Bacterial surface appendages as targets for novel antibacterial therapeutics.

TitleBacterial surface appendages as targets for novel antibacterial therapeutics.
Publication TypeJournal Article
Year of Publication2014
AuthorsSteadman, D., A. Lo, G. Waksman, and H. Remaut
JournalFuture Microbiol
Volume9
Issue7
Pagination887-900
Date Published2014
ISSN1746-0921
KeywordsAnimals, Anti-Bacterial Agents, Cell Surface Extensions, Gram-Negative Bacteria, Gram-Negative Bacterial Infections, Humans, Virulence
Abstract

The rise of multidrug resistant bacteria is a major worldwide health concern. There is currently an unmet need for the development of new and selective antibacterial drugs. Therapies that target and disarm the crucial virulence factors of pathogenic bacteria, while not actually killing the cells themselves, could prove to be vital for the treatment of numerous diseases. This article discusses the main surface architectures of pathogenic Gram-negative bacteria and the small molecules that have been discovered, which target their specific biogenesis pathways and/or actively block their virulence. The future perspective for the use of antivirulence compounds is also assessed.

DOI10.2217/fmb.14.46
Alternate JournalFuture Microbiol
PubMed ID25156378
Grant List018434 / / Medical Research Council / United Kingdom
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