An intrinsically disordered proteins community for ELIXIR.

TitleAn intrinsically disordered proteins community for ELIXIR.
Publication TypeJournal Article
Year of Publication2019
AuthorsDavey, N. E., M. M Babu, M. Blackledge, A. Bridge, S. Capella-Gutierrez, Z. Dosztányi, R. Drysdale, R. J. Edwards, A. Elofsson, I. C. Felli, T. J. Gibson, A. Gutmanas, J. M. Hancock, J. Harrow, D. Higgins, C. M. Jeffries, P. Le Mercier, B. Mészáros, M. Necci, C. Notredame, S. Orchard, C. A. Ouzounis, R. Pancsa, E. Papaleo, R. Pierattelli, D. Piovesan, V. J. Promponas, P. Ruch, G. Rustici, P. Romero, S. Sarntivijai, G. Saunders, B. Schuler, M. Sharan, D. C. Shields, J. L. Sussman, J. A. Tedds, P. Tompa, M. Turewicz, J. Vondrasek, W. F. Vranken, B. Ann Wallace, K. Wichapong, and S. C. E. Tosatto
Date Published2019

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled "An intrinsically disordered protein user community proposal for ELIXIR" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.

Alternate JournalF1000Res
PubMed ID31824649
PubMed Central IDPMC6880265
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