Antibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor.

TitleAntibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor.
Publication TypeJournal Article
Year of Publication2014
AuthorsLa Greca, F., C. Haynes, B. Stijlemans, C. De Trez, and S. Magez
JournalParasite Immunol
Volume36
Issue6
Pagination271-6
Date Published2014 Jun
ISSN1365-3024
KeywordsAnimals, Antibodies, Female, Mice, Mice, Inbred AKR, Mice, Inbred C57BL, Parasitemia, Trypanosoma vivax, Trypanosomiasis, African, Tumor Necrosis Factor-alpha
Abstract

Trypanosoma vivax causes a wasting disease affecting livestock breeding and agriculture in developing countries of sub-Sahara Africa and South America. Being an extracellular parasite, control of T. vivax has been proposed to be mediated by host antibodies. However, the use of a comparative infection model of wild-type (WT) and tumour necrosis factor (TNF) knockout (TNF(-/-) ) mice shows that the latter is unable to control first-peak parasitaemia, despite the presence of specific antitrypanosome antibodies. In contrast, WT mice parasitaemia peak control coincides with a combined early onset of TNF production and induction of specific antibodies. TNF is mainly produced by liver-associated monocytes and neutrophils. In this study, no other correlation between cellular immunomodulations and peak parasitaemia control was observed, underscoring the importance of the role of TNF in the control of T. vivax infections.

DOI10.1111/pim.12106
Alternate JournalParasite Immunol.
PubMed ID24697754
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