Vaccination against trypanosomiasis: can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?

TitleVaccination against trypanosomiasis: can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?
Publication TypeJournal Article
Year of Publication2011
AuthorsLa Greca, F., and S. Magez
JournalHum Vaccin
Volume7
Issue11
Pagination1225-33
Date Published2011 Nov
Type of Articleparasites
ISSN1554-8619
KeywordsAnimals, Antigenic Variation, Disease Models, Animal, Humans, Immunity, Innate, Mice, Protozoan Vaccines, Trypanosoma, Trypanosomiasis, African, Vaccination
Abstract

To date, human African trypanosomiasis (HAT) still threatens millions of people throughout sub-Sahara Africa, and new approaches to disease prevention and treatment remain a priority. It is commonly accepted that HAT is fatal unless treatment is provided. However, despite the well-described general symptoms of disease progression during distinct stages of the infection, leading to encephalitic complications, coma and death, a substantial body of evidence has been reported suggesting that natural acquired immunity could occur. Hence, if under favorable conditions natural infections can lead to correct immune activation and immune protection against HAT, the development of an effective anti-HAT vaccine should remain a central goal in the fight against this disease. In this review, we will (1) discuss the vaccine candidates that have been proposed over the past years, (2) highlight the main obstacles that an efficient anti-trypanosomiasis vaccine needs to overcome and (3) critically reflect on the validity of the widely used murine model for HAT.

DOI10.4161/hv.7.11.18203
Alternate JournalHum Vaccin
PubMed ID22205439
PubMed Central IDPMC3323498