|Title||Protein Phase Separation: A New Phase in Cell Biology.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Boeynaems, S., S. Alberti, N. L. Fawzi, T. Mittag, M. Polymenidou, F. Rousseau, J. Schymkowitz, J. Shorter, B. Wolozin, L. Van Den Bosch, P. Tompa, and M. Fuxreiter|
|Journal||Trends Cell Biol|
|Date Published||2018 Jun|
Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein phase separation. Recent discoveries have shed light on the molecular properties, formation, regulation, and function of membraneless organelles. A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.
|Alternate Journal||Trends Cell Biol.|
|PubMed Central ID||PMC6034118|
|Grant List||R01 AG050471 / AG / NIA NIH HHS / United States |
R01 GM099836 / GM / NIGMS NIH HHS / United States
Protein Phase Separation: A New Phase in Cell Biology.