Could ecosystem management provide a new framework for Alzheimer's disease?

TitleCould ecosystem management provide a new framework for Alzheimer's disease?
Publication TypeJournal Article
Year of Publication2016
AuthorsHubin, E., B. Vanschoenwinkel, K. Broersen, P. P. De Deyn, N. Koedam, N. A. Van Nuland, and K. Pauwels
JournalAlzheimers Dement
Volume12
Issue1
Pagination65-74.e1
Date Published2016 Jan
ISSN1552-5279
KeywordsAlzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Brain, Ecosystem, Humans
Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative brain disorder that involves a plethora of molecular pathways. In the context of therapeutic treatment and biomarker profiling, the amyloid-beta (Aβ) peptide constitutes an interesting research avenue that involves interactions within a complex mixture of Aβ alloforms and other disease-modifying factors. Here, we explore the potential of an ecosystem paradigm as a novel way to consider AD and Aβ dynamics in particular. We discuss the example that the complexity of the Aβ network not only exhibits interesting parallels with the functioning of complex systems such as ecosystems but that this analogy can also provide novel insights into the neurobiological phenomena in AD and serve as a communication tool. We propose that combining network medicine with general ecosystem management principles could be a new and holistic approach to understand AD pathology and design novel therapies.

DOI10.1016/j.jalz.2015.07.491
Alternate JournalAlzheimers Dement
PubMed ID26341147
Research group: