Towards Understanding Protein Disorder In-Cell.

TitleTowards Understanding Protein Disorder In-Cell.
Publication TypeJournal Article
Year of Publication2015
AuthorsCedeño, C., H. Raveh-Hamit, A. Dinnyés, and P. Tompa
JournalAdv Exp Med Biol
Date Published2015
KeywordsEscherichia coli, Intrinsically Disordered Proteins, Nuclear Magnetic Resonance, Biomolecular, Protein Conformation

Investigating the activity and structure of cellular biochemical machinery at atomic resolution has been a point of paramount significance for understanding health and disease over the decades. The underlying molecular mechanisms are primarily studied in vitro. Nuclear magnetic resonance (NMR) is a technique that allows to look into cells and study proteins and other constituents, thanks to careful experimental design and technological advances (spectrometer sensitivity and pulse sequence design). Here we outline current applications of the technique and propose a realistic future for the field.

Alternate JournalAdv. Exp. Med. Biol.
PubMed ID26387107
Research group: