Protein Phase Separation: A New Phase in Cell Biology.

TitleProtein Phase Separation: A New Phase in Cell Biology.
Publication TypeJournal Article
Year of Publication2018
AuthorsBoeynaems, S., S. Alberti, N. L. Fawzi, T. Mittag, M. Polymenidou, F. Rousseau, J. Schymkowitz, J. Shorter, B. Wolozin, L. Van Den Bosch, P. Tompa, and M. Fuxreiter
JournalTrends Cell Biol
Volume28
Issue6
Pagination420-435
Date Published2018 Jun
ISSN1879-3088
Abstract

Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu. There are also many so-called membraneless organelles and recent studies suggest that these organelles, which are supramolecular assemblies of proteins and RNA molecules, form via protein phase separation. Recent discoveries have shed light on the molecular properties, formation, regulation, and function of membraneless organelles. A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.

DOI10.1016/j.tcb.2018.02.004
Alternate JournalTrends Cell Biol.
PubMed ID29602697
PubMed Central IDPMC6034118
Grant ListR01 AG050471 / AG / NIA NIH HHS / United States
R01 GM099836 / GM / NIGMS NIH HHS / United States
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