Future perspective for potential Helicobacter pylori eradication therapies.

TitleFuture perspective for potential Helicobacter pylori eradication therapies.
Publication TypeJournal Article
Year of Publication2018
AuthorsDebraekeleer, A., and H. Remaut
JournalFuture Microbiol
Volume13
Pagination671-687
Date Published2018 05
ISSN1746-0921
Abstract

Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a major risk factor for the development of peptic ulcer disease and gastric cancer. Current standard eradication therapies use an acid-suppressing drug and two antibiotics, now frequently supplemented with bismuth. Declining eradication efficiencies, off-target effects of lengthy broad-spectrum antibiotic treatments and the desire of a more systematic eradication in asymptomatic H. pylori carriers to suppress gastric cancer incidence spur a search for an effective vaccine and alternative therapeutic options. Here, we review the current progress in the field, with an emphasis on narrow-spectrum or nonantibiotic therapeutics.

DOI10.2217/fmb-2017-0115
Alternate JournalFuture Microbiol
PubMed ID29798689
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