Thiol Redox and pKa Properties of Mycothiol, the Predominant Low-Molecular-Weight Thiol Cofactor in the Actinomycetes.

TitleThiol Redox and pKa Properties of Mycothiol, the Predominant Low-Molecular-Weight Thiol Cofactor in the Actinomycetes.
Publication TypeJournal Article
Year of Publication2016
AuthorsSharma, S. V., K. Van Laer, J. Messens, and C. J. Hamilton
JournalChembiochem
Volume17
Issue18
Pagination1689-92
Date Published2016 09 15
ISSN1439-7633
KeywordsActinobacteria, Coenzymes, Cysteine, Glycopeptides, Hydrogen-Ion Concentration, Inositol, Molecular Conformation, Molecular Weight, Oxidation-Reduction, Sulfhydryl Compounds
Abstract

The thiol pKa and standard redox potential of mycothiol, the major low-molecular-weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.
DOI10.1002/cbic.201600228
Alternate JournalChembiochem
PubMed ID27332744
subject_category: 
Redox
Research group: 
MessensGroup