Coding Regions of Intrinsic Disorder Accommodate Parallel Functions.

TitleCoding Regions of Intrinsic Disorder Accommodate Parallel Functions.
Publication TypeJournal Article
Year of Publication2016
AuthorsPancsa, R., and Tompa P.
JournalTrends Biochem Sci
Volume41
Issue11
Pagination898-906
Date Published2016 Nov
ISSN0968-0004
KeywordsEvolution, Molecular, Exons, Gene Expression, HIV-1, Humans, Intrinsically Disordered Proteins, Models, Molecular, Open Reading Frames, Plasmodium falciparum, Protein Conformation, Protein Folding, RNA, Messenger, Selection, Genetic, Structure-Activity Relationship
Abstract

Numerous DNA- and RNA-level functions are embedded in protein-coding regions, which constrains their structure, function, and evolution. Accumulating evidence suggests that such additional, overlapping functions occur preferentially in the coding sequences of intrinsically disordered proteins/regions (IDPs/IDRs), especially in those that are newly incorporated and thus have reduced selective pressure. It is the lack of strict structural constraints that makes disordered proteins more tolerant to mutations and thus more permissive to the appearance of overlapping functions within their coding sequences than structured domains. Therefore, IDPs/IDRs are often mosaics of segments fulfilling protein functionalities and intervening regions primarily carrying nucleotide-level functions. The ensuing complexification of gene-regulatory circuits may have contributed to the evolutionary spread of structural disorder in complex eukaryotic organisms.

DOI10.1016/j.tibs.2016.08.009
Alternate JournalTrends Biochem. Sci.
PubMed ID27647212
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