|Title||Towards Understanding Protein Disorder In-Cell.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Cedeño, C., H. Raveh-Hamit, A. Dinnyés, and P. Tompa|
|Journal||Adv Exp Med Biol|
|Keywords||Escherichia coli, Intrinsically Disordered Proteins, Nuclear Magnetic Resonance, Biomolecular, Protein Conformation|
Investigating the activity and structure of cellular biochemical machinery at atomic resolution has been a point of paramount significance for understanding health and disease over the decades. The underlying molecular mechanisms are primarily studied in vitro. Nuclear magnetic resonance (NMR) is a technique that allows to look into cells and study proteins and other constituents, thanks to careful experimental design and technological advances (spectrometer sensitivity and pulse sequence design). Here we outline current applications of the technique and propose a realistic future for the field.
|Alternate Journal||Adv. Exp. Med. Biol.|
Towards Understanding Protein Disorder In-Cell.