Protein sulfenic acid formation: from cellular damage to redox regulation.

TitleProtein sulfenic acid formation: from cellular damage to redox regulation.
Publication TypeJournal Article
Year of Publication2011
AuthorsRoos, G., and J. Messens
JournalFree Radic Biol Med
Volume51
Issue2
Pagination314-26
Date Published2011 Jul 15
Type of Articleredox
ISSN1873-4596
KeywordsMolecular Probes, Oxidation-Reduction, Proteins, Sulfenic Acids
Abstract

Protein sulfenic acid formation has long been regarded as unwanted damage caused by reactive oxygen species (ROS). However, over the past 10 years, accumulating evidence has shown that the reversible oxidation of cysteine thiol groups to sulfenic acid functions as a redox-based signal transduction mechanism. Here, we review the mechanisms of sulfenic acid formation by ROS. We present some of the most important roles played by sulfenic acids in living cells as well as the pathways that regulate sulfenic acid formation. We highlight the experimental tools that have been developed to study the cellular sulfenome and show how computational approaches might help to better understand the mechanisms of sulfenic acid formation.

DOI10.1016/j.freeradbiomed.2011.04.031
Alternate JournalFree Radic. Biol. Med.
PubMed ID21605662
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