Towards Understanding Protein Disorder In-Cell.

TitleTowards Understanding Protein Disorder In-Cell.
Publication TypeJournal Article
Year of Publication2015
AuthorsCedeño, C., Raveh-Hamit H., Dinnyés A., and Tompa P.
JournalAdv Exp Med Biol
Volume870
Pagination319-34
Date Published2015
ISSN0065-2598
KeywordsEscherichia coli, Intrinsically Disordered Proteins, Nuclear Magnetic Resonance, Biomolecular, Protein Conformation
Abstract

Investigating the activity and structure of cellular biochemical machinery at atomic resolution has been a point of paramount significance for understanding health and disease over the decades. The underlying molecular mechanisms are primarily studied in vitro. Nuclear magnetic resonance (NMR) is a technique that allows to look into cells and study proteins and other constituents, thanks to careful experimental design and technological advances (spectrometer sensitivity and pulse sequence design). Here we outline current applications of the technique and propose a realistic future for the field.

DOI10.1007/978-3-319-20164-1_10
Alternate JournalAdv. Exp. Med. Biol.
PubMed ID26387107
Research group: