steyaert, "Leaving group activation by aromatic stacking: an alternative to general acid catalysis.", J Mol Biol, vol. 338, issue 1, pp. 1-6, 2004 Apr 16.
2003
Versées, W., and J. Steyaert, "Catalysis by nucleoside hydrolases.", Curr Opin Struct Biol, vol. 13, issue 6, pp. 731-8, 2003 Dec.
Versées, W., E. Van Holsbeke, S. De Vos, K. Decanniere, I. Zegers, and J. Steyaert, "Cloning, preliminary characterization and crystallization of nucleoside hydrolases from Caenorhabditis elegans and Campylobacter jejuni.", Acta Crystallogr D Biol Crystallogr, vol. 59, issue Pt 6, pp. 1087-9, 2003 Jun.
Vandemeulebroucke, A., W. Versées, S. De Vos, E. Van Holsbeke, and J. Steyaert, "Pre-steady-state analysis of the nucleoside hydrolase of Trypanosoma vivax. Evidence for half-of-the-sites reactivity and rate-limiting product release.", Biochemistry, vol. 42, issue 44, pp. 12902-8, 2003 Nov 11.
Loverix, S., and J. Steyaert, "Ribonucleases: from prototypes to therapeutic targets?", Curr Med Chem, vol. 10, issue 9, pp. 779-85, 2003 May.
2002
Versées, W., K. Decanniere, E. Van Holsbeke, N. Devroede, and J. Steyaert, "Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax.", J Biol Chem, vol. 277, issue 18, pp. 15938-46, 2002 May 3.
Mignon, P., J. Steyaert, R. Loris, P. Geerlings, and S. Loverix, "A nucleophile activation dyad in ribonucleases. A combined X-ray crystallographic/ab initio quantum chemical study.", J Biol Chem, vol. 277, issue 39, pp. 36770-4, 2002 Sep 27.
2001
Deswarte, J., S. De Vos, U. Langhorst, J. Steyaert, and R. Loris, "The contribution of metal ions to the conformational stability of ribonuclease T1: crystal versus solution.", Eur J Biochem, vol. 268, issue 14, pp. 3993-4000, 2001 Jul.
De Vos, S., J. Backmann, M. Prévost, J. Steyaert, and R. Loris, "Hydrophobic core manipulations in ribonuclease T1.", Biochemistry, vol. 40, issue 34, pp. 10140-9, 2001 Aug 28.
Versées, W., K. Decanniere, R. Pellé, J. Depoorter, E. Brosens, D. W. Parkin, and J. Steyaert, "Structure and function of a novel purine specific nucleoside hydrolase from Trypanosoma vivax.", J Mol Biol, vol. 307, issue 5, pp. 1363-79, 2001 Apr 13.

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