The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting.

TitleThe role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting.
Publication TypeJournal Article
Year of Publication2015
AuthorsTantos, Á., Kalmar L., and Tompa P.
JournalExpert Rev Proteomics
Volume12
Issue3
Pagination221-33
Date Published2015 Jun
ISSN1744-8387
KeywordsAnimals, Cell Cycle Checkpoints, Cellular Structures, Clinical Medicine, Disease, Drug Delivery Systems, Humans, Proteomics, Signal Transduction
Abstract

Understanding the molecular mechanisms of the regulation of cell cycle is a central issue in molecular cell biology, due to its fundamental role in the existence of cells. The regulatory circuits that make decisions on when a cell should divide are very complex and particularly subtly balanced in eukaryotes, in which the harmony of many different cells in an organism is essential for life. Several hundred proteins are involved in these processes, and a great deal of studies attests that most of them have functionally relevant intrinsic structural disorder. Structural disorder imparts many functional advantages on these proteins, and we discuss it in detail that it is involved in all key steps from signaling through the cell membrane to regulating transcription of proteins that execute timely responses to an ever-changing environment.

DOI10.1586/14789450.2015.1042866
Alternate JournalExpert Rev Proteomics
PubMed ID25976105
Research group: