|Title||Novel therapy based on camelid nanobodies.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Unciti-Broceta, J. Diego, T. Del Castillo, M. Soriano, S. Magez, and J. A. Garcia-Salcedo|
|Date Published||2013 Oct|
|Type of Article||nanobody|
|Keywords||Animals, Antibody Specificity, Camelids, New World, Camels, Chemistry, Pharmaceutical, Drug Carriers, Humans, Immunotherapy, Immunotoxins, Nanomedicine, Protein Conformation, Single-Domain Antibodies, Structure-Activity Relationship|
Nanobodies (Nbs) are small antibody fragments derived from camelid heavy chain antibodies through recombinant gene technology. Their exceptional physicochemical properties, possibility of humanization and unique antigen recognition properties make them excellent candidates for targeted delivery of biologically active components. Several different therapeutic approaches based on the novel camelid Nbs have been developed to treat a wide range of diseases ranging from immune, bone, blood and neurological disorders; infectious diseases and cancer. This review provides a comprehensive overview of the current state of the use of camelid-derived Nbs as novel therapeutic agents against multiple diseases.
|Alternate Journal||Ther Deliv|
Novel therapy based on camelid nanobodies.