The Landscape of Intertwined Associations in Homooligomeric Proteins.

TitleThe Landscape of Intertwined Associations in Homooligomeric Proteins.
Publication TypeJournal Article
Year of Publication2015
AuthorsWodak, S. J., A. Malevanets, and S. S. Mackinnon
JournalBiophys J
Date Published2015 Sep 15
KeywordsProtein Multimerization, Protein Stability, Protein Subunits

We present an overview of the full repertoire of intertwined associations in homooligomeric proteins. This overview summarizes recent findings on the different categories of intertwined associations in known protein structures, their assembly modes, the properties of their interfaces, and their structural plasticity. Furthermore, the current body of knowledge on the so-called three-dimensional domain-swapped systems is reexamined in the context of the wider landscape of intertwined homooligomers, with a particular focus on the mechanistic aspects that underpin intertwined self-association processes in proteins. Insights gained from this integrated overview into the physical and biological roles of intertwining are highlighted.

Alternate JournalBiophys. J.
PubMed ID26340815
PubMed Central IDPMC4576362
Grant List / / Canadian Institutes of Health Research / Canada
Research group: