Title | Future perspective for potential Helicobacter pylori eradication therapies. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Debraekeleer, A., and H. Remaut |
Journal | Future Microbiol |
Volume | 13 |
Pagination | 671-687 |
Date Published | 2018 05 |
ISSN | 1746-0921 |
Abstract | Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a major risk factor for the development of peptic ulcer disease and gastric cancer. Current standard eradication therapies use an acid-suppressing drug and two antibiotics, now frequently supplemented with bismuth. Declining eradication efficiencies, off-target effects of lengthy broad-spectrum antibiotic treatments and the desire of a more systematic eradication in asymptomatic H. pylori carriers to suppress gastric cancer incidence spur a search for an effective vaccine and alternative therapeutic options. Here, we review the current progress in the field, with an emphasis on narrow-spectrum or nonantibiotic therapeutics. |
DOI | 10.2217/fmb-2017-0115 |
Alternate Journal | Future Microbiol |
PubMed ID | 29798689 |
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