A million peptide motifs for the molecular biologist.

TitleA million peptide motifs for the molecular biologist.
Publication TypeJournal Article
Year of Publication2014
AuthorsTompa, P., N. E. Davey, T. J. Gibson, and M. M Babu
JournalMol Cell
Date Published2014 Jul 17
KeywordsAmino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Humans, Molecular Biology, Molecular Sequence Data, Protein Binding, Protein Interaction Domains and Motifs, Protein Processing, Post-Translational, Proteins

A molecular description of functional modules in the cell is the focus of many high-throughput studies in the postgenomic era. A large portion of biomolecular interactions in virtually all cellular processes is mediated by compact interaction modules, referred to as peptide motifs. Such motifs are typically less than ten residues in length, occur within intrinsically disordered regions, and are recognized and/or posttranslationally modified by structured domains of the interacting partner. In this review, we suggest that there might be over a million instances of peptide motifs in the human proteome. While this staggering number suggests that peptide motifs are numerous and the most understudied functional module in the cell, it also holds great opportunities for new discoveries.

Alternate JournalMol. Cell
PubMed ID25038412
Grant ListMC_U105185859 / / Medical Research Council / United Kingdom
Research group: