Nanobody-based products as research and diagnostic tools.

TitleNanobody-based products as research and diagnostic tools.
Publication TypeJournal Article
Year of Publication2014
AuthorsDe Meyer, T., S. Muyldermans, and A. Depicker
JournalTrends Biotechnol
Volume32
Issue5
Pagination263-70
Date Published2014 May
ISSN1879-3096
KeywordsBiological Products, Biomedical Research, Humans, Single-Domain Antibodies
Abstract

Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies, have received a progressively growing interest. As a result of the beneficial properties of these stable recombinant entities, they are currently highly valued proteins for multiple applications, including fundamental research, diagnostics, and therapeutics. Today, with the original patents expiring, even more academic and industrial groups are expected to explore innovative VHH applications. Here, we provide a thorough overview of novel implementations of VHHs as research and diagnostic tools, and of the recently evaluated production platforms for several VHHs and VHH-derived antibody formats.

DOI10.1016/j.tibtech.2014.03.001
Alternate JournalTrends Biotechnol.
PubMed ID24698358
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